The University of Toledo

Publications

The University of Toledo

33.   Sarkar, S.; Sayler, A. C. D.; Wall, K. A.; Sucheck, S. J. Synthesis and immunological evaluation of a MUC1 glycopeptide incorporated into L-rhamnose displaying liposomes. Bioconjugate. Chem. Submitted.

32.   Ibrahim, D. A.; Boucau, J.; Lajiness, D. H.; Veleti, S. K.; Trabbic, K. R.; Adams, S. S.     Ronning, D. R.; Sucheck S. J. Design, synthesis and X-ray analysis of a glycoconjugate bound to Mycobacterium tuberculosis Antigen 85C. Bioconjugate Chem. 2012, 23, 2403–2416.

31.   Gaitonde, V. and Sucheck S. J. Synthesis of β-Glycosyl amides from N-glycosyl dinitrobenzenesulfonamides J. Carbohydr. Chem. 2012, 31, 433–450.

30.   Karmakar, P.; Talan, S. R.; Sucheck, S. J. Mixed-phase synthesis of glycopeptides using a N-peptidyl-2,4-dinitrobenzenesulfonamide-thioacid ligation strategy. Org. Lett. 2011 Org. Lett. 2011, 13, 5298–5301.

29.   Sarkar, S.; Sucheck S. J. Comparing the use of 2-methylenenapthyl, 4-methoxybenzyl, 3,4-dimethoxybenzyl, and 2,4,6-trimethoxybenzyl as N-H protecting groups for p-tolyl 3,4,6-O-triacetyl-2-acetamido-2-deoxy-1-thio-b-D-glucosides. Carbohydr. Res. 2011, 346, 393-400.

 28.   Sarkar, S.; Lombardo, S. A.; Herner, D. N.; Talan, R. S.; Wall, K. A.; Sucheck S. J. Synthesis of a single molecule L-rhamnose-containing three component vaccine and evaluation of antigenicity in the presence of anti L-rhamnose antibodies. J. Am. Chem. Soc. 2010, 132, 17236-17246.

 27.   Umesiri, F. E.; Sanki, A. K.; Boucau, J.; Ronning, D. R.; Sucheck, S. J. Recent advances towards the inhibition of mAG and LAM synthesis in Mycobacterium tuberculosis. Med. Res. Rev. 2010, 30, 290–326.

 26.   Talan, R. S.; Sanki, A. K.; Sucheck, S. J. Facile synthesis of N-glycosyl amides using a N-glycosyl-2,4-dinitrobenzenesulfonamide and thioacids. Carbohydr. Res. 2009, 344, 2048–2050.

 25.   Sanki, A. K.; Boucau, J.; Umesiri, F. E.; Ronning, D. R.; Sucheck, S. J. Design, synthesis and biological evaluation of sugar-derived esters, a-ketoesters and a-ketoamides as inhibitors for Mycobacterium tuberculosis antigen 85C. Mol. BioSyst. 2009, 5, 945–956.

 24.   Ragupathi, G.; Damani, P.; Srivastava, G.; Srivastava, O.; Sucheck, S. J.; Ichikawa, Y.; Livingston, P. O. Synthesis of sialyl Lewis^a (sLe^a, CA19-9) and construction of an immunogenic sLe^a vaccine. Cancer Immunol. Immunother. 2009, 58, 1397–1405.

 23.   Sanki, A. K.; Talan, R. S.; Sucheck, S. J. Synthesis of small glycopeptides by decarboxylative condensation and insight into the reaction mechanism. J. Org. Chem. 2009, 74, 1886–1896.

 22.   Sanki, A. K.; Boucau, J.; Ronning, D. R.; Sucheck, S. J. Antigen 85C-mediated acyl-transfer between synthetic acyl donors and fragments of the arabinan. Glycoconjugate J. 2009, 26, 589–596.

 21.    Boucau J.; Sanki, A. K.; Voss, B. J.; Sucheck, S. J.; Ronning D. R. A coupled assay measuring Mycobacterium tuberculosis antigen 85C enzymatic activity. Anal. Biochem. 2009, 385, 120–127.

 20.    Sanki A. K.; Boucau J.; Srivastava P.; Adams S. S.; Ronning, D. R., Sucheck, S. J Synthesis of methyl 5-S-alkyl-5-thio-arabinofuranosides and evaluation of their antimycobacterial activity. Bioorg. Med. Chem. 2008, 16, 5672–5682.

 19.    Demaray, J. A.; Thuener, J. E.; Dawson, M. N.; Sucheck, S. J. Synthesis of triazole-oxazolidinones via a one-pot reaction and evaluation of their antimicrobial activity. Bioorg. Med. Chem. Lett. 2008, 18, 4868–4871.

 Optimer Pharmaceuticals, Inc.

 18.   Liang, C.-H; Romero, A.; Rabuka, D.; Sgarbi, P. W. M.; Marby, K. A.; Duffield, J.; Yao, S.; Cheng, M. L; Ichikawa, Y.; Sears, P.; Hu, C.; Hwang, S.-B.; Shue, Y.-K.; Sucheck, S. J. Structure–activity relationships of bivalent aminoglycosides and evaluation of their microbiological activities. Bioorg. Med. Chem. Lett. 2005, 15, 2123–2128.

