Department of Biological Sciences


Biological Sciences Menu



Contact Us

Main Campus
Wolfe Hall

Room 1235
Phone: 419.530.2065
Fax: 419.530.7737

Recent Publications by Faculty of UT Biological Sciences

Department of Biological Sciences Publications 


  • Bamber, B.A., Rowland, A.M. Shaping cellular form and function by autophagy. Autophagy. 2006 Jul-Sep;2(3):247-9.
  • Chadee, D.N., Scoles, D.R., Lim, D.J., Luo, Z., Gutmann, D.H., and Kyriakis, J.M. (2006) MLK3 regulates B-Raf through a mechanism that involves maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein. Proc. Natl. Acad. Sci. U S A. Mar 21;103(12), 4463-8.
  • Chen, S.Y., Cai, C., Fisher, C.J., Zheng, Z., Omwancha, J., Hsieh, C.L. Shemshedini, L. c-Jun enhancement of androgen receptor transactivation is associated with prostate cancer cell proliferation. Oncogene. 2006 Nov 16;25(54):7212-23.
  • Hobson, R.J., Hapiak, V.M., Xiao, H., Buehrer, K.L., Komuniecki, P.R, Komuniecki, R.W. SER-7, a Caenorhabditis elegans 5-HT7-like receptor, is essential for the 5-HT stimulation of pharyngeal pumping and egg laying. Genetics. 2006 Jan;172(1):159-69.
  • Liu, H., Qiu, Y., Xiao, L., Dong, F. Involvement of protein kinase Cepsilon in the negative regulation of Akt activation stimulated by granulocyte colony-stimulating factor. J. Immunol. 2006 Feb 15;176(4):2407-13.
  • Mohammad, M.K., Slotterbeck, B., Morran, M., Leaman, D.W., von Grafenstein, H., Hong, S-C., McInerney, M.F. (2006) Dysregulated Toll Like Receptors in Bone Marrow Derived Macrophages at the Onset of Diabetes in the Nonobese Diabetic Mouse. International Immunology, 18:1101-1113.
  • Molinaro RJ, Jha BK, Malathi K, Varambally S, Chinnaiyan AM, Silverman RH. Selection and cloning of poly(rC)-binding protein 2 and Raf kinase inhibitor protein RNA activators of 2',5'-oligoadenylate synthetase from prostate cancer cells. Nucleic Acids Res. 2006;34(22):6684-95.
  • Olszewski, M.A., Gray, J., Vestal, D.J. In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters. J. Interferon Cytokine Res. 2006 May;26(5):328-52.
  • Omwancha, J., Zhou, X.F., Chen, S.Y., Baslan, T., Fisher. C.J., Zheng, Z., Cai, C., Shemshedini, L. Makorin RING finger protein 1 (MKRN1) has negative and positive effects on RNA polymerase II-dependent transcription. Endocrine. 2006 29(2):363-73.
  • Paranjape, J.M., Xu, D., Kushner, D.M., Okicki, J., Lindner, D. Cramer, H., Silverman, R.H., and Leaman, D.W. (2006) Assessing human telomerase RNA degradation by 2-5A- antisense chimeras in a cell-free system, tumor cells and murine xenografts. Oligonucleotides, 16:225-240.
  • Quinn, A., McInerney, M., Huffman, D., McInerney, B., Mayo, S., Haskins, K., Sercarz, E. T cells to a dominant epitope of GAD65 express a public CDR3 motif. Int. Immunol. 2006 Jun;18(6):967-79.
  • Reu, F.J., Bae, S., Cherkassky, L., Leaman, D.W., Beauliieu, N., Macleod, R., and Borden, E.C. (2006). Overcoming resistance to interferon-induced apoptosis of renal cancer and melanoma cells by DNA demethylation. J. Clin. Oncol., Epub June 2006
  • Rowland, A.M., Richmond, J.E., Olsen, J.G., Hall, D.H., Bamber, B.A. Presynaptic terminals independently regulate synaptic clustering and autophagy of GABAA receptors in Caenorhabditis elegans. J. Neurosci. 2006 Feb 8;26(6):1711-20.
  • Sammons, M., S.S. Wan, N.L. Vogel, E.J. Mientjes, G. Grosveld, and B.P. Ashburner. Negative regulation of the RelA/p65 transactivation function by the product of the DEK proto-oncogene. J. Biol Chem. 2006. 281: 26802-26812.
