DAYANIDHI RAMAN, B.V.Sc., Ph. D.
Associate Professor, Dept. Cell and Cancer Biology
dayanidhi.raman@utoledo.edu
EDUCATION:
| B.V. Sc. | 1988 | Veterinary Medicine |
Madras Veterinary College, Chennai, India |
| Ph. D. | 1995 | Biochemistry |
Kansas State University, Manhattan, KS, USA |
| Post - Doc | 2003 | GPCR Regulation |
UNC at Chapel Hill, North Carolina, NC, USA. |
RESEARCH INTERESTS:
Our long-term goal is to dissect the role of CXC chemokine receptors in breast cancer
stemness in metastatic triple-negative breast cancer (mTNBC). Currently, we are interested
in targeting many signaling nodes downstream of CXCR4 in combination with other vulnerable,
actionable molecular targets in in vitro and preclinical orthotopic mouse models. We also work on PK/PD of the drug combinations
and any attendant toxicities involved by testing them in immunocompetent mice and
zebra fish.
FUNDING:
Ongoing Research Support
1R01CA258682-01A1 National Cancer Institute
Raman (PI)
Targeting eIF4A1 in drug-resistant breast cancer stem-like cells
08/09/2022-07/31/2027
1R21CA256462-01A1 National Cancer Institute
Raman (PI)
01/01/2022 - 01/01/2024
Targeting of eIF4A along with immunotherapy to overcome chemoresistance
1 W81XWH-21-1-0053 (BC200858) Department of Defense - Breast Cancer Research Project
Tiwari (PI)
01/01/21 - 12/31/23
Unconventional cell death induction to target apoptosis-resistant TNBCs
Role: Co-I
Completed Research Support
University of Toledo, Medical Research Society
12/9/21-12/31/22
Targeting eIF4A1 in drug-resistant breast cancer stem-like cells
Role: PI
Ohio Cancer Research Foundation
07/01/2017 - 06/30/2019
Role of CXCR4-LASP1 axis in modulating the activity of Argonaute2-TNRC6 axis in breast
cancer cells
Role: PI
7R21CA202176-02 National Cancer Institute
12/01/2015 - 12/31/2017
An epigenetic link from CXCL12- CXCR4 axis through nuclear LASP1 in breast cancer
Role: PI
W81XWH-11-1-0413 Department of Defense (DOD) Breast Cancer IDEA grant
7/1/2011-6/30/2014
A co-activator role for chemokine-mediated nuclear translocated LASP1 in breast cancer
Role: PI
PUBLICATIONS:
Student Openings – Currently accepting Ph.D., M.D./Ph.D., and M.S.M.D. students