Medical Microbiology and Immunology

Kevin Pan, M.D., Ph.D.


Professor and Chairman
Robert A. Stranahan Endowed Chair

Molecular mechanisms of host-pathogen interactions 

Office: HEB 200F
Office Phone Number: (419) 383-5466
E-mail Address:
Fax:  (419) 383-3002

-The structural features of the innate immune receptors and the structural changes by which binding of a microbial ligand to the receptor leads to intracellular signaling cascades.

-Negative feedback regulation of inflammatory responses, including septic shock, rheumatoid arthritis, and airway inflammation.

-G protein-coupled chemoattrant receptors function and biology.

Dr. Pan received his M.D. and Ph.D. in 1991 at the Shanghai Second Medical University. After postdoctoral training in the Department of Immunology at The Scripps Research Institute (La Jolla, CA), he was appointed to the faculty of the Molecular and Experimental Medicine Department at The Scripps Research Institute. Dr. Pan joined the Department of Medical Microbiology and Immunology in 2003.

Current Grant Funding:
Human Neutrophil-Dendritic Cell Hybrids
KHK, Co., Ltd.
Role: P.I.

Prior Grant Funding:
"Bacterial, Signaling & Leukocyte Transcription Activation"
Role: P.I.

"LPS Signaling and Lung Innate Immunity"
Role: P.I.

"LPS, Alveolar Macrophages & Asthmatic Inflammation" (Project 3)
NIH Program Project, PO1 NIAID AI-50498
Role" P.I. on Project 3


Representative Publications:

Dolin HH, Papadimos TJ, Chen X, and Pan ZK.   Characterization of pathogenic sepsis etiologies and patient profiles: a novel approach to triage and treatment. Microbiology Insights    12: 1-8. 2019.

Liu Y, Ota T, Chen X, Dolin H, Pan K, Takashima A,  Hinohara A, Pan ZK.  Gene Expression Analysis on Neutrophil-Dendritic Hybrid Cells in Synovial Fluid from Rheumatoid Arthritis (RA) Patient.  J Clin Cell Immunol 10: 575. doi:10.4172/2155-9899.1000575. 2019.

Liu W, Pan K, Chen X, Dolin H, Chen G, Pan ZK. Synergistic Induction of CCL20 and Dendritic Cell Migration by Bacterial Chemoattractant fMLP and TLR2 Agonist: Roles of ERK/MAP Kinase. Clinical Microbiology: Open Access. 7:5 doi:10.4172/2327-5073. 1000316. 2018.

Dolin HH, Papadimos TJ, Stepkowski S, Chen X, Pan ZK. A novel combination of biomarkers to herald the onset of sepsis prior to the manifestation of symptoms. Shock. 49(4):364-370. doi: 10.1097/SHK.0000000000001010. 2018.

Pan Y, Xu C, Pan ZK. MKP-1 negative regulates Staphylococcus aureus induced inflammatory responses in Raw264.7 cells: roles of PKA-MKP-1 pathway and enhanced by rolipram. Scientific Reporters; 7(1):12366. doi: 10.1038/s41598-017-10187-3. 2017.

Jiang Y, Smith L, Pan W, Chen X, Huang s, Pan ZK. Bacterial chemoattractant synergizes with LPS to induceinflammation via upregulating TLR4. Int J Clin Expe Med. 9(3):6005-6013, 2016.

Hong S, Noh H, Chen H, Padia R, Pan ZK, Su SB, Jing Q, Ding HF, Huang S. Signaling by p38 MAPK stimulates nuclear localization of the microprocessor component p68 for processing of selected primary microRNAs. Science Signal. Mar 12;6(266):ra16. doi: 10.1126/scisignal.2003706. 2013.

Xu X, Steere RR, Fedorchuk CA, Pang J, Lee JY, Lim JH, Xu H, Pan ZK. Maggirwar SB, Li JD. Activation of epidermal growth factor receptor is required for NTHi-induced NK-κB-dependent inflammation. PLoS One. 6(11):e28216. 2011.

