Department of Biological Sciences


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Phone: 419.530.2065
Fax: 419.530.7737

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Congratulations to our academic advisor, Amanda Seabolt! She received the Outstanding Advisor award last week.




Researchers take cross-disciplinary look at addressing side effect of cancer treatment

UT researcher receives three NIH grants to study how cancer spreads

Recent Publications

2016 Publications

Naomi Courtemanche*, Thomas Pollard and Qian Chen. (2016) Avoiding artefacts when counting polymerized actin in live cells with LifeAct fused to fluorescent proteins. *, Equal contribution. Nature Cell Biology, 18(6):676-83.

Crawley S.W., Weck M.L., Grega-Larson N.E., Shifrin, D.A., Tyska M.J. (2016) ANKS4B is essential for intermicrovillar adhesion complex formation. Dev Cell. 36(2), 190-200.

Oladimeji P., R. Skerl, C. Rusch and M. Diakonova. The role of tyrosyl phosphorylated PAK1 in the synergetic effect of estrogen and prolactin in breast cancer cells. Cancer Research 2016, 76(9): 2600-11.  doi: 10.1158/0008-5472.CAN-15-1758. PMID: 26944939 

Oladimeji P and Diakonova M. PAK1 translocates into nucleus in response to prolactin but not to estrogen.<> Biochem Biophys Res Commun. 473 (1): 206-11, 2016. doi: 10.1016/j.bbrc.2016.03.079. PMID: 27003261.NIHMS 772746.

Hammer A. and M. Diakonova. Prolactin-induced PAK1 tyrosyl phosphorylation promotes FAK dephosphorylation, breast cancer cell motility, invasion and metastasis. BMC Cell Biology, 17(1):31, 2016. doi: 10.1186/s12860-016-0109-5

Schoelz, J.E., Angel, C.A., Nelson, R.S., Leisner, S.M. (2016). A model for intracellular movement of Cauliflower mosaic virus: the concept of the mobile virion factory. Journal of Experimental Botany 67: 203

Liu, S.T. and Zhang, H. (2016) The mitotic checkpoint complex (MCC): looking back and forth after 15 years.  AIMS Molecular Science, 3(4): 597-634. Review for a special issue on Cell Signaling and Signal Transduction. doi: 10.3934/molsci.2016.4.597

Ji, W., Arnst, C.A., Tipton, A.R., Bekier, M.E. 2nd, Taylor, W. R., Yen, T.J. and Liu, S.T. (2016) OTSSP167 abrogates mitotic checkpoint through inhibiting multiple mitotic kinases. PLOS ONE. PMID: 27082996.

Fedorka, SR, So, K, Gad, I, Shah, R, Junk, D, Rogers, T, Kholodovych, V, Jackson, MW, Taylor, WR and Tillekeratne, LMV. (2016). Small-Molecule Ferroptotic Agents with Potential to Selectively Target Cancer Stem Cells. In preparation

Rajanayake, KK, Taylor, WR, and Dragan Isailovic. (2016). The comparison of glycosphingolipids isolated from an epithelial ovarian cancer cell line and a nontumorigenic epithelial ovarian cell line using MALDI-MS and MALDI-MS/MS. Carbohydrate Research. In press

Bekier ME and Taylor WR. (2016). Traveling through mitosis with the chromosomal passenger complex. In Bradshaw and Stahl (eds). Encyclopedia of Cell Biology. Burlington, MA: Elsevier (BOOK CHAPTER).

Ji, W, Arnst, C, Tipton, AR, Bekier, ME, Taylor, WR, Yen, TJ, Liu,ST. (2016). OTSSP167 abrogates mitotic checkpoint through inhibiting multiple mitotic kinases. PLoS One. 2016 Apr 15;11(4): e0153518. doi: 10.1371/journal.pone.0153518.

2015 Publications

Khire A, Vizuet AA, Davila E, Avidor-Reiss T. Asterless Reduction during Spermiogenesis Is Regulated by Plk4 and Is Essential for Zygote Development in Drosophila. Curr Biol. 2015 Nov 16;25(22):2956-63. doi: 10.1016/j.cub.2015.09.045. Epub 2015 Oct 17. PMID: 26480844

Avidor-Reiss T, Leroux MR. Shared and Distinct Mechanisms of Compartmentalized and Cytosolic Ciliogenesis. Curr Biol. 2015 Dec 7;25(23):R1143-50. doi: 10.1016/j.cub.2015.11.001.

