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University of Toledo Integrated Core Facilities (ICF)

Michael P. Morran, Ph.D.

Michael Morran, Ph.D. Research Assistant Professor
Department of Surgery, College of Medicine and Life Sciences
Office: 419.383.6028
Email: Michael.morran@utoledo.edu

EDUCATION

B.S., Biology, University of Toledo, Toledo, Ohio 2002
Ph.D., Medicinal Biological Chemistry, University of Toledo, Toledo, Ohio, 2006

POSTGRADUATE TRAINING

  • University of Michigan, Department of Internal Medicine, Ann Arbor, Michigan 2007-2012

ACADEMIC APPOINTMENTS

  • 2002-2005: Teaching Assistant, University of Toledo, Department of Medicinal Biological Chemistry, Toledo, Ohio 
  • 2002-2006: Research Assistant, University of Toledo, Department of Medicinal Biological Chemistry, Toledo, Ohio 
  • 2007- 2012: Research Fellow, University of Michigan, Department of Internal Medicine, Ann Arbor, Michigan 
  • 2012- 2014: Research Investigator, University of Michigan, Department of Internal Medicine, Ann Arbor, Michigan 
  • 2014- 2017: Research Assistant Professor, University of Toledo, Department of Medicinal Biological Chemistry, Toledo, Ohio
  • 2017-Present: Research Assistant Professor, University of Toledo, Department of Surgery, Toledo, Ohio

RESEARCH INTEREST

  1. My graduate and postgraduate researched was focused on understanding the mechanisms underlying the progression of the autoimmune disease Type-1 Diabetes.      
  2. Currently, I am working on understanding the post injury signaling response, known as neointimal hyperplasia, which occurs within the vascular wall.  

PUBLICATIONS

 

  1. Mohammad MK*, Morran MP*, Slotterbeck BD, Leaman DW, Sun Y, Grafestein H, Hong SC, and McInerney MF. “Dyregulated Toll-like receptor expression and signaling in bone marrow-derived macrophages at the onset of diabetes in the non-obese diabetic mouse.” Int Immunol. 18(7): 1101-13, 2006.
  2. Morran MP, McInerney MF, and Pietropaolo M. “Innate and Adaptive Autoimmunity in Type 1 Diabetes.” Pediatr Diabetes.  9(2): 152-61, 2008.
  3. Morran MP,Omen GS, Pietropaolo M. “Immunology and genetics of type 1 diabetes.”  Mt Sinai J Med.  75(4):  314-27, 2008.
  4. McInerney MF, Alexander LA, Morran MP and Pietropaolo M. ”Innate Immunity, Toll-like Receptors, and Diabetes.” Curr Immunol Rev2009, 5:111-121.
  5. Morran MP, Alexander LA, Slotterbeck BD, and McInerney MF. “Dysfunctional innate immune responsiveness to Porphyromonas gingivalis lipopolysaccharide in diabetes.”  Oral Microbiol Immunol. 24(4):  331-9, 2009.
  6. Morran MP, Casu A, Arena VC, Pietropaolo S, Zhang YJ, Satin LS, Nelson P, Omenn GS, Trucco M, Becker DJ, and Pietropaolo M.  “Humoral autoimmunity against the extracellular domain of the neuroendocrine autoantigen IA-2 heightens the risk of type 1 diabetes.”  Endocrinology. 151(6):  2528-37, 2010.
  7. Bonner SM, Pietropaolo S, FanY, Chang Y, Sethupathy P, Morran MP, Beems M, Pietropaolo M, et al. “Sequence Variation in Promoter of Ica1 Gene, Which Encodes Protein Implicated in T1D, Causes Transcription Factor Autoimmune Regulator (AIRE) to Increase Its Binding and Down-regulate Expression.” J Biol Chem.2012, 287(21):17882-93.
  8. Morran MP. “Lengel’s Legacy” The CrossFit JournalJan. 2013: http://library.crossfit.com/free/pdf/CFJ_Lengel_Morran_2.pdf.
  9. Morran MP, Vonberg A, Khadra A, and Pietropaolo M. “Immunogenetic of type 1 diabetes mellitus.” Mol Aspects Med. 2015, 42: 42-60.
  10. Acevedo-Calado M, James EA, Morran MP, Pietropaolo S, Ouyang Q, Arribas-Layton D, Songini M, Liguori M, Casu A, Auchus RJ, Huang S, Yu L, Michels A, Gianani R, Pietropaolo M. “Identification of unique antigenic determinants in the amino-terminus of IA-2 (ICA512) in childhood and adult autoimmune diabetes: New Biomarker Development.” Diabetes Care. 2017, 40(4):561-568.
  11. Morran MP, Al-Dieri A, Kalinoski A, Jordan RK, Gupta NK, McInerney MF. “Insulin receptor based lymphocyte trafficking in the progression of type 1 diabetes.” J Biol Methods. 2018, 5(1):e85.
  12. Acevedo-Calado MJ, Pietropaolo SL, Morran MP, Schnell S, Vonberg A, Verge CF, Gianani R,Becker DJ, Huang S, Greenbaum CJ, Yu L, Davidson HW, Michels AW, Rich SS, Pietropaolo M: Type 1 Diabetes TrialNet Study Group “Autoantibodies Directed to a Novel IA-2 Variant Protein Enhance Prediction of Type 1 Diabetes.” Diabetes. 2019 Sep;68(9):1819-1829.
  13. Nandedkar-Kulkarni N, Vartak AR, Sucheck SJ, Wall KA, Quinn A, Morran MP, McInerney MF: “Development of a bioconjugate platform for modifying the immune response of autoreactive cytotoxic T lymphocytes involved in type 1 diabetes.” Bioconjugate Chem. 2019, 30, 2049-2059.
  14. Gordon DM, Neifer KL, Hamoud AA, Hawk CF, Nestor-Kalinoski AL, SA Miruzzi, Morran MP, Adeosun SO, Sarver FG, Erhardt PW, McCullumsmith RE, Stec DE, Hinds TD: “Bilirubin remodels murine white adipose tissue by reshaping mitochondrial activity and the coregulator profile of peroxisome proliferator-activated receptor α” JBC 2020, DOI: 10.1074/jbc.RA120.013700.
  15. Pollard CA, Morran MP, Nestor-Kalinoski AL: “The COVID-19 pandemic: a globak health crisis.” Physiol Genomics 2020, 52 (11) 549-557. https://doi.org/10.1152/physiolgenomics.00089.2020.
  16. Nandedkar-Kulkarni N, Esakov E, Gregg B, Atkinson MA, Rogers DG, Horner JD, Singer K, Lundy SK, Felton JL, Al-Huniti T, Nestor-Kalinoski AL, Morran MP, Gupta NK, Bretz JD, Balaji S, Chen T, McInerney MF: “Insulin Receptor-Expressing T Cells Appear in Individuals at Risk for Type 1 Diabetes and Can Move into the Pancreas in C57BL/6 Transgenic Mice.” J Immunol 2021, 206 (7) 1443-1453. DOI: https://doi.org/10.4049/jimmunol.1900357.
  17. Morgan EE, Morran MP, Horen NG, Weaver DA, Andrea L Nestor-Kalinoski AL: “RNO3 QTL Regulates Vascular Structure and Arterial Stiffness in the Spontaneously Hypertensive Rat.” Physiol Genomics 2021, 1;53 (12):534-545. DOI: 10.1152/physiolgenomics.00038.2021.
Last Updated: 10/26/22