  • Stark GR, Taylor WR. Control of the G2/M transition. Mol Biotechnol. 2006 32(3):227-48.
  • Taylor, K.L., Oates, R.K., Grane, R., Leaman, D.W., Borden, E.C., Lindner, D.J. (2006) IFN-alpha1,8 Inhibits Tumor-Induced Angiogenesis in Murine Angiosarcomas. J. Interferon Cytokine Res. 26:353-361.
  • Urisman A, Molinaro RJ, Fischer N, Plummer SJ, Casey G, Klein EA, Malathi K, Magi-Galluzzi C, Tubbs RR, Ganem D, Silverman RH, DeRisi JL. Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant. PLoS Pathog. 2006 2(3):e25.
  • Vogel, N.L., M. Boeke, and B.P. Ashburner. SPermidine/Spermine N1-acetyltransferase 2 (SSAT2) functions as a coactivator for NK-kB and cooperates with CBP and P/CAF to enhance NF-kB-dependent transcription. Biochimica et Biophysica Acta: Gene Structure and Expression. 2006. 1759:470-477.
  • Wardell, B., Marik, P.S., Piper, D., Rutar T., Jorgensen, E.M., Bamber, B.A.. Residues in the first transmembrane domain of the Caenorhabditis elegans GABA(A) receptor confer sensitivity to the neurosteroid pregnenolone sulfate. Br. J. Pharmacol. 2006 May;148(2):162-72.
  • Xiao, H., Hapiak, V.M., Smith, K.A., Lin, L., Hobson, R.J., Plenefisch, J., Komuniecki, R. SER-1, a Caenorhabditis elegans 5-HT2-like receptor, and a multi-PDZ domain containing protein (MPZ-1) interact in vulval muscle to facilitate serotonin-stimulated egg-laying. Dev. Biol. 2006 298(2):379-91.
  • Zheng, Z., Cai, C., Omwancha, J., Chen, S.Y., Baslan, T., Shemshedini, L. SUMO-3 enhances androgen receptor transcriptional activity through a sumoylation-independent mechanism in prostate cancer cells. J. Biol. Chem. 2006 Feb 17;281(7):4002-12
  • Zhuang, D., Qiu, Y., Kogan, S.C., Dong, F. J. Increased CCAAT enhancer-binding protein epsilon (C/EBPepsilon) expression and premature apoptosis in myeloid cells expressing Gfi-1 N382S mutant associated with severe congenital neutropenia. Biol. Chem. 2006 281(16):10745-51.


  • Cai, C., Chen, S.Y., Zheng, Z., Omwancha, J., Lin, M.F., Balk, S.P., Shemshedini, L. Androgen regulation of soluble guanylyl cyclase alpha1 mediates prostate cancer cell proliferation. Oncogene. 2007 Mar 8;26(11):1606-15.
  • Cai, C., Hsieh, C.L. Omwancha, J., Zheng, Z., Chen, S.Y., Baert, J.L., Shemshedini, L. ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion. Mol. Endocrinol. 2007 Aug;21(8):1835-46.
  • Cai, C., Hsieh, C.L., Shemshedini, L. c-Jun has multiple enhancing activities in the novel cross talk between the androgen receptor and Ets variant gene 1 in prostate cancer. Mol. Cancer Res. 2007 Jul;5(7):725-35.
  • Cai, C., Omwancha, J., Hsieh, C.L., Shemshedini, L. Androgen induces expression of the multidrug resistance protein gene MRP4 in prostate cancer cells. Prostate Cancer Prostatic Dis. 2007;10(1):39-45.
  • Date DA, Jacob CJ, Bekier ME, Stiff AC, Jackson MW, Taylor WR. Borealin is repressed in response to p53/Rb signaling. Cell Biol Int. 2007 31(12):1470-81.
  • Diakonova, M., Helfer, E., Seveau, S., Swanson, J.A., Kocks, C., Rui, L., Carlier, M.F., Carter-Su, C. Adapter protein SH2-Bbeta stimulates actin-based motility of Listeria monocytogenes in a vasodilator-stimulated phosphoprotein (VASP)-dependent fashion. Infect. Immun. 2007. Jul: 75(7): 3581-93.
  • Dong B, Kim S, Hong S, Das Gupta J, Malathi K, Klein EA, Ganem D, Derisi JL, Chow SA, Silverman RH. An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors. Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1655-60.