 17.    Romero, A.; Liang, C.-H.; Chiu, Y.-H.; Yao, S.; Duffield, J.; Sucheck, S. J.; Marby, K.; Rabuka, D.; Leung, P. Y.; Shue, Y.-K.; Ichikawa, Y.; Hwang, C. -K. An efficient entry to new sugar modified ketolide antibiotics. Tet. Lett. 2005, 46, 1483–1487.

 16.    Yao, S.; Sgarbi, P. W. M.; Marby, K. A.; Rabuka, D.; O’Hare, S. M.; Cheng, M. L.; Bairi, M.; Hu, C.; Hwang, S.-B.; Hwang, C.-K.; Ichikawa, Y.; Sears, P.; Sucheck, S. J. Glyco-optimization of aminoglycosides: new aminoglycosides as novel anti-infective agents. Bioorg. Med. Chem. Lett. 2004, 14, 3733–3738.

 15.   Lee L.V., Bower K.E., Liang F.S., Shi J., Wu D., Sucheck S. J., Vogt P.K., Wong C.-H. Inhibition of the proteolytic activity of anthrax lethal factor by aminoglycosides. J. Am. Chem. Soc. 2004; 126, 4774–4775.

14.  Agnelli, F.; Sucheck, S. J.; Marby, K. A; Rabuka, D.; S.-L., Yao; Sears, P. S.; Liang, F.-S.; Wong, C.-H. Dimeric aminoglycosides as antibiotics. Angew. Chem. Int. Ed. 2004, 43, 1562–1566.

 13.  Sucheck, S. J. and Shue, Y.-K. Combinatorial synthesis of aminoglycoside libraries. Curr. Opin. Drug Discovery and Development 2001, 4, 462–470.

 Postdoctoral

 12.  Sucheck, S. J.; Wong, C.-H. RNA as a target for small molecules. Curr. Opin. Chem. Biol. 2000, 4, 678–686.

 11.  Sucheck, S. J.; Wong, A. L.; Koeller, K. M.; Boehr, D. D.; Draker, K.-A.; Sears, P.; Wright, G. D.; Wong, C.-H. Design of bifunctional antibiotics that target bacterial rRNA and inhibit resistance-causing enzymes. J. Am. Chem. Soc. 2000, 122, 5230–5231.

 10.  Sucheck, S. J.; Greenberg, W. A.; Tolbert, T., Wong, C.-H. Design of small molecules that recognize RNA: Development of aminoglycosides as potential antitumor agents that target oncogenic RNA sequences. Angew. Chem., Int. Ed. 2000, 39, 1080–1084.

 Graduate

 9.    Cagir, A.; Tao, Z.-F.; Sucheck, S. J.; Hecht, S. M. Solid phase synthesis and biochemical evaluation of conformationally constrained analogues of deglycobleomycin A₅ Bioorganic Med. Chem. Lett. 2003, 11, 5179–5187.

8.    Sucheck, S. J. Study of naturally occurring nucleic acid interactive agents. 1998, 205 pp.

 7.    Chen, J.; Zhang, Y.-H., Wang, L.-K.; Sucheck, S. J.; Snow, A. M.; Hecht, S. M. Inhibitors of DNA polymerase b from Schoepfia Californica. Chem. Commun. 1998, 2769–2770.

 6.    Katono, K.; An, H.; Aoyagi, Y. Overhand, M.; Sucheck, S. J.; Stevens, W. C. Jr.; Hess, C. D.; Zhou, X.; Hecht, S. M. Total synthesis of bleomycin group antibiotics. The total synthesis of bleomycin demethyl A₂, bleomycin A₂ and decarbamoyl bleomycin demethyl A₂. J. Am. Chem. Soc. 1998, 120, 11285–11296.

 5.    Sucheck, S. J.; Ellena, J. F.; Hecht, S. M. Characterization of Zn(II).deglycobleomycin A₂ and interaction with d(CGCATGCG)₂. Direct evidence for minor groove binding of the bithiazole moiety. J. Am. Chem. Soc. 1998, 120, 7450–7460.

Undergraduate

 4.    Skrzypczak-Jankun, E., Sucheck, S., Smith, D.A. 4-Methyl-3,5-dioxopiperazine acetic acid and 4-methyl-3,5-dioxopiperazine-N-methylacetic amide. Cambridge Crystallographic Data Centre, deposition no. CCDC 118966/CCDC 118967, 1999.

 3.    Smith, D. A., Sucheck, S.; Cramer, S.; Baker, D. Nitrilotriacetamide: Synthesis in concentrated sulfuric acid and stability in water Synth. Commun. 1995, 25, 4123–4132.

 2.   Cramer, S.; Sucheck, S. J.; Skrzypczak-Jankun, E.; Smith, D. A. Facile synthesis of substituted nitrilotriacetamides. Tetrahedron Lett. 1992, 33, 7765–7768.

1.    Sucheck, S. J.; Pinkerton, A. A.; Smith, D. A. Characterization of [Pb(NO₃)(ntam)₂]NO₃ the first metal complex of the neutral tetradentate ligand nitrilotriacetamide (ntam). J. Chem. Soc., Chem. Commun. 1992, 367–368.