Ha, A., Polyanovsky, A., and Avidor-Reiss, T. Drosophila Hook-Related Protein (Girdin) is Essential for Sensory Dendrite Formation. Genetics. 2015 Jun 9. pii: genetics.115.178954.

Avidor-Reiss T, Khire A, Fishman EL, Jo KH. Atypical centrioles during sexual reproduction. Front Cell Dev Biol. 2015 Apr 1;3:21. doi: 10.3389/fcell.2015.00021. eCollection 2015. Review

Multiple Sensory Inputs Are Extensively Integrated to Modulate Nociception in C. elegans. Summers PJ, Layne RM, Ortega AC, Harris GP, Bamber BA, Komuniecki RW. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2015; 35(28):10331-42. PubMed [journal]PMID: 26180208 PMCID: PMC4502269

Serotonin differentially modulates Ca2+ transients and depolarization in a C. elegans nociceptor. Zahratka JA, Williams PD, Summers PJ, Komuniecki RW, Bamber BA. Journal of neurophysiology. 2015; 113(4):1041-50. PubMed [journal]PMID: 25411461 PMCID: PMC4329441

Goh, Q., Dearth, C.L., Corbett, J.T., Pierre, P., Chadee, D.N., Pizza, F.X. (2015) Intercellular adhesion molecule-1 expression by skeletal muscle cells augments myogenesis. Exp Cell Res., Feb 15;331(2):292-308.

Qian Chen, Naomi Courtemanche and Thomas Pollard. (2015) Aip1 promotes actin filament severing by cofilin and regulates the constriction of the cytokinetic contractile ring. Journal of Biological Chemistry, 290(4):2289-300.

Conti HR, Whibley N, Coleman BM, Garg AV, Jaycox J, Gaffen SL, Signaling through the IL-17C/IL-17RE axis is dispensable for immunity to systemic, oral and cutaneous candidiasis. PLoS One 2015 Apr 7;10(4).

Garg AV, Chen K, Cruz JA, Whibley N, Conti HR, Hernandez Mir G, Amatya N, Sirakova T, Childs EC, Biswas PS, Kolls JK, McGeachy MJ, Kolattukudy PE, Gaffen SL. MCPIP1/Regnase-1 is a negative feedback inhibitor of IL-17-mediated signaling and inflammation. Immunity, 2015 Sep 15;43(3):475-87.

Huppler AR, Verma AH, Conti HR, Gaffen SL, Neutrophils do not express IL-17A in the context of acute oropharyngeal candidiasis. Infection and Immunity 2015 Jul 24;4(3)559-72

Simpson-Abelson MR, Childs EE, Ferreira MC, Bishu S, Conti HR, Gaffen SL, C/EBPβ promotes immunity to oral candidiasis through regulation of β-defensins. PLoS One 2015 Aug 28;10(8)

 Jay J., Hammer A., Nestor-Kalinoski A. and M. Diakonova. JAK2 tyrosin kinase phosphorylates and is negatively regulated by centrosomal protein ninein. Mol Cell Biol. 2015 Jan; 35(1):111-31. doi: 10.1128/MCB.01138-14. PMID: 25332239.

Hammer A., Oladimeji P., De Las Casas L. E. and M. Diakonova. Phosphorylation of Tyrosine 285 of PAK1 facilitates βPIX/ GIT1 binding and regulates adhesion turnover. FASEB J. 2015 Mar; 29(3):943-59. doi: 10.1096/fj.14-259366. PMID:25466889.

Hammer A. and Diakonova M. Tyrosyl Phosphorylated Serine-Threonine Kinase PAK1 is a Novel Regulator of Prolactin-Dependent Breast Cancer Cell Motility and Invasion. In: “Recent Advances in Prolactin Research”, Springer, Switzerland. Editor: M. Diakonova, 2015; doi: 10.1007/978-3-319-12114-7_5. PMID: 25472536.

Hammer A.*, Laghate S* and Diakonova MSrc tyrosyl phosphorylates cortactin in response to prolactin. Biochem Biophys Res Commun. 2015, 463(4): 644-649. doi: 10.1016/j.bbrc.2015.05.116. PMID: 26043691. PMCID: PMC4497854

Oladimeji P., Kubohara Y., Kikuchi H., Oshima Y., Rusch C., Skerl R. and Diakonova M. A Derivative of Differentiation-inducing Factor-3 Inhibits PAK1 Activity and Breast Cancer Cell Proliferation. International Journal of Cancer and Clinical Research, 2015, 2:3.  NIHMSID: NIHMS726981

Hu N, Qiu Y, Dong F. Role of Erk1/2 signaling in the regulation of neutrophil versus monocyte development in response to G-CSF and M-CSF. J Biol Chem. 290:2456, 2015.