  • Ghedin, E., Wang, S., Spiro, D., Caler, E., Zhao, Q., Crabtree, J., Allen, J.E., Delcher, A.L., Guiliano, D.B., Miranda-Saavedra, D., Angiuoli, S.V., Creasy, T., Amedeo, P., Haas, B., El-Sayed, N.M., Wortman, J.R., Feldblyum, T., Tallon, L., Schatz, M., Shumway, M., Koo, H., Salzberg, S.L., Schobel, S., Pertea, M., Pop, M., White, O., Barton, G.J., Carlow, C.K., Crawford, M.J., Daub,J., Dimmic, M.W., Estes, C.F., Foster, J.M., Ganatra, M., Gregory, W.F., Johnson, N.M., Jin, J., Komuniecki, R., et al….. Scott, A.L. Draft genome of the filarial nematode parasite Brugia malayi. Science. 2007 Sep 21;317(5845):1756-60.
  • Huang, H., Feng, J., Famulski, J., Rattner, J.B., Liu, S.T., Kao, G.D., Muschel, R., Chan, G.K., Yen, T.J. Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments. J. Cell Biol. 2007 May 7;177(3):413-24.
  • Kaur H, Stiff AC, Date DA, Taylor WR. Analysis of mitotic phosphorylation of borealin. BMC Cell Biol. 2007 Jan 22;8:5.
  • Liu G, Li W, Gao X, Li X, Jürgensen C, Park HT, Shin NY, Yu J, He ML, Hanks SK, Wu JY, Guan KL, Rao Y. p130CAS is required for netrin signaling and commissural axon guidance. J Neurosci. 2007 27(4):957-68.
  • Malathi K, Dong B, Gale M Jr, Silverman RH. Small self-RNA generated by RNase L amplifies antiviral innate immunity. Nature. 2007 Aug 16;448(7155):816-9.
  • Mayo, S., Quinn, A. Altered susceptibility to EAE in congenic NOD mice: Altered processing of the encephalitogenic MOG35-55 peptide byu NOR/LtJ mice. Clin. Immunol. 2007 Jan;122(1):91-100.
  • Rajakaruna, P., Khandekar, S., Meulia, T., and Leisner, S.M. 2007. Identification and host relations of Turnip ringspot virus, a novel comovirus from Ohio. Plant Disease 91:1212-1220.
  • Reddy, G.R., Pushpanathan, M.J., Ransom, R.F., Holzman, L.B., Brosius, 3rd, F.C., Diakonova, M., Mathieson, P., Saleem, M.A., List, E.O., Kopchick, J.J., Frank, S.J., Menon, R.K. Identification of the glomerular podocyte as a target for growth hormone action. Endocrinology. 2007 148(5):2045-55.
  • Rider, L., Shatrova, A., Feener, E.P., Webb, L. Diakonova, M. JAK2 tyrosine kinase phosphorylates PAK1 and regulates PAK1 activity and functions. J. Biol. Chem. 2007 Oct 19;282(42):30985-96.
  • Sairyo, K., Biyani, A.V., Goel, K., Leaman, D.W., Booth, Jr., R., Thomas, J., Ebraheim, N.A., Cowgill, I.A. and Mohan, S.E. (2007) Lumbar ligamentum flavum hypertrophy is due to accumulation of inflammation related scar tissue. SPINE 32:2805-2811.
  • Smith, K.A., Komuniecki, R.W., Ghedin, E., Spiro, D., Gray, J. Genes encoding putative biogenic amine receptors in the parasitic nematode Brugia malayi. Invert. Neurosci. 2007 Dec;7(4):227-44.
  • Smith, K.A., Rex, E.B., Komuniecki, R.W. Are Caenorhabditis elegans receptors useful targets for drug discovery: pharmacological comparison of tyramine receptors with high identity from C. elegans (TYRA-2) and Brugia malayi (Bm4). Mol. Biochem. Parasitol. 2007 Jul;154(1):52-61.
  • Twede, V., Tartaglia, A.L., Covey, D.F., Bamber, B.A. The neurosteroids dehydroepiandrosterone sulfate and pregnenolone sulfate inhibit the UNC-49 GABA receptor through a common set of residues. Mol. Pharmacol. 2007 Nov;72(5):1322-9.
  • Wragg, R.T., Hapiak ,V., Miller, S.B., Harris, G.P., Gray, J., Komuniecki, P.R., Komuniecki, R.W. Tyramine and octopamine independently inhibit serotonin-stimulated aversive behaviors in Caenorhabditis elegans through two novel amine receptors. J. Neurosci. 2007 Dec 5;27(49):13402-12.
