The University of Toledo

Saturday, May 14, 2011

10:00 AM – 12:00 PM

Registration, Poster set up and buffet luncheon
Dana Center – Atrium

12:00 PM - 12:10 PM

Symposium Opening Remarks and Welcome
Stephan Patrick, Ph.D., Chair, and Kandace Williams, Ph.D., Co-Chair
Dana Center – Lucas Auditorium

12:10 PM - 1:10 PM

Keynote Lecture
Larry Loeb, M.D., Ph.D., University of Washington
Random Mutations in Human Cancers: Origins and Consequences

1:10 PM – 2:25 PM



1:10 PM - 1:25 PM



1:25 PM - 1:40 PM



1:40 PM - 1:55 PM



1:55 PM - 2:10 PM



2:10 PM - 2:25 PM

Oral Session I
DNA Repair Pathways
(5 presentations @ 12 min each & 3 min discussion)

Janice Ortega, University of Kentucky
PCNA Phosphorylation Inhibits Mismatch Repair and Induces Misincorporations During DNA Synthesis

Ye Peng, University of Pittsburgh
Defining the Search Mechanism of the UVRC-Nuclease for a UVRB-DNA Pre-Incision Complex at the Single Molecule Level

Elizabeth Spehalski, University of Michigan
Roles of the MRN Complex in the Maintenance of Genomic Stability Following AID-Induced Lesions

Alo Ray, The Ohio State University
DDB2 and XPC Positively Influence ATR and ATM Recruitment to the UV Damage Site and Regulate Downstream Signaling Pathways

Zalfa A. Abdel-Malek, University of Cincinnati
Regulation of H2AX Phosphorylation in Human Melanocytes by UV and A-Melanocyte Stimulating Hormone: Implications on DNA Repair and Genomic Stability

2:25 PM – 2:45 PM

Break

2:45 PM – 3:45 PM

Keynote Lecture
Laura Niedernhofer, M.D., Ph.D., University of Pittsburgh
The Good, the Bad and the Ugly Related to ERCC1-Deficiency

3:45 PM – 5:00 PM




3:45 PM - 4:00 PM



4:00 PM - 4:15 PM


4:15 PM - 4:30 PM



4:30 PM - 4:45 PM



4:45 PM - 5:00 PM

Oral Session II
Targeting DNA Repair as a Translational Approach to Improve Chemotherapy Treatment
(5 presentations @ 12 min each & 3 min discussion)

Siobhan Q. Gregg, University of Pittsburgh
Endogenous DNA Damage Drives Cellular Senescence and Promotes Mitochondrial Alterations

David Svilar, University of Pittsburgh
Alkylation Sensitivity Screens Reveal a Cross-Species Functionome

Aditi Nadkarni, Mayo Clinic
DNA-PK Inhibitor KU-60648 Radiosensitizes Glioblastoma Cells by Enhancing Radiation-Induced DNA Double-Stranded Breaks

Jennifer N. Earley, Indiana University School of Medicine
Structure/Function Analysis of Small Molecule Inhibitors of the Human SS-DNA Binding Protein, Replication Protein A (RPA)

Jason Glanzer, University of Nebraska Medical Center
Identification of Small Molecule Inhibitors of the N-Terminal Domain of RPA70 

5:00 PM – 7:30 PM

Poster Session
Dana Center – The Hotel at The University of Toledo connector

7:30 PM – 9:30 PM

Dinner - The Hotel at The University of Toledo Birch, Elm, Maple, Oak Rooms
Bernard S. Strauss, Ph.D., Professor Emeritus
The University of Chicago
50 Years of DNA Repair and Mutation Research

9:30 PM – 12:00 AM

Reception
The Hotel at The University of Toledo Faculty Club

Sunday, May 15, 2011

7:30 AM – 8:30 AM

Continental Breakfast
Dana Center – Atrium

8:30 AM – 9:30 AM



8:30 AM - 8:45 AM


8:45 AM - 9:00 AM



9:00 AM - 9:15 AM


9:15 AM - 9:30 AM

Oral Session III
DNA Double Strand Breaks and Chromosome Instability
(4 presentations @ 12 min each & 3 min discussion)

Sreejith Ramakrishnan, IUPUI
Effect of DNA Inverted Repeats on Repair of Double Strand Breaks

Cheryl Jacobs, University of Michigan
A Hypomorphic Artemis Human Disease Allele Causes Aberrant Chromosomal Rearrangements and Tumorigenesis

Xiaofeng Zhou, University of Michigan
Cell Fusion Causes DNA Double-Stranded Breaks and Cell Transformation

Michael Leffak, Wright State University
DNA Hairpin Formation and Replication-Dependent Instability at CTG•CAG Repeats in Human Cells

9:30 AM – 10:30 AM

Keynote Lecture
Graham Walker, Ph.D., Massachusetts Institute of Technology
Function and Control of Translesion DNA Polymerases

10:30 AM – 11:00 AM

Break

11:00 AM – 12:00 PM



11:00 AM - 11:15 AM




11:15 AM - 11:30 AM



11:30 AM - 11:45 AM



11:45 AM - 12:00 PM

Oral Session III
DNA Damage Response
(4 presentations @ 12 min each & 3 min discussion)

Dilip Jain, University of North Texas Health Science Center
Enhancement of Cellular Cisplatin Sensitivity by NSC109268 is Associated with Inhibition of Damage Tolerance by the RAD5 Template Switch Pathway and Detectable as S-Phase Delay

Jeffrey M. Buis, University of Michigan
Mre11 Controls Bidirectional Signaling Between DNA Repair and Cell Cycle Machineries

Sophia Shalhout, Wayne State University
A Direct Correlation between Hypermutations, High Levels of Activation-Induced Deaminase and Uracils in DNA of a B Cell Lymphoma Cell Line

Michael Kemp, University of North Carolina School of Medicine
The DNA Damage Response Kinases DNA-PK and ATM are Stimulated by Bulky Adduct-Containing DNA

12:00 AM – 12:30 PM

Presentation of Awards to Junior Scientists

Adjournment of 2011 Symposium