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Recent Publications by Faculty of UT Biological Sciences

Department of Biological Sciences Publications 


  • Bamber, B.A. Baker C, Sturt BL, Multiple roles for the first transmembrane domain of GABAA receptor subunits in neurosteroid modulation and spontaneous channel activity. Neurosci Lett. 2010 473(3):242-7.
  • Chadee DN, Kyriakis JM. Activation of SAPK/JNKs in vitro. Methods Mol Biol. 2010;661:59-73.
  • Cheriyath, V., D.W. Leaman and E.C. Borden. (2010) Emerging Roles of FAM14 Family Members (G1P3 /ISG 6-16 and ISG12) in Innate Immunity and Cancer. J. Interferon and Cytokine Res.
  • Davis KM, Sturt BL, Friedmann AJ, Richmond JE, Bessereau JL, Grant BD, Bamber BA. Regulated lysosomal trafficking as a mechanism for regulating GABAA receptor abundance at synapses in Caenorhabditis elegans. Mol Cell Neurosci. 2010 44(4):307-17.
  • Fornalé S., Shi X., Chai, C., Encina A., Irar, S., Capellades M., Fuguet E., Torres J-L., Rovira P., Puigdomènech P., Rigau J., Grotewold E., Gray J., and Caparrós-Ruiz D. ZmMYB31 directly represses maize lignin genes and redirects the phenylpropanoid metabolic flux. The Plant Journal 64, (4), 633–644, 2010
  • Harris G, Mills H, Wragg R, Hapiak V, Castelletto M, Korchnak A, Komuniecki RW. The monoaminergic modulation of sensory-mediated aversive responses in Caenorhabditis elegans requires glutamatergic/peptidergic cotransmission. J Neurosci. 2010 30:7889-99.
  • He J, Gray J, Leisner S. A Pelargonium ARGONAUTE4 gene shows organ-specific expression and differences in RNA and protein levels. J Plant Physiol. 2010 167:319-25.
  • Kaur H, Bekier ME, Taylor WR. Regulation of Borealin by phosphorylation at serine 219. J Cell Biochem. 2010 Dec 1;111(5):1291-8.
  • Kullyev A, Dempsey CM, Miller S, Kuan CJ, Hapiak VM, KomunieckiRW, Griffin CT, Sze JY. (2010) A genetic survey of fluoxetine action on synaptic transmission in Caenorhabditis elegans. Genetics. Nov;186(3):929-41.
  • Linkes S, Fry C, Quinn A. Antigen-Experienced CD4lo T Cells Are Linked to Deficient Contraction of the Immune Response in Autoimmune Diabetes. Autoimmune Dis. 2010 Sep 29;2010:920148.
  • Liu Q, Basu S, Qiu Y, Tang F, Dong F. A role of Miz-1 in Gfi-1-mediated transcriptional repression of CDKN1A. Oncogene. 2010 29(19):2843-52.
  • Malathi K, Saito T, Crochet N, Barton DJ, Gale M Jr, Silverman RH. RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP. RNA. Nov;16(11):2108-19, 2010.
  • Messmer-Blust AF, Balasubramanian S, Gorbacheva VY, Jeyaratnam JA, Vestal DJ. The interferon-gamma-induced murine guanylate-binding protein-2 inhibits rac activation during cell spreading on fibronectin and after platelet-derived growth factor treatment: role for phosphatidylinositol 3-kinase. Mol Biol Cell. 2010 Jul;21(14):2514-28.
  • Vestal, D.J. and Jeyaratnam, J.A. (2010) The Guanylate-Binding Proteins (GBPs): Emerging insights into the biochemical properties and functions of this family of large interferon-induced GTPases. Journal of Interferon and Cytokine Research.
  • Zhan Y and Chadee DN. (2010) Inhibition of Cdc42-mediated activation of MLK3 by the tumor suppressor Merlin. Small GTPases 1:183-186.


  • Balasubramanian S, Fan M, Messmer-Blust AF, Yang CH, Trendel JA, Jeyaratnam JA, Pfeffer LM, Vestal DJ. (2011) The interferon-{gamma}-induced GTPase, mGBP-2, inhibits TNF-{alpha}-induction of matrix metalloproteinase-9 (MMP-9) by inhibiting NF-{kappa}B and Rac. J Biol Chem. 3;286(22):20054-64
  • Balasubramanian S, Messmer-Blust AF, Jeyaratnam JA, Vestal DJ. (2011) Role of GTP Binding, Isoprenylation, and the C-Terminal α-Helices in the Inhibition of Cell Spreading by the Interferon-Induced GTPase, Mouse Guanylate-Binding Protein-2. J Interferon Cytokine Res.