  • Wragg, R.T., Hapiak ,V., Miller, S.B., Harris, G.P., Gray, J., Komuniecki, P.R., Komuniecki, R.W. Tyramine and octopamine independently inhibit serotonin-stimulated aversive behaviors in Caenorhabditis elegans through two novel amine receptors. J. Neurosci. 2007 Dec 5;27(49):13402-12.


  • Bartsch, S., Monnet, J., Selbach, K., Quigley, F., Gray, J., von Wettstein, D., Reinbothe, S., Reinbothe, C. Three thioredoxin targets in the inner envelope membrane of chloroplasts function in protein import and chlorophyll metabolism. Proc. Natl. Acad. Sci. U S A. 2008 105(12):4933-8.
  • Bechtel JM, Rajesh P, Ilikchyan I, Deng Y, Mishra PK, Wang Q, Wu X, Afonin KA, Grose WE, Wang Y, Khuder S, Federov A: The Alternative Splicing Mutation Database: a hub for investigators of alternative splicing using mutational evidence. BMC Research Notes, 2008, 1:3
  • Bechtel JM, Rajesh P, Ilikchyan I, Deng Y, Mishra PK, Wang Q, Wu X, Afonin KA, Grose WE, Wang Y, Khuder S, Federov A: Calculation of Splicing Potential from the Alternative Splicing Mutation Database. BMC Research Notes, 2008, 1:4
  • Dai, Y.D., Jensen, K.P., Marrero, I., Li, N., Quinn, A., Sercarz, E.E. N-terminal flanking residues of a diabetes-associated GAD65 determinant are necessary for activation of antigen-specific T cells in diabetes-resistant mice. Eur. J. Immunol. 2008 Apr;38(4):968-76.
  • Hapiak, M., Li., Y., Agama, K., Swade, S., Okenka, G., Falk, J., Khandekar, S., Raikhy, G., Anderson, A., Pollock, J., Zellner, W., Schoelz, J., and S. M. Leisner. Cauliflower mosaic virus gene VI Product N-Terminus Contains Regions Involved In Resistance-Breakage, Self-Association And Interactions With Movement Protein. Virus Research. 2008. 138: 119-129.
  • Hsieh, C.L., Cai, C., Giwa, A., Bivins, A., Chen, S.Y., Sabry, D., Govardhan, K., Shemshedini, L. Expression of a hyperactive androgen receptor leads to androgen-independent growth of prostate cancer cells. J. Mol. Endocrinol. 2008 Jul;41(1):13-23.
  • Klionsky, D.J., Abeliovich, H., Agostinis, P., Agrawal, D.K., Aliev, G., Askew, D.S., Baba, M., Baehrecke, E.H., Bahr, B.A., Ballabio, A., Bamber, B.A., Bassham, D.C., Bergamini, E., Bi, X., Biard-Piechaczyk, M., Blum, J.S., Bredesen, D.E., Brodsky, J.L., et. al …….., Deter, R.L. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy. 2008 Feb 16;4(2):151-75.
  • Leaman, D.W. (2008) Recent advances in Nucleic Acid Therapeutics. Expert Opinion Drug Discovery. 3:997-1009.
  • Li, J., Frantz, J., and Leisner, S. Alleviation of Copper Toxicity in Arabidopsis thaliana by Silicon Addition to Hydroponic Solutions. Journal of the American Society of Horticultural Science 2008. 133: 1-8.
  • Rosebeck, S.R. and Leaman, D.W. (2008). Mitochondrial localization of the Interferon-inducible protein ISG12a. Apoptosis. 13:562-572.
  • Taylor, K.L., Leaman, D.W., Grane, R., Borden, E.C., Lindner, D.J. (2008) Identification of Interferon-beta-Stimulated Genes That Inhibit Angiogenesis In Vitro. J. Interferon Cytokine Res. 28(12):733-40.


  • Basu, S., Liu, Q., Qiu, Y., Dong, F. Gfi-1 represses CDKN2B encoding p15INK4B through interaction with Miz-1. Proc. Natl. Acad. Sci. U S A. 2009 Feb 3;106(5):1433-8.
  • Cole ET, Zhan Y, Abi Saab WF, Korchnak AC, Ashburner BP, Chadee DN. Mixed lineage kinase 3 negatively regulates IKK activity and enhances etoposide-induced cell death. Biochim Biophys Acta. 2009 1793(12):1811-8.
