Andrew Kleinhenz, B.S.
Department of Surgery
Integrated Core Facilities
Electron Microscopy Core
Email: andrew.kleinhenz@utoledo.edu
Office Phone: 419.383.5169
EDUCATION
B.S., Biology, Kent State University, Kent, Ohio 1996
Honors & Awards
Recipient of the 2021 University of Toledo College of Medicine and Life Sciences Dean’s Rising Star Staff Award.
Nominated and accepted into the 2019-2020 cohort of the University of Toledo’s Staff Leadership Development Program. A yearlong program designed to provide intensive and formalized training in career development for emerging leaders at the university of Toledo.
Outstanding Student Service Award, Kent State Undergraduate Student Senate 1991, 1992, 1993.
positions
May 2022-Present Microscopy Research Associate, University of Toledo, Department of Surgery, Integrated Core Facilities, Electron Microscopy Core (TEM), Toledo, Ohio.
2016-2022 Biomedical Research Associate, University of Toledo, Department of Medicine, Toledo, Ohio.
2003-2016 Business Owner, The Village Painter, Middlefield, Ohio.
2002-2003 Research Assistant III, Case Western Reserve University School of Medicine, Department of Neurosciences, Cleveland, Ohio.
2001-2002 Research Assistant III, Case Western Reserve University School of Medicine, Department of Human Genetics, Cleveland, Ohio.
1999-2001 Staff Scientist, ChantTest, Inc., Warrensville Heights, Ohio.
1999-1999 Research Assistant I, Marine Biological Laboratory, Ecosystems Center, Woods Hole, MA.
1997-1999 Research Assistant I, Rammelkamp Center, Metro Health Medical Center, Cleveland, Ohio.
1996-1997 Laboratory Technician/Aquatic Biologist, EnviroScience, Inc., Cuyahoga Falls, Ohio.
Publications
1. Su RC, Warner EA, Breidenbach JD, Lad A, Blomquist TM, Kleinhenz AL, Modyanov N, Malhotra D, Kennedy DJ, Haller ST. CD40 receptor knockout protects against microcystin-LR (MC-LR) prolongation and exacerbation of dextran sulfate sodium (DSS)-induced colitis. Biomedicines. 2020. 8(6), 149; https://doi.org/10.3390/biomedicines8060149.
2. Su RC, Lad A, Breidenbach J, Kleinhenz AL, Modyanov NN, Malhotra D, Haller ST, Kennedy DJ. Assessment of diagnostic biomarkers of liver injury in the setting of microcystin-LR (MC-LR) hepatotoxicity. Chemosphere. 2020; 265: 12711. https://doi.org/10.1016/j.chemosphere.2020.127111
3. Khalaf, FK, Dube P, Kleinhenz A, Malhotra D, Gohara A, Drummond CA, Tian J, Haller ST, Xie Z, Kennedy DJ. Pro-inflammatory Effects of the Cardiotonic Steroid Telocinobufagin Mediated by Na+/K+-ATPase α-1 /Src Complex in Renal Epithelial Cells and Immune Cells. Hypertension. 2019 Jul;74(1):73-82.doi: 10.1161/HYPERTENSIONAHA.118.12605. (PMC6561827)
4. Su R, Blomquist T, Kleinhenz A, Khalaf F, Dube P, Lad A, Breidenbach J, Mohammed C, Shang S, Baum C, Malhotra D, Kennedy DJ , Haller ST†. Exposure to the Harmful Algal Bloom (HAB) toxin microcystin-LR (MC-LR) prolongs and increases severity of dextran sulfate sodium (DSS)-induced colitis. Toxins.2019, 11(6), 371; https://doi.org/10.3390/toxins11060371 (PMC6628444)
5. Mohammed CJ, Ghosh S, Dube P, Levison BS, Xi Y, Brewster PS, Sarsour T, Kleinhenz A, Crawford EL, Malhotra D, James RW, Kalra PA, Haller ST, Kennedy DJ. Circulating Paraoxonase Activity but not Circulating Protein Predicts Adverse Outcomes in Subjects with Chronic Kidney Disease. J Clin Med.2019, 8(7), 1034; https://doi.org/10.3390/jcm8071034 (PMC6678354)
