Z. Kevin Pan, M.D., Ph.D.
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Professor and Chairman Molecular mechanisms of host-pathogen interactions Office: HEB 229B |
-The structural features of the innate immune receptors and the structural changes by which binding of a microbial ligand to the receptor leads to intracellular signaling cascades. -Negative feedback regulation of inflammatory responses, including septic shock, rheumatoid arthritis, and airway inflammation. -G protein-coupled chemoattrant receptors function and biology. Dr. Pan received his M.D. and Ph.D. in 1991 at the Shanghai Second Medical University. After postdoctoral training in the Department of Immunology at The Scripps Research Institute (La Jolla, CA), he was appointed to the faculty of the Molecular and Experimental Medicine Department at The Scripps Research Institute. Dr. Pan joined the Department of Medical Microbiology and Immunology in 2003. Current Grant Funding: Prior Grant Funding: "LPS Signaling and Lung Innate Immunity" "LPS, Alveolar Macrophages & Asthmatic Inflammation" (Project 3)
Recent Publications: Franco JH, Chen X, Pan ZK. Novel Treatments Targeting the Dysregulated Cell Signaling Pathway during Sepsis. J Cell Signal. 2021 Dec;2(4):228-234. Yao YM, Osuchowski MF, Wang JH, Pan ZK. Editorial: Immune Dysfunction: An Update of New Immune Cell Subsets and Cytokines in Sepsis. Front Immunol. 2021 Dec 16;12:822068. doi: 10.3389/fimmu.2021.822068. eCollection 2021.PMID: 34975929 Chen X, Liu Y, Dolin H, Liu J, Jiang Y, Pan ZK. Pinaverium Bromide Attenuates Lipopolysaccharide-Induced Excessive Systemic Inflammation via Inhibiting Neutrophil Priming. J Immunol. 2021 Apr 15;206(8):1858-1865. doi: 10.4049/jimmunol.1900975. Epub 2021 Mar 26. J Immunol. 2021. PMID: 33771933 Creeden JF, Imami AS, Eby HM, Gillman C, Becker KN, Reigle J, Andari E, Pan ZK, O'Donovan SM, McCullumsmith RE, McCullumsmith CB. Fluoxetine as an anti-inflammatory therapy in SARS-CoV-2 infection. Biomed Pharmacother. 138:111437. doi: 10.1016/j.biopha.2021.111437. Epub 2021 Feb 25. Lu X, Wang J, Chen X, Jiang Y, Pan ZK. Rolipram Protects Mice from Gram-negative Bacterium Escherichia coli-induced Inflammation and Septic Shock. Scientific Reporters; 10(1):175. doi: 10.1038/s41598-019-56899-6. 2020 Dolin HH, Papadimos TJ, Chen X, and Pan ZK. Characterization of pathogenic sepsis etiologies and patient profiles: a novel approach to triage and treatment. Microbiology Insights 12: 1-8. 2019. Liu Y, Ota T, Chen X, Dolin H, Pan K, Takashima A, Hinohara A, Pan ZK. Gene Expression Analysis on Neutrophil-Dendritic Hybrid Cells in Synovial Fluid from Rheumatoid Arthritis (RA) Patient. J Clin Cell Immunol 10: 575. doi:10.4172/2155-9899.1000575. 2019. Liu W, Pan K, Chen X, Dolin H, Chen G, Pan ZK. Synergistic Induction of CCL20 and Dendritic Cell Migration by Bacterial Chemoattractant fMLP and TLR2 Agonist: Roles of ERK/MAP Kinase. Clinical Microbiology: Open Access. 7:5 doi:10.4172/2327-5073. 1000316. 2018. Dolin HH, Papadimos TJ, Stepkowski S, Chen X, Pan ZK. A novel combination of biomarkers to herald the onset of sepsis prior to the manifestation
of symptoms. Shock. 49(4):364-370. doi: 10.1097/SHK.0000000000001010. 2018. |