  • Dreier, M., Grabovich, A., Katusin, J., and Taylor, W.R. (2009) Short- and long-term tumor cell responses to Aurora kinase inhibitors. In Press Experimental Cell Research.
  • Goubau, D., Romieu-Mourez,R., Solis, M., Hernandez, E., Mesplède, T., Lin,R., Leaman, D., Hiscott, J. (2008) Transcriptional re-programming of primary macrophages reveals distinct apoptotic and anti-tumoral functions of IRF-3 and IRF-7. Eur. J. Immunol. 2009 Feb;39(2):527-40.
  • Hagihara K, Zhang EE, Ke YH, Liu G, Liu JJ, Rao Y, Feng GS. Shp2 acts downstream of SDF-1alpha/CXCR4 in guiding granule cell migration during cerebellar development. Dev Biol. 2009 334(1):276-84.
  • Hapiak, V.M., Hobson, R.J., Hughes, L., Smith, K., Harris, G., Condon, C., Komuniecki P., Komuniecki, R.W. Dual excitatory and inhibitory serotonergic inputs modulate egg laying in Caenorhabditis elegans. Genetics. 2009 Jan;181(1):153-63.
  • Harris, G.P., Hapiak, V.M., Wragg, R.T., Miller, S.B., Hughes, L.J., Hobson, R.J., Steven, R., Bamber, B., Komuniecki, R.W. Three distinct amine receptors operating at different levels within the locomotory circuit are each essential for the serotonergic modulation of chemosensation in Caenorhabditis elegans. J. Neurosci. 2009 Feb 4;29(5):1446-56.
  • Khandekar S, He J, Leisner S. Complete nucleotide sequence of the Toledo isolate of turnip ringspot virus. Arch Virol. 2009;154(12):1917-22.
  • Korchnak AC, Zhan Y, Aguilar MT, Chadee DN. Cytokine-induced activation of mixed lineage kinase 3 requires TRAF2 and TRAF6. Cell Signal. 2009 21:1620-5.
  • Kosik, A., Bekier, M.E., Katusin, J.D., Kaur, H., Zhou, X., Diakonova, M., Chadee D.N., and Taylor, W.R. (2009). Investigating the role of Aurora kinases in RAS signaling. J. Cell Biochem. 106(1):33-41.
  • Li, X.*, Gao, X.*, Liu, G.*, Xiong, W., Wu, J. and Rao, Y. Netrin Signal Transduction: Roles of the Guanine Nucleotide Exchange Factor DOCK180 in Attractive Signaling. Nature 2009 Neuroscience 11: 28-35(* co-first author).
  • Liu, G., Li, W., Wang, L., Kar, A., Guan, K-L., Rao, Y. and Wu, J. DSCAM Functions as A Netrin Receptor in Guiding Commissural Axon Pathfinding. PNAS 2009 106: 2951–2956.
  • Periyasamy S, Hinds T Jr, Shemshedini L, Shou W, Sanchez ER. FKBP51 and Cyp40 are positive regulators of androgen-dependent prostate cancer cell growth and the targets of FK506 and cyclosporin A. Oncogene. 2010 29(11):1691-701.
  • Quinn A. Are T-cell responses to GAD65 influential in type 1 diabetes? Diabetes. 2009 58(12):2729-30.
  • Rasche S, Busick RY, Quinn A. GAD65-Specific Cytotoxic T Lymphocytes Mediate Beta-Cell Death and Loss of Function. Rev Diabet Stud. 2009 6(1):43-53.
  • Rider L, Tao J, Snyder S, Brinley B, Lu J, Diakonova M. Adapter protein SH2B1beta cross-links actin filaments and regulates actin cytoskeleton. Mol Endocrinol. 2009 23:1065-76.
  • Shemshedini L. Use of reporter genes to study promoters of the androgen receptor. Methods Mol Biol. 2009. 590:195-207.
  • Vyas, K., Chaudhuri, S., Leaman, D.W., Komar, A.A., Musiyenko, A., Barik, S. and Mazumder, B. Genome-wide polysome profiling reveals an inflammation-responsive post-transcriptional operon in IFN-γ-activated monocytes. 2009 Mol. Cell. Biol. Jan;29(2):458-70
  • Wan X, O'Quinn RP, Pierce HL, Joglekar AP, Gall WE, DeLuca JG, Carroll CW, Liu ST, Yen TJ, McEwen BF, Stukenberg PT, Desai A, Salmon ED. Protein architecture of the human kinetochore microtubule attachment site. Cell. 2009 137:672-84.
