| Tom McLoughlin, PhD, ATC |
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Assistant Professor, Department of Kinesiology
College: Health and Human Services
Office: HEC 238
Email: tmcloug@UTnet.utoledo.edu
Phone: 419-530-5982
Fax: 419-530-4759
Joined the Department of Kinesiology at The University of Toledo as an Assistant Professor of Exercise Physiology in January 2004.
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Research Scope:
Skeletal muscle is a highly adaptable tissue that responds to various mechanical, metabolic, and environmental demands through changes in morphology, plasticity, enzyme capacity, and/or cytosolic composition. These adaptations are accomplished through modulation in various molecular signaling cascades, resulting in transcriptional and translational alterations, changes in gene expression patterns, and select protein modifications. Skeletal muscle atrophy, a process characterized by increased protein degradation and a decrease in muscle size, is a manifestation of physical inactivity, aging, neuromuscular injury, and/or various disease processes. Understanding the molecular regulation and processes associated with skeletal muscle atrophy is necessary for attenuating losses in skeletal muscle mass and function associated with aging, injury, and various disease processes, and, ultimately, improving the overall quality of life in a multitude of individuals.
Current Research:
Involved in several projects investigating the molecular regulation of skeletal muscle growth and the maintenance of skeletal muscle mass associated with physical activity and inactivity. Specifically, Forkhead (FoxO) proteins constitute a sub-family of winged-helix transcription factors (i.e. FoxO1, FoxO3, and FoxO4) responsible for maintaining cell survival, proliferation and metabolic regulation. Currently, investigating the contribution of FoxO1 protein activation in the regulation of skeletal muscle mass, survivability, and influence on gene expression.
EDUCATION
Postdoctoral Research Associate , 10/01-12/03
The Muscle Biology Laboratory
The University of Illinois at Chicago, Chicago, Illinois 60608
Supervisor: Karyn A. Esser, Ph.D.
Doctor of Philosophy , Applied Physiology, 8/01
Minor: Research and Measurement
The University of Toledo, Toledo, Ohio 43606
Dissertation Title: Neutrophil-mediated skeletal myotube injury: the contribution of reactive oxygen and nitrogen intermediates
Master of Arts , Exercise Physiology, 8/96
Adelphi University, Garden City, New York 11530
Bachelor of Science , Athletic Training/Exercise Science, 5/95
Ithaca College, Ithaca, New York 14850
PUBLICATIONS
McLoughlin T.J. , S.K. Tsivitse, J.A. Edwards, B.A. Aiken, and F.X. Pizza. (2003). Deferoxamine reduces and nitric oxide synthase inhibition increases neutrophil-mediated myotube injury. Cell Tissue Res .313:313-319
McLoughlin, T.J. E. Mylona, T.A. Hornberger, K.A. Esser, and F.X. Pizza. (2003). Inflammatory cells in rat skeletal muscle are elevated after electrically stimulated contractions. J. Appl. Physiol. 94:876-882.
McLoughlin T.J ., A.R. Snyder, P.G. Brolinson, and F.X. Pizza. (2003). Effect of sensory level electrical stimulation on markers of muscle injury. Br. J. Sports Med . (in press)
Hornberger, T.A., T.J. McLoughlin et al. (2003). Selenoprotein-deficient transgenic mice exhibit enhanced exercise-induced muscle growth. J. Nutr. 133:3091-3097. (Co-first author)
Tsivitse S.K., T.J. McLoughlin , J. Peterson, E. Mylona, S.J. McGregor, and F.X. Pizza. (2003). Downhill running in rats: influence on neutrophils, macrophages, and MyoD+ cells in skeletal muscle. Eur. J. Appl. Physiol. 90:633-8.
Pizza F.X., T.J. McLoughlin , S.J. McGregor, E.P. Calomeni, and W.T. Gunning. Neutrophils injure cultured skeletal myotubes . Am. J. Physiol. 281: C335-C341, 2001.
Braun W.A., M.G. Flynn, D. Jacks, T. McLoughlin , J. Sowash, C.P. Lambert, E. Mylona, and M. Hansen. (1999). Indomethacin does not reduce NK cell cytotoxicity. J. Appl. Physiol. 87:2237-2243.
CERTIFICATIONS AND AFFILIATIONS
American College of Sports Medicine, Exercise Test Technologist
(6/96)
American College of Sports Medicine, Health Fitness Instructor
(5/96)
National Athletic Trainers Association, Board of Certification
(NATABOC), ATC
Member, American College of Sports Medicine
Member, National Athletic Trainers Association
Member, The American Physiological Society
LINKS
Department of Kinesiology Class Links
http://www.hhs.utoledo.edu/kinesiology/kine_classlinks.html
National Athletic Trainers' Association
www.nata.org
Federation of American Societies for Experimental Biology
www.faseb.org
American Physiological Society
http://www.aps.org/
American College of Sports Medicine
www.acsm.org
