Physiology and Pharmacology

Ashok Kumar, Ph.D., FAHA

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Professor

Phone:  419-383-4520
Fax:      419-383-2871

E-mail: Ashok.Kumar2@utoledo.edu

Education

1960 -  M.Sc.   Organic Chemistry, Agra University, India
1963 -  Ph.D.   Biochemistry, Allahabad University, India


Post Doctoral Training

1964-1966    - National Chemical Laboratory, Poona (INDIA)
1966-1970    - Enzyme Research Institute, University of Wisconsin, Madison, WI.
                       Trained in the laboratory of Nobel Laureate, Prof. H.G. Khorana

Appointments

1970-1979

Assistant Professor, Department of Biochemistry, AIIMS, New Delhi

1979-1980

Research Associate, Department of Biochemistry, Worcester Foundation of Experimental Biology, Shrewsbury, MA

1980-1983

Research Associate Professor, Department of Structural Biology, University of Texas Health Science Center, San Antonio, TX

1984-1989

Research Associate Professor, Department of Human Biological Chemistry, University of Texas Medical Branch, Galveston, TX

1990-1994

Research Associate Professor, Department of Cell Biology and Anatomy, SUNY Health Science Center, Brooklyn, NY

1994-2004

Professor, Department of Pathology, New York Medical College, Valhalla, NY

2004-2011

Tenured Professor, Department of Pathology, New York Medical College, Valhalla, NY 

Fall 2011

Professor, Department of Physiology and Pharmacology, University of Toledo, Toledo, OH

Research Interests

Research interests include molecular genetics of hypertension, role of single nucleotide polymorphisms (SNPs) in human essential hypertension and pregnancy induced hypertension.


Representative Publications

  • Jain S, Tillinger A, Mopidevi B, Pandey VG, Chauhan C, Fiering SN, Warming S, Kumar A.  Transgenic mice with —6A haplotype of the human angiotensinogen gene have increased blood pressure compared to —6G haplotype.  J Biol Chem. 2010 Dec 24; 285(52):41172-41186.
  • Jain S, Vinukonda G, Fiering SN, Kumar A.  A haplotype of human antiotensinogen gene containing —217A increases blood pressure in transgenic mice compared with —217G.  Am J Physiol Regul Integr Comp Physiol. 2008 Dec;295: R1849-R1857. 
  • Jain S, Patil S, Li Y, Kumar A.  HNF-1 alpha plays an important role in IL-6 induced expression of the human angiotensinogen gene.  Am J Physiol Cell Physiol. 2007 293:C401-C410.
  • Velez DR, Guruju M, Vinukonda G, Prater A, Kumar A, Williams SM.  Angiotensinogen promoter sequence variants in essential hypertension.  Amer J of Hypertension. Dec 2006; 19:1278-1285.
  • Jain S, Shah M, Sehgal P and Kumar A.  Interferon –γ increases the expression of Human Angiotensinogen gene.  Biochimica Biophysica Acta. 1759:340-347 (2006).
  • Tang X , Guruju M, Rajendran GP, Isler CM, Martin JN Jr., and Kumar A.  Role of T825C Polymorphism of GN3 gene in Preeclampsia .  Hypertension in Pregnancy. 25:93-101 (2006).
  • Li Y, Jain S, Patil S, and Kumar A.   A haplotype of angiotensinogen gene is associated with essential hypertension and affects promoter activity in adipocytes.  Vascular Pharmacology. 44:29-33 (2006).
  • Markovic D, Lewinstein M, Ho J, Kumar A, and Ott J.  Association of angiotensinogen gene polymorphisms with essential hypertension in Africans and Caucasians. Human Heredity. 60:89-96 (2005).
  • Jain S, Li Y , Kumar A, Sehgal PB.  Transcriptional signaling from membrane raft-associated glucocorticoid receptor (GR).  Biochemical and Biophysical Research Communications, 336, 3-8 (2005).
  • Kumar A, Li Y, Patil S, Jain S.  A haplotype of the angiotensinogen gene is associated with hypertension in african americans. Clin Exp Pharmacol Physiol. 32:495-502, 2005.
  • Jain S, Li Y, Patil S, Kumar A.  A single-nucleotide polymorphism in human angiotensinogen gene is associated with essential hypertension and affects glucocorticoid induced promoter activity. J. Mol. Med. 83:21-131, 2005.
  • Jain S, Tang X, Narayanan CS, Agarwal Y, Peterson SM, Brown CD, Ott J, and Kumar A.  Angiotensinogen gene Polymorphism at -217 affects basal promoter activity and is associated with Hypertension in African-American Population.  J Biological Chemistry. 277: 36889-36896, 2002.
  • Narayanan CS, Cui Y, Kumar S, and Kumar A.   cAMP increases the expression of human angiotensinogen gene through a combination of cyclic AMP responsive element binding protein and a liver specific transcription factor. Molecular Cellular Biochemistry. 212:81-90, 2000.
  • Bhargava A, Kumar A, Yuan N, Gewitz MH, and Mathew R.  Monocrotaline induces Interleukin-6 mRNA in Rat Lungs. Heart Disease. 1:126-132, 1999.
  • Narayanan CS, Cui Y, Zhao YY, Zhou J, and Kumar A.  Orphan Receptor Arp-1 Binds to the Nucleotide Sequence Located Between TATA Box and Transcriptional Initiation Site of the  Human Angiotensinogen Gene and Reduces Estrogen Induced Promoter Activity. Mol. Cell. Endocrinology. 148: 79-86, 1999.
  • Zhao YY, Zhou J, Narayanan CS, Cui Y, and Kumar A.  Role of C/A Polymorphism at -20 on the Expression of Human Angiotensinogen Gene. Hypertension. 33: 108-115, 1999.
  • Cui Y, Narayanan CS, Zhou J, and Kumar A.  Exon-I is involved in positive as well as negative regulation of human angiotensinogen gene expression. GENE. 224: 97-107, 1998.

 

Last Updated: 3/23/15