  • Yilmaz, A., Nishiyama, Jr., M.Y., Fuentes, B.G., Souza, G.M., Janies, D. Gray, J., Grotewold, E. GRASSIUS: a platform for comparative regulatory genomics across the grasses. Plant Physiol. 2009 Jan;149(1):171-80.
  • Zhang J, Gonit M, Salazar MD, Shatnawi A, Shemshedini L, Trumbly R, Ratnam M. C/EBPalpha redirects androgen receptor signaling through a unique bimodal interaction. Oncogene. 2010 29(5):723-38.
  • Zhang, R., Liu, S.T., Chen, W., Bonner, M., Pehrson, J., Yen, T.J., Adams, P.D. HP1 proteins are essential for a dynamic nuclear response that rescues the function of perturbed heterochromatin in primary human cells. Mol. Cell Biol. 2007 Feb;27(3):949-62.


  • Bamber, B.A. Baker C, Sturt BL, Multiple roles for the first transmembrane domain of GABAA receptor subunits in neurosteroid modulation and spontaneous channel activity. Neurosci Lett. 2010 473(3):242-7.
  • Chadee DN, Kyriakis JM. Activation of SAPK/JNKs in vitro. Methods Mol Biol. 2010;661:59-73.
  • Cheriyath, V., D.W. Leaman and E.C. Borden. (2010) Emerging Roles of FAM14 Family Members (G1P3 /ISG 6-16 and ISG12) in Innate Immunity and Cancer. J. Interferon and Cytokine Res.
  • Davis KM, Sturt BL, Friedmann AJ, Richmond JE, Bessereau JL, Grant BD, Bamber BA. Regulated lysosomal trafficking as a mechanism for regulating GABAA receptor abundance at synapses in Caenorhabditis elegans. Mol Cell Neurosci. 2010 44(4):307-17.
  • Fornalé S., Shi X., Chai, C., Encina A., Irar, S., Capellades M., Fuguet E., Torres J-L., Rovira P., Puigdomènech P., Rigau J., Grotewold E., Gray J., and Caparrós-Ruiz D. ZmMYB31 directly represses maize lignin genes and redirects the phenylpropanoid metabolic flux. The Plant Journal 64, (4), 633–644, 2010
  • Harris G, Mills H, Wragg R, Hapiak V, Castelletto M, Korchnak A, Komuniecki RW. The monoaminergic modulation of sensory-mediated aversive responses in Caenorhabditis elegans requires glutamatergic/peptidergic cotransmission. J Neurosci. 2010 30:7889-99.
  • He J, Gray J, Leisner S. A Pelargonium ARGONAUTE4 gene shows organ-specific expression and differences in RNA and protein levels. J Plant Physiol. 2010 167:319-25.
  • Kaur H, Bekier ME, Taylor WR. Regulation of Borealin by phosphorylation at serine 219. J Cell Biochem. 2010 Dec 1;111(5):1291-8.
  • Kullyev A, Dempsey CM, Miller S, Kuan CJ, Hapiak VM, KomunieckiRW, Griffin CT, Sze JY. (2010) A genetic survey of fluoxetine action on synaptic transmission in Caenorhabditis elegans. Genetics. Nov;186(3):929-41.
  • Linkes S, Fry C, Quinn A. Antigen-Experienced CD4lo T Cells Are Linked to Deficient Contraction of the Immune Response in Autoimmune Diabetes. Autoimmune Dis. 2010 Sep 29;2010:920148.
  • Liu Q, Basu S, Qiu Y, Tang F, Dong F. A role of Miz-1 in Gfi-1-mediated transcriptional repression of CDKN1A. Oncogene. 2010 29(19):2843-52.
  • Malathi K, Saito T, Crochet N, Barton DJ, Gale M Jr, Silverman RH. RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP. RNA. Nov;16(11):2108-19, 2010.
  • Messmer-Blust AF, Balasubramanian S, Gorbacheva VY, Jeyaratnam JA, Vestal DJ. The interferon-gamma-induced murine guanylate-binding protein-2 inhibits rac activation during cell spreading on fibronectin and after platelet-derived growth factor treatment: role for phosphatidylinositol 3-kinase. Mol Biol Cell. 2010 Jul;21(14):2514-28.