Pan ZK., Fisher C, Li JD, Jiang Y, Huang S, Chen LY.   Bacterial LPS up-regulated TLR3 expression is critical for antiviral response in human monocytes: evidence for negative regulation by CYLD.   Int Immunol. 23(6):357-64. 2011.

Doerner AM, Chen LY, Ye RD, Yong J, Huang S, Pan ZK. Cell type-specific release of matrix-metallo-proteinase-9 by bacterial chemoattractant in human blood phagocytic leukocytes. Int J Clin Exp Med. 4(1):67-73. 2011.

Pan WW, Li JD, Huang S, Papadimos TJ, Pan ZK*. Chen LY. Synergistic activation of NF-kB by bacterial chemoattractant and TNFa is mediated by p38 MAPK-dependent RelA acetylation.   J Biol Chem. 285(45):34348-54. 2010. * corresponding author.

Mukherjee, S, Chen, L-Y, Papadimos, TJ, Zuraw BL, and Pan, ZK. (2009) LPS driven Th2 cytokine production in monocytes/macrophages is regulated by MyD88 and TRAM. J. Biol. Chem. 23;284(43):29391-8.

Chen, L-Y, Pan, ZK. (2009) Synergistic Activation of Leukocytes by Bacterial Chemoattractants:Potential Drug Targets. Endocr Metab Immune Disord Drug Targets. Dec 1;9(4):361-370.
Bohman, KD, Papadimos, TJ, Gottwald, LD, and Pan, ZK. (2009) Perniosis (chilblains) masquerading as CA-MRSA: a case report. CASES J. 29;2:6500.

XS Huang, L-Y Chen, AM Doerner, WW Pan, S Huang, TJ Papadimos, and ZK Pan. (2009) An atypical protein kinase C (PKCzeta) plays a critical role in LPS-activated NF-kappaB in human peripheral blood monocytes and macrophages.   J. Immunol. 182(9):5810-5.

L-Y Chen, WW Pan, M. Chen, J-D Li, W Liu, G Chen, S Huang, TJ Papadimos, and Pan, ZK. (2009) Synergistic induction of inflammation by bacterial products LPS and fMLP: An importanat microbial pathogenic mechanism.   J. Immunol. 182(4):2518-2524.

Papadimos TJ, Smith L, Mukherjee S, Popovic D, Chen LY, Pan ZK. (2006) A lack of toll-like receptor 4 expression variability in the immediate preoperative period: a pilot study of elective surgical patients. Eur J Anaesthesiol. 23(10):892-3.

Chen L-Y, Doerner A., Lehmann P.F., Huang S., Zhong G., and Pan ZK. (2005) A Novel Protein Kinase C Is a Signaling Component Downstream of GTPase RhoA and Mediates Chemoattractant-induced NF-kB Activation in Human Blood Monocytes. J. Biol. Chem. 280:22497-22501.

Joko H., Lim, J.H., Chen, L-F., Xu, H., Trompouki, E., Pan, Z.K., Mosialos, G., Li, J. (2004) NF-kB is essential for induction of CYLD, the negative regulator of NF-kB: evidence for a novel inducible auto-regulatory feedback pathway.   J. Biol. Chem. 279:36171-36174.

Chen, L-Y., Ptasznik, A., and Pan, Z.K. (2004) RhoA and Rac1 signals in fMLP-induced NF-kB activation in human blood monocytes.   Biochem. Biophys. Res. Commun. 319:629-635.

Bian, D., Su, S., Mahanivong, C., Cheng, R.K., Han, Q., Pan, Z.K., Sun, P., and Huang, S. (2004) Lysophosphatidic acid stimulates ovarian cancer cell migration via a Ras-MEK kinase 1 pathway.   Cancer Res.,64:4209-4217.

Chen, L-Y., Zuraw, B.L., Ye, R.D. and Pan, Z.K. (2004) A Rho exchange factor mediates fMet-Leu-Phe-induced NF-kB activation in human peripheral blood monocytes.   J. Biol. Chem. 279:7208-7212.