6. Lad A, Su R, Breidenbach J, Stemmer P, Carruthers N, Sanchez N, Khalaf FK, Zhang S, Kleinhenz A, Dube P, Mohammed CJ, Westrick J, Crawford E, Palagama D, Baliu-Rodriguez D, Isailovic D, Levison BS, Modyanov N, Gohara A, Malhotra D, Haller ST, Kennedy DJ. Chronic Low Dose Oral Exposure to Microcystin-LR Exacerbates Hepatic Injury in a Murine Model of Non-Alcoholic Fatty Liver Disease. Toxins. 2019, 11(9), 486; https://doi.org/10.3390/toxins11090486 (PMID 31450746)
7. Su RC, Lad A, Breidenbach JD, Blomquist TM, Gunning WT, Dube P, Andrew L. Kleinhenz, Malhotra D, Haller ST, Kennedy DJ. Hyperglycemia induces key genetic and phenotypic changes in human liver epithelial HepG2 cells which parallel the Leprdb/J mouse model of non-alcoholic fatty liver disease (NAFLD). PLoS ONE. 2019, 14(12): e0225604. https://doi.org/10.1371/journal.pone.0225604
8. Zhang S, Breidenbach JD, Khalaf FK, Dube PR, Mohammed CJ, Lad A, Stepkowski S, Hinds TD, Kumarasamy S, Kleinhenz A, Tian J, Malhotra D, Kennedy DJ, Cooper CJ, Haller ST. Renal fibrosis is significantly attenuated following targeted disruption of Cd40 in experimental renal ischemia. J Am Heart Assoc. 2020; 9(7):e014072. https://doi:10.1161/JAHA.119.014072 (PMID:32200719)
9. Lad, A.; Breidenbach, J.D.; Su, R.C.; Murray, J.; Kuang, R.; Mascarenhas, A.; Najjar, J.; Patel, S.; Hegde, P.; Youssef, M.; Breuler, J.; Kleinhenz, A.L.; Ault, A.P.; Westrick, J.A.; Modyanov, N.N.; Kennedy, D.J.; Haller, S.T. As We Drink and Breathe: Adverse Health Effects of Microcystins and Other Harmful Algal Bloom Toxins in the Liver, Gut, Lungs and Beyond. Life 2022, 12, 418. https://doi.org/10.3390/life12030418
10. Khalaf, F.K.; Mohammed, C.J.; Dube, P.; Connolly, J.A.; Lad, A.; Ashraf, U.M.; Breidenbach, J.D.; Su, R.C.; Kleinhenz, A.L.; Malhotra, D.; Gohara, A.F.; Haller, S.T.; Kennedy, D.J. Paraoxonase-1 Regulation of Renal Inflammation and Fibrosis in Chronic Kidney Disease. Antioxidants 2022, 11, 900. https://doi.org/10.3390/antiox11050900
11. Apurva Lad, Jonathan Hunyadi, Jacob Connolly, Joshua D. Breidenbach, Fatimah K. Khalaf1, Prabhatchandra Dube, Shungang Zhang, Andrew L. Kleinhenz, David Baliu-Rodriguez, Dragan Isailovic, Terry D. Hinds, Jr., Cara Gatto-Weis, Lauren M. Stanoszek, Thomas M. Blomquist, Deepak Malhotra, Steven T. Haller,* and David J. Kennedy,* Antioxidant Therapy Significantly Attenuates Hepatotoxicity following Low Dose Exposure to Microcystin-LR in a Murine Model of Diet-Induced Non-Alcoholic Fatty Liver Disease. Antioxidants 2022, 11(8), 1625; https://doi.org/10.3390/antiox11081625
12. Prabhatchandra Dube, Fatimah K. Khalaf, Armelle DeRiso, Chrysan J., Mohammed, Jacob A. Connolly, Dhanushya Battepati, Apurva Lad, Joshua D., Breidenbach, Andrew L. Kleinhenz, Bella Khatib-Shahidi, Mitra Patel, Iman, Tassavvor, Amira F. Gohara, Deepak Malhotra, Eric E. Morgan, Steven T. Haller, David J. Kennedy *. Cardioprotective Role for Paraoxonase-1 in Chronic Kidney Disease. Biomedicines 2022, 10, 2301. https://doi.org/10.3390/biomedicines10092301
13. Breidenbach JD, French BW, Gordon TT, Kleinhenz AL, Khalaf FK, Willey JC, Hammersley JR, Wooten RM, Crawford EL, Modyanov NN, Malhotra D, Teeguarden JG, Haller ST, Kennedy DJ. (2022) Microcystin-LR Aerosol Induces Inflammatory Responses in Healthy Human Primary Airway Epithelium. Environment International, 107531. https://doi.org/10.1016/j.envint.2022.107531