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Francis X. Pizza, Ph.D.
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Francis X. Pizza, Ph.D.
Research Interest
Our research focuses on the inflammatory response in skeletal muscle after injurious and non-injurious exercise. We are particularly interested in determining the contribution of inflammatory cells (neutrophils and macrophages) to exercise-induced muscle injury, repair/regeneration, and hypertrophy. We are also interested in determining the mechanisms by which exercise modulates neutrophil and macrophage activation in skeletal muscle. We use human, rodent, and cell culture models and contemporary laboratory techniques to answer basic and applied questions in these areas.
Information on our research facilities can be found at the link below:
Education
Ph.D. Exercise Physiology. The University of Toledo, Toledo, Ohio, 1991
M.A. Exercise Physiology. Adelphi University, Garden City, New York, 1988
B.E. Human Performance. The University of Toledo, Toledo, Ohio, 1986
Professional Experience
2004 – Present Professor, The University of Toledo, Dept. Kinesiology.
Toledo, OH.
1998 - 2004 Associate Professor, The University of Toledo, Dept.
Kinesiology. Toledo, OH.
1997 - 1998 Associate Professor, Texas Christian University,
Dept. of Kinesiology Fort Worth, Texas.
1996 - 1997 Research Associate in Space Biology, University of
California at Los Angeles. Dept. of Physiological Science.
Muscle Cell Biology Lab.
1991 - 1996 Assistant Professor, Texas Christian University, Dept.
of Kinesiology. Fort Worth, Texas.
Selected Publications
Peterson, JM, FX Pizza. Cytokines derived from cultured skeletal muscle cells after mechanical strain promote neutrophil chemotaxis in vitro. Journal of Applied Physiology 106: 130-137, 2009.
Koh, TJ, FX Pizza. Do inflammatory cells influence skeletal muscle hypertrophy? Frontiers in Bioscience E1: 60-71, 2009
Marino, JS, B J Tausch, CL Dearth, MV Manacci, TJ McLoughlin, SJ Rakyta, MP. Linsenmayer, FX. Pizza. β2 integrins contribute to skeletal muscle hypertrophy in mice. American Journal of Physiology Cell Physiology 295: C1026-C1036, 2008
Peterson, JM, K.D. Feeback, J.H. Baas, F.X. Pizza. Tumor necrosis factor-alpha promotes the accumulation of neutrophils and macrophages in skeletal muscle. Journal of Applied. Physiology. 101: 1394-1399, 2006
Pizza, FX. Immunology. In: American College of Sports Medicine Guidelines for Exercise Testing and Prescription. 7th edition. (2006) Lippincott Williams & Wilkins (invited section to chapter 9)
Pizza, F.X., J. M. Peterson, J. H. Baas, and T.J. Koh. Interplay between neutrophils and skeletal muscle after exercise. What’s going on? Physiology News 61: 32-33, 2005
Tsivitse, S.K., E. Mylona, J.M. Peterson, W.T. Gunning, and F.X. Pizza . Mechanical loading and injury induce human myotubes to release neutrophil chemoattractants. American Journal of Physiology Cell Physiology 288: C721-C729, 2005.
Pizza, F.X., J. M. Peterson, J. H. Baas, and T.J. Koh. Neutrophils contribute to muscle injury and impair its resolution after lengthening contractions in mice. Journal of Physiology (London) 562.3: 899-913, 2005
McLouglin, T.J., A.R. Snyder, and F.X. Pizza. Aggressive application of monophasic high voltage stimulation provides a transitory reduction in delayed onset muscle soreness after injurious exercise. British Journal of Sports Medicine 38(6):725-729, 2004.
McLoughlin, T.J., S.K. Tsivitse, J.A. Edwards, B.A. Aiken, and F.X.Pizza. Deferoxamine reduces and nitric oxide synthesis inhibition increases neutrophil-mediated myotube injury. Cell and Tissue Research 313: 313-319, 2003.
