The University of Toledo

Faculty - L. John Greenfield Jr., M.D., Ph.D.

Associate Professor of Neurology Joint Appointment, Department of Pharmacology & Therapeutics email: john.greenfield@utoledo.edu CLINICAL INTERESTS Adult Epilepsy Novel Antiepileptic Drugs Epilepsy Surgery EEG BASIC SCIENCE INTERESTS  Mechanisms of action of Antiepileptic Drugs Structure and function of GABA-A receptors Regulation of GABA-A receptors by chronic     antiepileptic drugs Regulation of voltage-gated sodium channels Human-derived NT2-N cultured neuron

EDUCATION

M.D.:
University of Virginia, Charlottesville, VA, 1989

PH.D:
Neuroscience, University of Virginia, Charlottesville, VA, 1988

Medicine Residency:
Department of Internal Medicine, University of Michigan Hospitals, Ann Arbor, MI, 1989-90

Neurology Residency:
Department of Neurology, University of Michigan Hospitals, Ann Arbor, MI, 1990-93

Fellowship:
Epilepsy and Clinical Neurophysiology, Department of Neurology, University of Michigan Hospitals, Ann Arbor, MI, 1997-98

PROFESSIONAL APPOINTMENTS

Assistant Professor, Dept. of Neurology, University of Michigan, Ann Arbor, MI 1993-1999

Assistant Professor of Neurology and Pharmacology, Medical University of Ohio, Toledo, OH 1999 - present

CERTIFICATIONS

American Board of Psychiatry and Neurology, 1995

SOCIETY MEMBERSHIPS

American Academy of Neurology
American Association for the Advancement of Science
American Epilepsy Society
Society for Neuroscience

EDITORIAL BOARDS

Ad-Hoc Reviewer for:
Neuropharmacology (1994-present)
Epilepsy Research (1994-present)

REPRESENTATIVE PUBLICATIONS

Kume A, Greenfield LJJ, Macdonald RL, Albin RL: Felbamate inhibits [3H]t-butylbicycloorthobenzoate binding and enhances Cl- current at the gamma-aminobutyric acidA receptor. J Pharmacol Exp Therap 1996; 277(3):1-9.

Greenfield LJJ, Macdonald RL: Whole cell and single channel alpha1 beta1 gamma2S GABA A receptor currents elicited by a "multipuffer" drug application device. Pfluger's Archiv 1996; 432:1080-1090.

Greenfield LJJ, Sun F, Neelands TR, Burgard EC, Donnelly JL, Macdonald RL: Expression of functional GABAA receptors in transfected L929 cells isolated by immunomagnetic bead separation. Neuropharmacol 1997; 36(1):63-73.

Neelands TR, Greenfield LJJ, Zhang J, Turner RS, Macdonald RL: GABA-A receptor pharmacology and subtype mRNA expression in human neuronal NT2-N cells. J Neurosci 1998; 18(13):4993-5007.

Greenfield LJJ, Blaivas M, Drury I: De novo status epilepticus due to multiple cerebral hamartomas. Neurology 1999 53:53-54.

Macdonald RL, Greenfield LJJ: Mechanisms of action of new antiepileptic drugs. Curr Opin Neurol 1997; 10 (2):121-128.

Greenfield LJJ: Basic Neurophysiology. In: Labanowski M, ed, Neurology Pearls of Wisdom. Boston, MA: Boston Medical Publishing 1998, pp 10-20.

Greenfield LJJ: Slow Codes (Letter). New Engl J Med 1998; 333(26):1921-22.

Greenfield LJJ: New drugs and therapies for epilepsy. Torchlight 2000, submitted.