  • Vestal, D.J. and Jeyaratnam, J.A. (2010) The Guanylate-Binding Proteins (GBPs): Emerging insights into the biochemical properties and functions of this family of large interferon-induced GTPases. Journal of Interferon and Cytokine Research.
  • Zhan Y and Chadee DN. (2010) Inhibition of Cdc42-mediated activation of MLK3 by the tumor suppressor Merlin. Small GTPases 1:183-186.


  • Balasubramanian S, Fan M, Messmer-Blust AF, Yang CH, Trendel JA, Jeyaratnam JA, Pfeffer LM, Vestal DJ. (2011) The interferon-{gamma}-induced GTPase, mGBP-2, inhibits TNF-{alpha}-induction of matrix metalloproteinase-9 (MMP-9) by inhibiting NF-{kappa}B and Rac. J Biol Chem. 3;286(22):20054-64
  • Balasubramanian S, Messmer-Blust AF, Jeyaratnam JA, Vestal DJ. (2011) Role of GTP Binding, Isoprenylation, and the C-Terminal α-Helices in the Inhibition of Cell Spreading by the Interferon-Induced GTPase, Mouse Guanylate-Binding Protein-2. J Interferon Cytokine Res.
  • Bazeley PS, Nestor Kalinoski AL, Ways JA, Liu ST, Ramdath RS, Matsui SI, Allison DC. (2011) A model for random genetic damage directing selection of diploid or aneuploid tumours. Cell Prolif. Jun;44(3):212-23.
  • Dreier MR, Bekier ME 2nd, Taylor WR. (2011) Regulation of sororin by Cdk1-mediated phosphorylation. J Cell Sci. Sep 1;124(Pt 17):2976-87.
  • Frantz, JM., Khandekar, S. and S. Leisner. (2011) Silicon differentially influences Cu toxicity response in silicon-accumulator and non-accumulator species. J. A, Soc. Hort. Sci. 136:329-338.
  • Harris G, Korchnak A, Summers P, Hapiak V, Law WJ, Stein AM, Komuniecki P, Komuniecki R. (2011) Dissecting the serotonergic food signal stimulating sensory-mediated aversive behavior in C. elegans. PLoS One. 6(7):e21897.
  • Harris G, Korchnak A, Summers P, Hapiak V, Law WJ, Stein AM, Komuniecki P, Komuniecki R. (2011) Dissecting the serotonergic food signal stimulating sensory-mediated aversive behavior in C. elegans. PLoS One. 6(7):e21897.
  • Hu S, Pawson T, Steven RM. (2011) UNC-73/Trio RhoGEF-2 Activity Modulates Caenorhabditis elegans Motility Through Changes in Neurotransmitter Signaling Upstream of the GSA-1/G{alpha}s Pathway. Genetics. Sep;189(1):137-51.
  • Khandekar S, Leisner S. (2011) Soluble silicon modulates expression of Arabidopsis thaliana genes involved in copper stress. J Plant Physiol. 168(7):699-705.
  • Kiraly A, Koffman B, Hacker M, Gunning W, Rasche S, Quinn A. (2011) A novel aza-anthrapyrazole blocks the progression of experimental autoimmune encephalomyelitis after the priming of autoimmunity. Clin Immunol. 2011 Dec;141(3):304-16.
  • Mills H, Wragg R, Hapiak V, Castelletto M, Zahratka J, Harris G, Summers P, Korchnak A, Law W, Bamber B, Komuniecki R. 2011 Monoamines and neuropeptides interact to inhibit aversive behaviour in Caenorhabditis elegans. EMBO J. Nov 29;31(3):667-78.
  • Raikhy G, Krause C, Leisner S. (2011) The Dahlia mosaic virus gene VI product N-terminal region is involved in self-association. Virus Res. Jul;159(1):69-72.
  • Rasche S, Phillips, McInerney, M., Sercarz, E and Quinn A. (2011) IL-13-mediated regulation of autoimmunity to GAD65. 2011 Diabetes Jun;60(6):1716-25
  • Rider L, Diakonova M. (2011) Adapter protein SH2B1beta binds filamin A to regulate prolactin dependent cytoskeletal reorganization and cell motility. Mol Endocrinol. Jul;25(7):1231-43.
  • Rosebeck, S., Sudini, K, Chen, T. and Leaman DW. (2011) Involvement of Noxa in mediating cellular ER stress responses to lytic virus infection. Virology. Sep 1;417(2):293-303.