Tsivitse, SK, T.J. McLoughlin, J. Peterson, E. Mylona, S.J. McGregor, and F.X. Pizza. Downhill running in rats: influence on muscle inflammatory cells and MyoD protein. European Journal of Applied Physiology 90: 633-638, 2003.
Koh, T.J., J. M. Petersen, F.X. Pizza, and S. V. Brooks. Passive stretches protect skeletal muscle from old and adult mice from lengthening contraction-induced injury. Journal of Gerontology: Biological Sciences 58A (7): 592-597, 2003.
McLoughlin, T.J., E. Mylona, T.A. Hornberger, K.A. Esser, F.X. Pizza. Inflammatory cells in rat skeletal muscle are elevated after electrically stimulated contractions. Journal of Applied Physiology 94: 876-882, 2003.
Peterson, J.M., T.A. Trappe, E. Mylona, F. White, C.P. Lambert, W.J. Evans, and F.X. Pizza. Ibuprofen and acetaminophen: effect on muscle inflammation after eccentric exercise in humans. Medicine Science Sports and Exercise 35(6): 892-896, 2003.
Pizza, F.X., T.J. Koh, S.J. McGregor, and S.V. Brooks. Muscle inflammatory cells following passive stretches, isometric contractions, and lengthening contractions. Journal of Applied Physiology 92: 1873-1878, 2002.
Frenette, J., M. St-Pierre, C. H. Cote, E. Mylona, and F. X. Pizza. Muscle impairment occurs rapidly and precedes inflammatory cell accumulation after mechanical loading. American Journal of Physiology. 282: R351-R357, 2002.
Pizza, F.X., T. McLoughlin, S. McGregor and W. Gunning. Neutrophils injure cultured skeletal muscle myotubes. American Journal of Physiology: Cell Physiolology 281: C335-C341, 2001.
Pizza, F.X., H. Baylies, J.B. Mitchell. Adaptation to eccentric exercise: Neutrophils and E-selectin during early recovery. Can. J. Appl. Physiol. 26(3): 245-253, 2001.
Pizza, F.X. D. Cavender, A. Stockard, H. Baylies, and A. Beighle. Anti-inflammatory doses of ibuprofen: effect on neutrophils and exercise-induced muscle injury. Int. J. Sports Med. 20: 98-102, 1999.
Pizza, F.X., I.J. Hernandez, and J.G. Tidball. Nitric oxide synthase inhibition reduces muscle inflammation and necrosis in modified muscle use. Journal of Leukocyte Biology 64: 427-433, 1998.
Mitchell, J.B., F.X. Pizza, A. Paquet, B.J. Davis, M.B. Forrest, and W.A. Braun. The influence of carbohydrate status on immune cell numbers and lymphocyte proliferation before and after endurance exercise. J. Appl. Physiol. 84(6): 1917-1925, 1998.
Pizza, F.X., B.H. Davis, S.D. Henrickson, J.B. Mitchell, J.F. Pace, N. Bigelow, P. DiLauro, and T. Naglieri. Adaptation to eccentric exercise: effect on CD64 and CD11b/CD18 expression. Journal of Applied Physiology 80(1): 47-55,1996.
Pizza, F.X., M.G. Flynn, T. Sawyer, R.D. Starling, M. Boyle, and F.A. Andres. Run Training vs. Cross Training: Effect of increased training on circulating leukocyte subsets. Med. Sci. Sports Exerc. 27(3):355-362, 1995.
Pizza, F.X., J.B. Mitchell, B. Davis, R.D. Starling, R. Holtz, and N. Bigelow. Exercise-induced muscle damage: effect on circulating leukocyte and lymphocyte subsets. Med. Sci. Sport Exerc. 27(3): 363-370, 1995.
Courses Taught
Human Physiology
Laboratory Techniques in Exercise Physiology
Laboratory Techniques in Exercise Biology
Skeletal Muscle Biology
Contact Information
Francis X. Pizza, Ph.D.
Department of Kinesiology
Mail Stop # 119
The University of Toledo
2801 W. Bancroft St
Toledo, Ohio 43606
Voice: (419) 530-4178
FAX: (419) 530-2477
Francis.Pizza@utoledo.edu
