Department of Cancer Biology

Kam C. Yeung, Ph.D.


Kam C. Yeung, Ph.D.
Associate Professor of Cancer Biology


Together with John Sedivy (Brown University) and Walter Kolch (Systems Biology Ireland & Conway Institute University College Dublin), we identified and named RKIP as one of the metastasis suppressor genes of breast and prostate cancer. Studies with transplantation mouse models demonstrated that RKIP inhibits cancer metastasis by modulating the expression of multiple metastasis genes. Unlike other classical tumor suppressor genes, which usually have complete loss-of-function mutations in tumor cells, RKIP is not mutated but merely silenced in cancer. Importantly, we demonstrated that the low expression levels of RKIP could be re-activated. In view of its role as a master modulator or expression of multiple metastasis genes and its expression being able to be re-active, RKIP represents a novel therapeutic target for patients afflicted with metastatic cancer. To utilize this potential, the major focus of the lab is to understand the molecular mechanism through which RKIP exerts its control over multiple metastasis genes. To have immediate therapeutic gains in treatment of cancer metastasis, we are also interested in developing methods to restore expression of RKIP in cancers.


B.Sc.   1986    Basic Medical Sciences, University of South Alabama, Mobile, AL
Ph.D.  1990    Microbiology, University of South Alabama, Mobile, AL
1990-1992    Post-Doc, Molecular Virology, University of Iowa, Iowa City, IA
1992-1996    Post-Doc, Biochemistry, Howard Hughes Medical Institute/UMDNJ, Piscataway, NJ


2017-pres.  Assoc Professor, Dept. of Cancer Biology, Univ of Toledo College of Medicine & Life Sciences, Toledo, OH
2009-2017 Assoc Professor, Dept. of Biochemistry & Cancer Biology, Univ of Toledo College of Medicine & Life Sciences, Toledo, OH
2001-2009 Assistant Professor, Dept. of Biochemistry & Cancer Biology, Univ of Toledo Health Science Campus, Toledo, OH
1996-2001 Research Assistant Professor, Dept. of Molecular Biology, Cell Biology & Biochemistry, Brown Univ, Providence, RI 






Last Updated: 2/12/20