University of Toledo Integrated Core Facilities (ICF)

Michael P. Morran, Ph.D.

Michael Morran, Ph.D. Research Assistant Professor
Department of Surgery, College of Medicine and Life Sciences
Office: 419.383.6028
Email: Michael.morran@utoledo.edu

EDUCATION

B.S., Biology, University of Toledo, Toledo, Ohio 2002
Ph.D., Medicinal Biological Chemistry, University of Toledo, Toledo, Ohio, 2006

POSTGRADUATE TRAINING

  • University of Michigan, Department of Internal Medicine, Ann Arbor, Michigan 2007-2012

ACADEMIC APPOINTMENTS

  • 2002-2005: Teaching Assistant, University of Toledo, Department of Medicinal Biological Chemistry, Toledo, Ohio 
  • 2002-2006: Research Assistant, University of Toledo, Department of Medicinal Biological Chemistry, Toledo, Ohio 
  • 2007- 2012: Research Fellow, University of Michigan, Department of Internal Medicine, Ann Arbor, Michigan 
  • 2012- 2014: Research Investigator, University of Michigan, Department of Internal Medicine, Ann Arbor, Michigan 
  • 2014- 2017: Research Assistant Professor, University of Toledo, Department of Medicinal Biological Chemistry, Toledo, Ohio
  • 2017-Present: Research Assistant Professor, University of Toledo, Department of Surgery, Toledo, Ohio

RESEARCH INTEREST

  1. My graduate and postgraduate researched was focused on understanding the mechanisms underlying the progression of the autoimmune disease Type-1 Diabetes.      
  2. Currently, I am working on understanding the post injury signaling response, known as neointimal hyperplasia, which occurs within the vascular wall.  

PUBLICATIONS

 

  1. Mohammad MK*, Morran MP*, Slotterbeck BD, Leaman DW, Sun Y, Grafestein H, Hong SC, and McInerney MF. “Dyregulated Toll-like receptor expression and signaling in bone marrow-derived macrophages at the onset of diabetes in the non-obese diabetic mouse.” Int Immunol. 18(7): 1101-13, 2006.
  2. Morran MP, McInerney MF, and Pietropaolo M. “Innate and Adaptive Autoimmunity in Type 1 Diabetes.” Pediatr Diabetes.  9(2): 152-61, 2008.
  3. Morran MP,Omen GS, Pietropaolo M. “Immunology and genetics of type 1 diabetes.”  Mt Sinai J Med.  75(4):  314-27, 2008.
  4. McInerney MF, Alexander LA, Morran MP and Pietropaolo M. ”Innate Immunity, Toll-like Receptors, and Diabetes.” Curr Immunol Rev2009, 5:111-121.
  5. Morran MP, Alexander LA, Slotterbeck BD, and McInerney MF. “Dysfunctional innate immune responsiveness to Porphyromonas gingivalis lipopolysaccharide in diabetes.”  Oral Microbiol Immunol. 24(4):  331-9, 2009.
  6. Morran MP, Casu A, Arena VC, Pietropaolo S, Zhang YJ, Satin LS, Nelson P, Omenn GS, Trucco M, Becker DJ, and Pietropaolo M.  “Humoral autoimmunity against the extracellular domain of the neuroendocrine autoantigen IA-2 heightens the risk of type 1 diabetes.”  Endocrinology. 151(6):  2528-37, 2010.
  7. Bonner SM, Pietropaolo S, FanY, Chang Y, Sethupathy P, Morran MP, Beems M, Pietropaolo M, et al. “Sequence Variation in Promoter of Ica1 Gene, Which Encodes Protein Implicated in T1D, Causes Transcription Factor Autoimmune Regulator (AIRE) to Increase Its Binding and Down-regulate Expression.” J Biol Chem.2012, 287(21):17882-93.
  8. Morran MP. “Lengel’s Legacy” The CrossFit JournalJan. 2013: http://library.crossfit.com/free/pdf/CFJ_Lengel_Morran_2.pdf.
  9. Morran MP, Vonberg A, Khadra A, and Pietropaolo M. “Immunogenetic of type 1 diabetes mellitus.” Mol Aspects Med. 2015, 42: 42-60.
  10. Acevedo-Calado M, James EA, Morran MP, Pietropaolo S, Ouyang Q, Arribas-Layton D, Songini M, Liguori M, Casu A, Auchus RJ, Huang S, Yu L, Michels A, Gianani R, Pietropaolo M. “Identification of unique antigenic determinants in the amino-terminus of IA-2 (ICA512) in childhood and adult autoimmune diabetes: New Biomarker Development.” Diabetes Care. 2017, 40(4):561-568.
  11. Morran MP, Al-Dieri A, Kalinoski A, Jordan RK, Gupta NK, McInerney MF. “Insulin receptor based lymphocyte trafficking in the progression of type 1 diabetes.” J Biol Methods. 2018, 5(1):e85.
Last Updated: 2/12/20