RNase L cleavage products promote switch from autophagy to apoptosis by caspase-mediated cleavage of Beclin-1. Siddiqui, MA, Mukherhee, S, Manivannan, P and Malathi K Int. J. Mol. Sci. 2015, 16, 17611-17636; doi:10.3390/ijms160817611.

Lutz, L., Okenka, G., Schoelz, J., and Leisner, S.M. (2015). Mutations within a 35 amino acid region of P6 influence, self-association, inclusion body formation and Caulimovirus infectivity. Virology, 476: 26-36.

Huang H, Shao Q, Qu C, Yang T, Dwyer T, and Liu G (2015). Coordination Interaction of Down Syndrome Cell Adhesion Molecule and Deleted in Colorectal Cancer with Dynamic TUBB3 Mediates Netrin-1-Induced Axon Branching. Neuroscience 293: 109-122.

Bhansali M, Zhou J, Shemshedini L. TM4SF3 and AR: A Nuclear Complex that Stabilizes Both Proteins. Mol Endocrinol. 2016 Jan;30(1):13-25. doi: 10.1210/me.2015-1075. Epub 2015 Dec 9

Borton, ME, Rashid, MS, Dreier, MR, and Taylor, WR.  (2015). Multiple Levels of Regulation of Sororin by Cdk1 and Aurora B. J Cell Biochem. 2015 Jul 14. doi: 10.1002/jcb.25277. 

Bekier, ME, Mazur, T, Rashid, MS and Taylor, WR. (2015).  Borealin dimerization mediates optimal CPC checkpoint function by enhancing localization to centromeres and kinetochores. Nat. Commun. 6:6775 doi: 10.1038/ncomms7775.

Past Publications from the Department of Biological Sciences

Current Grants

R01 R01GM098394  Avidor-Reiss (02/01/2012–01/31/2017) The Mechanism of Pericentriolar Material Assembly During Centrosome Biogenesis. The major goal of this project is to study the mechanism of pericentriolar material assembly during centrosome biogenesis in Drosophila melanogaster.

R01 GM098394-S2 Avidor-Reiss (06/01/2016-01/31/2017) Research Supplements to Promote Diversity in Health-Related Research 

Ohio Third Frontier Technology Validation Startup Fund Bamber (2017-2018) New Anthelmintic Drugs for Veterinary Medicine

NSF I-Corps Bamber (2016-2017) Wormbusters: Improving Agricultural Yields

NIH R15 Chadee (09/09/16-08/31/19) Regulation of MLK3 by oxidative stress in colon cancer cells

NIH R01 DK88127 Diakonova Role of JAK2-PAK1 interaction in prolactin-depending signaling

AHA SDG 15SDG25700054 Du (2015 – 2018) Acid sensing ion channel 1a contributes to synaptic transmission and plasticity in ischemia.

1R21CA194776-01A1, NIH/NCI Garcia-Mata (05/12/2016-03/31/2018) "RhoG Signaling in Invadopodia"

1R15 CA199101-01A1 NIH/NCI Garcia-Mata (05/01/2016-03/31/2019) “Regulation of Invadopodia formation by RhoG specific GEFs and GAPs"

1R03CA197227-01A1 NIH/NCI Garcia-Mata (07/01/2016-6/30/2018) "A Novel RhoG Protein Interaction Network in Invadopodia"

National Institutes of Health, NIAID, R15 Krishnamurthy (02/2016- 01/2019) Novel role of RNA signaling in cross-talk between autophagy and apoptosis. 

NIH/NICHD R15 HD-080512-01 Lui, G. Microtubule Dynamics in Axon Outgrowth and Guidance.

NCI R01CA169500 Lui, S. (5/1/2014-4/30/2018) TRIP13 AAA-ATPase overexpression in chromosomal instability and breast cancer

Administration Supplement to R01CA169500, “Research Supplement to Promote Re-Entry into Biomedical and Behavioral Research Careers” Lui, S. (5/1/2016-4/30/2018) (PA-15-321), funding Dr. Michael Moenk’s career development in the lab

University of Toledo Biomedical Research Innovation Grant Shemshedini

Grant Awards in the Department of Biological Sciences


Last Updated: 4/26/18