Department of Medicine

Division of Endocrinology


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Health Science Campus
Ruppert Health Center
Room # 0012
Phone: 419.383.3685
Fax: 419.383.6244

Raymond Bourey, M.D., F.A.C.P., F.A.C.P., F.A.A.S.M.

Dr. Raymond BoureyRaymond E. Bourey, MD.  Medical Director of the Regional Center for Sleep Medicine.






Faculty Appointment:
Assistant Professor of Medicine

B.A., Biology, 1978, Carleton College
Research Student, 1978-1979 Memorial Sloan-Kettering Cancer Center
M.D. 1982, Southern Illinois University School of Medicine
Internship in Surgery Medicine, 1982-1983, The Miriam Hospital/Brown University School of Medicine
Residency in Internal Medicine 1983-1986, Southern Illinois University School of Medicine
Fellowship in Applied Physiology, 1986-1988, Washington University School of Medicine
Fellowship in Metabolism, 1988-1990, Washington University School of Medicine

Specialty Board Certification:
Internal Medicine, 1986
Endocrinology, Diabetes, and Metabolism, 1991
Sports Medicine, 1999
Sleep Medicine, 2003 and 2007

Instructor of Medicine, Washington University School of Medicine, 1990-1992
Assistant Professor of Medicine, Washington University School of Medicine, 1992-1994
Clinical Assistant Professor of Medicine, Medical College of Ohio, 1994-2007
Director of Diabetes Education, St. Vincent Medical Center, Toledo, 1994-2000
Assistant Professor of Medicine, University of Toledo, 2007

 Research Interests:

  • Neuroendocrine control of appetite, sleep, and metabolism.
  • Menopausal insomnia and obesity, insulin resistance and metabolic syndrome.
  • Genomic and non-genomic mechanisms of estrogen deficiency as a cause of obesity, insulin resistance, and metabolic syndrome.


Dr. Bourey received his M.D. degree in 1982, undertook internship in surgery and medicine at The Miriam Hospital and Brown University and did his residency in Internal Medicine at Southern Illinois University School of Medicine. He did fellowships in both Applied Physiology and in Metabolism in Washington University School of Medicine, where he subsequently served as Assistant Professor of Medicine until he moved to Toledo in 1994.

After early contributions to understanding of exercise, muscle glucose metabolism and aging, Dr. Bourey has turned to focus on neuroendocrine control of appetite, sleep, and metabolism.

Dr. Bourey identified a connection between poor sleep and high morning blood sugars in diabetics. He subsequently undertook additional training and study in sleep medicine, which he felt, as an endocrinologist and exercise physiologist, represented a "back door” to study of metabolic control by brain and central nervous system.

Dr. Bourey’s clinical research currently centers on deleterious effects of menopause on sleep and metabolism. Menopause can be surgical, medication-induced (chemotherapy), or a natural consequence of aging. Menopause is associated with disruption of sleep and features of the metabolic syndrome, including obesity, hypertension, hyperlipidemia, and insulin resistance. Evidence supports a direct metabolic relationship between sleep disruption and development of the metabolic syndrome. Clinical studies are in progress to assess the (1) relationship between sleep disruption as measured by EEG spectral analysis or cyclic alternating pattern of arousal (CAP) and nocturnal hyperglycemia as measured by continuous interstitial fluid glucose monitoring, (2) relationship of sleep disruption to hot flashes or vasomotor events measured by skin conductance, and (3) treatment of menopausal sleep disruption by modulators of voltage-gated calcium channels and other pharmacological interventions.

Dr. Bourey’s laboratory research focuses on two related areas. Mice with fragmented sleep develop abdominal obesity, insulin resistance and other features of the metabolic syndrome. Work is in progress to evaluate related changes in intermediary liver metabolism. Rodents with insufficient estrogen action through estrogen receptor α (ERα) also develop obesity, insulin resistance, and abnormal insulin secretory response. ERα is found in brain areas related to sleep, appetite, and locomotion, as well as organs of insulin action including pancreas, liver, fat, and muscle. In collaboration with other members of CeDER, progress is being made toward elucidation of non-genomic and genomic mechanisms for increased appetite, decreased metabolic rate, insulin resistance, abnormal insulin secretion, and obesity caused by estrogen withdrawal or insufficiency.

Dr. Bourey had published more than 30 peer-reviewed articles, book chapters, and reviews. He has only returned recently to academic medicine, but his research direction is fundamental to the growth of translational research in this institution.


Representative Publications:

Last Updated: 6/9/16