  • Bazeley PS, Nestor Kalinoski AL, Ways JA, Liu ST, Ramdath RS, Matsui SI, Allison DC. (2011) A model for random genetic damage directing selection of diploid or aneuploid tumours. Cell Prolif. Jun;44(3):212-23.
  • Dreier MR, Bekier ME 2nd, Taylor WR. (2011) Regulation of sororin by Cdk1-mediated phosphorylation. J Cell Sci. Sep 1;124(Pt 17):2976-87.
  • Frantz, JM., Khandekar, S. and S. Leisner. (2011) Silicon differentially influences Cu toxicity response in silicon-accumulator and non-accumulator species. J. A, Soc. Hort. Sci. 136:329-338.
  • Harris G, Korchnak A, Summers P, Hapiak V, Law WJ, Stein AM, Komuniecki P, Komuniecki R. (2011) Dissecting the serotonergic food signal stimulating sensory-mediated aversive behavior in C. elegans. PLoS One. 6(7):e21897.
  • Harris G, Korchnak A, Summers P, Hapiak V, Law WJ, Stein AM, Komuniecki P, Komuniecki R. (2011) Dissecting the serotonergic food signal stimulating sensory-mediated aversive behavior in C. elegans. PLoS One. 6(7):e21897.
  • Hu S, Pawson T, Steven RM. (2011) UNC-73/Trio RhoGEF-2 Activity Modulates Caenorhabditis elegans Motility Through Changes in Neurotransmitter Signaling Upstream of the GSA-1/G{alpha}s Pathway. Genetics. Sep;189(1):137-51.
  • Khandekar S, Leisner S. (2011) Soluble silicon modulates expression of Arabidopsis thaliana genes involved in copper stress. J Plant Physiol. 168(7):699-705.
  • Kiraly A, Koffman B, Hacker M, Gunning W, Rasche S, Quinn A. (2011) A novel aza-anthrapyrazole blocks the progression of experimental autoimmune encephalomyelitis after the priming of autoimmunity. Clin Immunol. 2011 Dec;141(3):304-16.
  • Mills H, Wragg R, Hapiak V, Castelletto M, Zahratka J, Harris G, Summers P, Korchnak A, Law W, Bamber B, Komuniecki R. 2011 Monoamines and neuropeptides interact to inhibit aversive behaviour in Caenorhabditis elegans. EMBO J. Nov 29;31(3):667-78.
  • Raikhy G, Krause C, Leisner S. (2011) The Dahlia mosaic virus gene VI product N-terminal region is involved in self-association. Virus Res. Jul;159(1):69-72.
  • Rasche S, Phillips, McInerney, M., Sercarz, E and Quinn A. (2011) IL-13-mediated regulation of autoimmunity to GAD65. 2011 Diabetes Jun;60(6):1716-25
  • Rider L, Diakonova M. (2011) Adapter protein SH2B1beta binds filamin A to regulate prolactin dependent cytoskeletal reorganization and cell motility. Mol Endocrinol. Jul;25(7):1231-43.
  • Rosebeck, S., Sudini, K, Chen, T. and Leaman DW. (2011) Involvement of Noxa in mediating cellular ER stress responses to lytic virus infection. Virology. Sep 1;417(2):293-303.
  • Tao J, Oladimeji P, Rider L, Diakonova M. (2011) PAK1-Nck Regulates Cyclin D1 Promoter Activity in Response to Prolactin. Mol Endocrinol. Sep;25(9):1565-78.
  • Tipton AR, Wang K, Link L, Bellizzi JJ, Huang H, Yen T, Liu ST. (2011) BUBR1 and closed MAD2 (C-MAD2) interact directly to assemble a functional mitotic checkpoint complex (MCC). J Biol Chem. 286(24):21173-9.
  • Tipton, A.R., Tipton, M., Yen, T. J., Liu, S.T. (2011)Closed MAD2 (C-MAD2) is selectively incorporated into the mitotic checkpoint complex (MCC). Cell Cycle. 10(21): 3740-50.
