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Room: BO 2022
Mail Stop: 602
Dept. Chair: Dr. Jon Kirchhoff
Office: BO 2098 A/B
Phone: (419) 530-7880
Fax: (419) 530-4033
B.S.: University of Sri Jayewardenepura, Sri Lanka
PhD.: Michigan State University, East Lansing, Michigan, USA
Postdoctoral: Washington University School of Medicine, St. Louis, Missouri, USA
Our Research Program
Our recent review article Titled " Subcellular optogenetics: controlling signaling and single cell behavior" is published in JOURNAL OF CELL SCIENCES. Click here to read the article.
Our recent findings are published in the journal NEURON on cross talks between Serotonin (5HT)- gastrin releasing peptide (GRP) receptors and subsequent effects on itch sensation. This new is on NBC news national coverage.
We offer a science outreach program for high school students to conduct research in life sciences!
Quantitative visualization of signaling in living cells surpasses cell disruptive approaches by providing spatio-temporal information about molecular entities that govern complex cellular processes. However there is a lack of approaches that govern signaling in a cell with precise spatial and temporal control to complement the existing assortment of live cell imaging methodologies.
HeLa cell in the movie expresses G protein coupled vision receptors (Opsins) from the retina of the eye. Cell also expresses mCherry tagged gamma-9 subunit. On GPCR activation, G protein beta-gamma subunits translocate to the internal membranes. In this experiment, opsins in the left side of the cell are exposed to a confined blue light pulse (red box). Please note the disappearance of mCherry-gamma-9 from the exposed plasma membrane region immediately after the pulse and appearance in the adjacent ER. Opsin activation is transient and therefore, mCherry-gamma-9 returned to the plasma membrane towards the end of the movie. This shows that opsin can be used to spatially and temporally control signaling in subcellular regions in a cell(Subcelluar optogenetics). Plot shows the dynamics of mCherry-gamma9 in adjacent internal membranes. Karunarathne et al, 2013, PNAS – E1565-E1574