neurology Research
Over the past several years, members of the Department of Neurology at the University of Toledo have conducted a number of funded research projects in the areas of epilepsy, stroke, multiple sclerosis and movement disorders. Projects have included the role of inflammatory cytokines and adhesion molecules in stroke and in migraine, novel therapeutic options in Parkinson Disease, Stroke, Multiple Sclerosis and Epilepsy.
The Research and Grants Administration has a multitude of resources available on line to assist in the preparation and submission of research proposals, as well as links to the major granting agencies.
clinical research
The University of Toledo Department of Neurology faculty have >300 scholarly peer-reviewed publications to answer specific clinical questions and/or disseminate clinical knowledge. Faculty members have also co-authored book chapters and serve as reviewers in high impact journals.
clinical trials
Members of the Department of Neurology at the University of Toledo have conducted a number of funded research projects in the areas of epilepsy, stroke, multiple sclerosis, and movement disorders.
Projects have included the role of inflammatory cytokines and adhesion molecules in stroke and in migraine, novel therapeutic options in Parkinson Disease, Stroke, Multiple Sclerosis and Epilepsy.
Current active clinical trials (and contact information) may be found at: https://www.utoledo.edu/med/research/jcctr/studies/Neurology.html
A number of these research projects involve collaboration between department members and colleagues in other UT clinical and basic science departments. Recent areas of interest for faculty members include neurological complications of Covid-19 infections, safety, and quality of care in the neurocritical care unit, epilepsy of late onset, tolerability of antiseizure medications, neurointervention in cerebrovascular disease, immunological treatment of multiple sclerosis and novel compounds for treatment of Huntington and Parkinson Disease.
stroke clinical trials (Toledo Hospital and ProMedica/University of Toledo neuroscience center)
TIMELESS - Tenecteplase for Acute Ischemic Stroke Outside tPA Window
CHARM - IV Glibenclamide for large hemispheric infarction
EMBOLISE - MMA Embolization with Onyx for subdural hematoma
SOFAST – Registry study for Sophia catheter as first line of treatment for acute ischemic stroke
MASTERS2 – Stem cell study for acute ischemic stroke [WILL OPEN TO ENROLLMENT SOON]
parkinson's disease and movement disorders trials
ACTIVATE BIA 28-6156-201– evaluation of the efficacy, safety, tolerability, pharmacodynamics, and pharmacokinetics in Parkinson’s patients with a pathogenic variant in the glucocerebrosidase (GBA1) gene
TEMPO 01 – evaluation of the tolerability, safety, and efficacy of Tavapadon in early Parkinson’s patients
TEMP0 03 - evaluation of the tolerability, safety, and efficacy of Tavapadon in Parkinson’s patients experiencing motor fluctuations
TEMPO 04 - 56 week open-label trial of Tavapadon in parkinson's patients
KINECT-HD – assess the efficacy, safety, and tolerability of valbenazine for chorea associated with Huntington’s disease
DIMENSION 718-CIH-201 – evaluation of the effects of Sage-718 on cognitive function in patients with Huntington's Disease
PRECEDENT 718-CNP-202 - evaluation of the effects of Sage-718 in Parkinson’s disease cognitive impairment
PURVIEW SAGE 781-CIH-301 – evaluation of the long-term safety and tolerability of Sage-718 in participants with Huntington's Disease
ATLANTIS PD0060 - evaluation the efficacy, safety, tolerability, and pharmacokinetics of UCB0022 in advanced Parkinson’s disease
educational research
A number of clinical faculty have an interest and expertise in educational research. In addition, to peer reviewed publications, a number of collaborative projects are ongoing locally with the Department of Medical Education as well with other institutions and organizations such as AAN.