  • Zellner W, Frantz J, Leisner S. (2011) Silicon delays Tobacco ringspot virus systemic symptoms in Nicotiana tabacum. J Plant Physiol. Oct 15;168(15):1866-9.
  • Zhan Y, Modi N, Stewart AM, Hieronimus RI, Liu J, Gutmann DH, Chadee DN. (2011) Regulation of mixed lineage kinase 3 is required for Neurofibromatosis-2-mediated growth suppression in human cancer. Oncogene. 30:781-9.


  • Abi Saab, WF., Brown, MS and Chadee, DN. (2012) MLK4b functions as a negative regulator of MAPK signaling and cell invasion. Oncogenesis. 1:1-6.
  • Cai C, Hsieh CL, Gao S, Kannan A, Bhansali M, Govardhan K, Dutta R, Shemshedini L. (2012) Soluble guanylyl cyclase α1 and p53 cytoplasmic sequestration and down-regulation in prostate cancer. Mol Endocrinol. Feb;26(2):292-307.
  • Date, D, Dreier, MR, Borton, MT, Bekier, ME and Taylor, WR. (2012). Effects of Phosphatase and Proteasome Inhibitors on Borealin Phosphorylation and Degradation. Journal of Biochemistry, 151:361-369.
  • Komuniecki R, Harris G, Hapiak V, Wragg R, Bamber B. (2012) Monoamines activate neuropeptide signaling cascades to modulate nociception in C. elegans: a useful model for the modulation of chronic pain? Invert Neurosci. Jun;12(1):53-61.
  • Komuniecki R, Law WJ, Jex A, Geldhof P, Gray J, Bamber B, Gasser RB. (2012) Monoaminergic signaling as a target for anthelmintic drug discovery: receptor conservation among the free-living and parasitic nematodes. Mol Biochem Parasitol. May;183(1):1-7.
  • Lin, L, Tran, T., Hu, S., Cramer, T, Komuniecki, R. and Steven, R. (2012) C. elegans RHGF-2 is an essential RHO-1 specific RhoGEF that binds to the multi-PDZ domain scaffold protein MPZ-1. PLoS ONE 7(2):e31499
  • Liu, Q. and F. Dong. (2012) Gfi-1 inhibits the expression of eosinophil major basic protein (MBP) during G-CSF-induced neutrophilic differentiation. Int J Hematol. 95(6):640.
  • M. A. Siddiqui and K. Malathi.  RNase L Induces Autophagy via c-Jun N-terminal Kinase and Double-stranded RNA-dependent Protein Kinase Signaling Pathways. THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 287, NO. 52, pp. 43651–43664, December 21, 2012.
  • Purohit AA, Li W, Qu C, Dwyer T, Shao Q, Guan KL, Liu G. (2012) Down Syndrome Cell Adhesion Molecule (DSCAM) Associates with Uncoordinated-5C (UNC5C) in Netrin-1-mediated Growth Cone Collapse. J Biol Chem. 2012 Aug 3;287(32):27126-38.
  • Tipton AR, Wang K, Oladimeji P, Sufi S, Gu Z, Liu ST. (2012) Identification of novel mitosis regulators through data mining with human centromere/kinetochore proteins as group queries. BMC Cell Biol. Jun 19;13(1):15.
  • Zhan Y, Abi Saab WF, Modi N, Stewart AM, Liu J, Chadee DN. (2012) Mixed lineage kinase 3 is required for matrix metalloproteinase expression and invasion in ovarian cancer cells. Exp Cell Res. Aug 15;318(14):1641-8.


  • Angel CA1, Lutz L, Yang X, Rodriguez A, Adair A, Zhang Y, Leisner SM, Nelson RS, Schoelz JE. (2013). The P6 protein of Cauliflower mosaic virus interacts with CHUP1, a plant protein which moves chloroplasts on actin microfilaments. Virology. 2013 Sep 1;443(2):363-74. doi: 10.1016/j.virol.2013.05.028. Epub 2013 Jun 12.
  • Avidor-Reiss T. Gopalakrishnan J. Cell Cycle Regulation of the Centrosome and Cilium. Drug Discovery Today: Disease Mechanisms 2013 http://dx.doi.org/10.1016/j.ddmec.2013.03.002
  • Basiri, ML. Blachon S.  Chim, YCF, and Avidor-Reiss T. Imaging Centrosomes in Fly Testes.  The Journal of Visualized Experiments 2013 Sep 20;(79):e50938. doi: 10.3791/50938.