  • Tao J, Oladimeji P, Rider L, Diakonova M. (2011) PAK1-Nck Regulates Cyclin D1 Promoter Activity in Response to Prolactin. Mol Endocrinol. Sep;25(9):1565-78.
  • Tipton AR, Wang K, Link L, Bellizzi JJ, Huang H, Yen T, Liu ST. (2011) BUBR1 and closed MAD2 (C-MAD2) interact directly to assemble a functional mitotic checkpoint complex (MCC). J Biol Chem. 286(24):21173-9.
  • Tipton, A.R., Tipton, M., Yen, T. J., Liu, S.T. (2011)Closed MAD2 (C-MAD2) is selectively incorporated into the mitotic checkpoint complex (MCC). Cell Cycle. 10(21): 3740-50.
  • Zellner W, Frantz J, Leisner S. (2011) Silicon delays Tobacco ringspot virus systemic symptoms in Nicotiana tabacum. J Plant Physiol. Oct 15;168(15):1866-9.
  • Zhan Y, Modi N, Stewart AM, Hieronimus RI, Liu J, Gutmann DH, Chadee DN. (2011) Regulation of mixed lineage kinase 3 is required for Neurofibromatosis-2-mediated growth suppression in human cancer. Oncogene. 30:781-9.


  • Abi Saab, WF., Brown, MS and Chadee, DN. (2012) MLK4b functions as a negative regulator of MAPK signaling and cell invasion. Oncogenesis. 1:1-6.
  • Cai C, Hsieh CL, Gao S, Kannan A, Bhansali M, Govardhan K, Dutta R, Shemshedini L. (2012) Soluble guanylyl cyclase α1 and p53 cytoplasmic sequestration and down-regulation in prostate cancer. Mol Endocrinol. Feb;26(2):292-307.
  • Date, D, Dreier, MR, Borton, MT, Bekier, ME and Taylor, WR. (2012). Effects of Phosphatase and Proteasome Inhibitors on Borealin Phosphorylation and Degradation. Journal of Biochemistry, 151:361-369.
  • Komuniecki R, Harris G, Hapiak V, Wragg R, Bamber B. (2012) Monoamines activate neuropeptide signaling cascades to modulate nociception in C. elegans: a useful model for the modulation of chronic pain? Invert Neurosci. Jun;12(1):53-61.
  • Komuniecki R, Law WJ, Jex A, Geldhof P, Gray J, Bamber B, Gasser RB. (2012) Monoaminergic signaling as a target for anthelmintic drug discovery: receptor conservation among the free-living and parasitic nematodes. Mol Biochem Parasitol. May;183(1):1-7.
  • Lin, L, Tran, T., Hu, S., Cramer, T, Komuniecki, R. and Steven, R. (2012) C. elegans RHGF-2 is an essential RHO-1 specific RhoGEF that binds to the multi-PDZ domain scaffold protein MPZ-1. PLoS ONE 7(2):e31499
  • Liu, Q. and F. Dong. (2012) Gfi-1 inhibits the expression of eosinophil major basic protein (MBP) during G-CSF-induced neutrophilic differentiation. Int J Hematol. 95(6):640.
  • M. A. Siddiqui and K. Malathi.  RNase L Induces Autophagy via c-Jun N-terminal Kinase and Double-stranded RNA-dependent Protein Kinase Signaling Pathways. THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 287, NO. 52, pp. 43651–43664, December 21, 2012.
  • Purohit AA, Li W, Qu C, Dwyer T, Shao Q, Guan KL, Liu G. (2012) Down Syndrome Cell Adhesion Molecule (DSCAM) Associates with Uncoordinated-5C (UNC5C) in Netrin-1-mediated Growth Cone Collapse. J Biol Chem. 2012 Aug 3;287(32):27126-38.
  • Tipton AR, Wang K, Oladimeji P, Sufi S, Gu Z, Liu ST. (2012) Identification of novel mitosis regulators through data mining with human centromere/kinetochore proteins as group queries. BMC Cell Biol. Jun 19;13(1):15.
  • Zhan Y, Abi Saab WF, Modi N, Stewart AM, Liu J, Chadee DN. (2012) Mixed lineage kinase 3 is required for matrix metalloproteinase expression and invasion in ovarian cancer cells. Exp Cell Res. Aug 15;318(14):1641-8.


Last Updated: 6/9/16