Su, H., McClarty, G., Dong, F., Hatch, G., Pan, ZK., and Zhong, G. (2004) Activation of Raf/MEK/ERK/cPLA2 signaling pathway is essential for chlamydial acquisition of host glycerophospholipids.   J. Biol. Chem. 279:9409-9416.

Pan, Z.K. (2004) Toll-like receptors (TLRs) and TLR-mediated signaling: more questions than answers.   Am. J. Physiol. 286:L918-920.

Chen, L-Y., Zuraw, B.L., Zhao, M., Liu, F-T., Huang, S., and Pan, Z.K. (2003) Involvement of protein tyrosine kinase in Toll-like receptor 4 (TLR4)-mediated NF-kB activation in human peripheral blood monocytes.  Am. J. Physiol., 284:L607-L613.

Chen, L-Y., Zuraw, B.L., Liu, F-T., Huang S., and Pan, Z.K. (2002) IL-1 Receptor-associated kinase and GTPase RhoA signal molecules are required for bacterial lipopolysaccharide (LPS)-induced cytokine gene transcription.   J. Immunol., 169:3934-3939.

Ptasznik, A., Chinta, S., Costa, M.A., Kalota, A., Swider, C.R., Katz, B.A., Demir, G., Pan, Z.K., and Gewirtz, A.M. (2002) Crosstalk between BCR/ABL oncoprotein and CXCR4 signaling through a Src family kinase in human leukemia cells.   J. Exp. Med., 196:667-678.

Christiansen, S., Eddleston, J., Woessner, K., Chambers, S., Ye, R.D., Pan, Z.K., and Zuraw, B.L. (2002) Upregulation of functional B1 bradykinin receptors in allergic airway inflammation. J. Immunol., 169:2054-2060.

Chen, J., Bakersville, C., Han, Q., Pan, Z.K., and Huang, S. (2001) av integrin, p38 mitogen-activated protein kinase and urokinase plasminogen activator are functionally linked in invasive breast cancer cells.   J. Biol. Chem., 276:47901-47905.

Huang, S., Chen, L-Y., Zuraw, B.L., Ye, R.D., and Pan, Z.K. (2001) Chemoattractant-stimulated NF-kB activation is dependent on the low molecular weight GTPase RhoA.   J. Biol. Chem., 276:40977-40981.

Pan, Z.K., Chen, L.Y., Cochrane, C.G., Zuraw, B.L. (2000) fMet-Leu-Phe stimulates proinflammatory cytokine gene expression in Human Peripheral Blood Monocytes: the Role of Phosphatidylinositol 3-kinase.   J. Immunol., 164:404-411.

Pan, Z.K., Christiansen, S., Ptasznik, A., Zuraw, B.L. (1999) Requirement of PI 3-kinase activity for bradykinin stimulation of NF-B activation in cultured human epithelial cells.   J. Biol. Chem., 274:9918-9922.

Pan, Z.K. (1998) Anaphylatoxin C5a and C3a Induce NF-B activation in Human Peripheral Blood Monocytes.   Biochem. Biophys. Acta., 1443:90-98.

Pan, Z.K., Ye, R.D., Christiansen, S.C., Jagels, M.K., Bokoch, G.M., Zuraw, B.L. (1998) Role of the Rho GTPase in bradykinin stimulated NF-B activation and interleukin-1 gene expression in cultured human epithelial cells.   J. Immunol., 160:3038-3045.

Pan, Z.K., Zuraw, B., Lung, C. Prossnitz, E.R., Browning, D., Ye, R.D. Bradykinin stimulates NF-kB activation and cytokine gene expression in cultured human fibroblasts.   J. Clin. Invest.   98:2042-2049, 1996

Pan, Z., Kravchenko, V.V., Ye, R.D. Platelet-activating factor stimulates transcription of the heparin-binding EGF-like growth factor in monocytes. Correlation with an increased kB binding activity. J. Biol. Chem. 270: 7787-7790, 1995


Last Updated: 7/17/19