  • Chadee DN. Involvement of mixed lineage kinase 3 in cancer. Can J Physiol Pharmacol. 2013 Apr;91(4):268-74. doi: 10.1139/cjpp-2012-0258. Epub 2012 Dec 19. Review.
  • Du P, Tang F, Qiu Y, Dong F. GFI1 is repressed by p53 and inhibits DNA damage-induced apoptosis. PLoS One. 2013 Sep 4;8(9):e73542. doi: 10.1371/journal.pone.0073542. eCollection 2013.
  • Gao S, Hsieh CL, Bhansali M, Kannan A, Shemshedini L.  A peptide against soluble guanylyl cyclase α1: a new approach to treating prostate cancer. PLoS One. 2013 May 27;8(5):e64189. doi: 10.1371/journal.pone.0064189. Print 2013.
  • Gao S, Hsieh CL, Zhou J, Shemshedini L. Zinc Finger 280B regulates sGCα1 and p53 in prostate cancer cells. PLoS One. 2013 Nov 13;8(11):e78766. doi: 10.1371/journal.pone.0078766. eCollection 2013.
  • Hammer A, Rider L, Oladimeji P, Cook L, Li Q, Mattingly RR, Diakonova M. (2013). Tyrosyl phosphorylated PAK1 regulates breast cancer cell motility in response to prolactin through filamin A. Mol Endocrinol. 2013 Mar;27(3):455-65. doi: 10.1210/me.2012-1291. Epub 2013 Jan 22.
  • Hapiak V, Summers P, Ortega A, Law WJ, Stein A, Komuniecki R. (2013). Neuropeptides amplify and focus the monoaminergic inhibition of nociception in Caenorhabditis elegans. J Neurosci. 2013 Aug 28;33(35):14107-16. doi: 10.1523/JNEUROSCI.1324-13.
  • Hapiak V, Summers P, Ortega A, Law WJ, Stein A, Komuniecki R. Neuropeptides amplify and focus the monoaminergic inhibition of nociception in Caenorhabditis elegans. J Neurosci. 2013 Aug 28;33(35):14107-16. doi: 10.1523/JNEUROSCI.1324-13.2013.
  • Ma, J. , Zhang, L., *Tipton, A.R, Wu, J., Messmer-Blust, A., Philbrick, M., Qi, Y., Liu, S.T., Liu, H., Li, J. and Guo, S. (2013) Structural and Functional Analysis of the Related Transcriptional Enhancer Factor-1 (RTEF-1) and Nuclear Factor Kappa B (NF-κB) Interaction. American Journal of Physiology-Heart and Circulatory Physiology. 2013 Nov 8. [Epub ahead of print]. PMID: 24213609
  • Pei Du, Fangqiang Tang, Yaling Qiu, and Fan Dong*. (2013). GFI1 Is Repressed by p53 and Inhibits DNA Damage-Induced Apoptosis. PLoS One. 2013; 8(9): e73542.
  • Pierce LR1, Willey JC, Crawford EL, Palsule VV, Leaman DW, Faisal M, Kim RK, Shepherd BS, Stanoszek LM, Stepien CA. (2013).  A new StaRT-PCR approach to detect and quantify fish Viral Hemorrhagic Septicemia virus (VHSv): enhanced quality control with internal standards. J Virol Methods. 2013 Apr;189(1):129-42. doi: 10.1016/j.jviromet.2013.01.006. Epub 2013 Jan 30.
  • Qu C, Dwyer T, Shao Q, Yang T, Huang H, and Liu G (2013). Direct Binding of TUBB3 with DCC Couples Netrin-1 Signaling to Intracellular Microtubule Dynamics in Axon Outgrowth and Guidance. Journal of Cell Science 126 (14): 3070-3081. (Selected in In This Issue)            
  • Qu C, Li W, Shao Q, Dwyer T, Huang H, Yang T, and Liu G (2013). c-Jun N-Terminal Kinase 1 (JNK1) Is Required for Coordination of Netrin Signaling in Axon Guidance. Journal of Biological Chemistry 288 (3): 1883–1895.                 
  • Rider L, Oladimeji P, Diakonova M. (2013). PAK1 regulates breast cancer cell invasion through secretion of matrix metalloproteinases in response to prolactin and three-dimensional collagen IV. Mol Endocrinol. 2013 Jul;27(7):1048-64. doi: 10.1210/me.2012-1322. Epub 2013 Jun 6.
  • Rossig C, Reinbothe C, Gray J, Valdes O, von Wettstein D, Reinbothe S. (2014). New functions of the chloroplast Preprotein and Amino acid Transporter (PRAT) family members in protein import. Plant Signal Behav. Jan 29;9(1). pii: e27693. [Epub ahead of print] Review.
  • Tipton AR, Ji W, Sturt-Gillespie B, Bekier ME 2nd, Wang K, Taylor WR, Liu ST. Monopolar spindle 1 (MPS1) kinase promotes production of closed MAD2 (C-MAD2) conformer and assembly of the mitotic checkpoint complex. J Biol Chem. 2013 Dec 6;288(49):35149-58. doi: 10.1074/jbc.M113.522375. Epub 2013 Oct 22.
  • Zhang X, Tao Y, Wang J, Garcia-Mata R, Markovic-Plese S. 2013. Simvastatin inhibits secretion of Th17-polarizing cytokines and antigen presentation by DCs in patients with relapsing remitting MS. Eur J Immunol. 43, 281-289.


  • Blachon S, Khire A, and Avidor-Reiss T.  The Origin of the Second Centriole of the Zygote.  Genetics. Early Online February 13, 2014, doi:10.1534/genetics.113.160523
  • C. Guilluy, L. Osborne, L. Van Landeghem, L. Sharek, R. Superfine, R. Garcia-Mata, and Keith Burridge. 2014. Isolated nuclei adapt to force and reveal a mechanotransduction pathway within the nucleus, Nature Cell Biology (Mar 9. doi: 10.1038/ncb2927. [Epub ahead of print])
  • Liu, S.T. (2014) Kinetochore Strucuture, Function and Evolution (version 2.0), In: Encyclopedia of Life Sciences (ELS).John Wiley & Sons, Ltd. Chichester. invited review.
  • Richard Komuniecki, Vera Hapiak, Ph. D.; Gareth Harris, Ph. D.; Bruce Bamber, Ph. D. (2014) Context-dependent modulation configures interact sensory-mediated microcircuits in C. elegans
  • Rossig C, Reinbothe C, Gray J, Valdes O, von Wettstein D, Reinbothe S. New functions of the chloroplast Preprotein and Amino acid Transporter (PRAT) family members in protein import. Plant Signal Behav. 2014 Jan 29;9(1). pii: e27693. [Epub ahead of print] Review.
  • S.M. Goicoechea , R. Garcia-Mata, J. Staub, A. Valdivia, L. Sharek, C.A. McCulloch, R. Hwang, R. Urrutia, J.J. Yeh, H.J, Kim, and C. Otey. 2014. Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in cancer-associated fibroblasts, Oncogene  (6;33(10):1265-73)
  • S.M. Goicoechea , S. Awadia and R. Garcia-Mata. 2014. I'm coming to GEF you. Regulation of RhoGEFs during cell migration. Cell Adhesion & Migration (in press)
  • RNase L interacts with Filamin A to regulate actin dynamics and barrier function for viral entry. Malathi K*, Siddiqui MA, Dayal S, Naji M, Ezelle HJ, Zeng C, Zhou A, Hassel BA. MBio. 2014 Oct 28;5(6):e02012. doi: 10.1128/mBio.02012-14.PMID:25352621(*Communicating  author).
  • RNase L contributes to experimentally induced type 1 diabetes onset in mice. Zeng C, Yi X, Zipris D, Liu H, Zhang L, Zheng Q, Malathi K, Jin G, Zhou A. J Endocrinol. 2014 Dec;223(3):277-87. doi: 10.1530/JOE-14-0509. Epub 2014 Oct 6. PMID:25287058
  • Epigallocatechin-3-gallate suppresses proinflammatory cytokines and chemokines induced by Toll-like receptor 9 agonists in prostate cancer cells. Mukherjee S, Siddiqui MA, Dayal S, Ayoub YZ, Malathi K*.  J Inflamm Res. Jun 17;7:89-101, 2014. (*Communicating  author).



Last Updated: 8/10/18