The University of Toledo

Jerry Nesamony

 

Dr. Nesamony began his academic career as an Assistant Professor of Pharmaceutics at the Appalachian College of Pharmacy (ACP) in Oakwood, Virginia in 2005.  At ACP, he developed and taught courses in Pharmaceutics, Extemporaneous Compounding, Sterile Products Compounding, and Pharmacokinetics for three years before joining the UT College of Pharmacy and Pharmaceutical Sciences in 2008.  Dr. Nesamony received a Ph.D. degree in Pharmaceutics from the University of Louisiana at Monroe, LA in 2005.  Prior to coming to graduate school in the United States, Dr. Nesamony earned the Bachelor of Pharmacy (B.Pharm) and Master of Pharmacy (M.Pharm) in Pharmaceutics degrees from the College of Pharmaceutical Sciences, Medical College, University of Kerala, India.  Dr. Nesamony’s graduate research was in the areas of oral and sub-cutaneous delivery of insulin and microemulsion-based synthesis of nanocrystals.

HONORS AND AWARDS

1. Outstanding Professor of the Year, 2011
2. Outstanding Faculty of the Year, 2012

CURRENT RESEARCH INTERESTS

Nanostructured systems and nanoparticulates for drug delivery:

1. Solid Lipid Nanoparticles (SLN): SLNs are prepared by a new protocol developed in our lab. Model drugs under investigation are primarily anti-cancer drugs used in colorectal, breast, and lung cancer.
2. Nanostructured aerosols (US Patent pending): Novel nanostructured aerosols were developed in our lab that can deliver poorly water-soluble compounds. Potential routes of administration include intranasal for local, systemic, or nose to brain targeting and pulmonary administration into the lungs.
3. Calcium alginate nanoparticles (CANp): Biopolymer nanoparticles comprising of calcium alginate are prepared using a new procedure developed in our lab. Research on utilitilizing CANp to deliver insulin via a biomimetic mode is currently being studied.
4. Thermoresponsive gels and self-gelling formulations for topical/transdermal drug delivery
5. Developing novel methods and technologies in sterile products compounding

PUBLICATIONS

THESIS

Nesamony J. 2000. Oral delivery of Insulin: An optimization. (Dissertation (M.Pharm), College of Pharmaceutical Sciences, Medical College, Trivandrum, Kerala, India).

DISSERTATION

Nesamony J. 2005. Microemulsions as reactors for nanoparticle synthesis. (Dissertation (Ph.D.), College of Pharmacy, University of Louisiana at Monroe, Monroe, LA )

JOURNAL PUBLICATIONS

1. Gandra SCR., Nguyen S., Nazzal SM., Alayoubi A., Jung R, and Nesamony J. 2013. Thermoresponsive fluconazole hydrogels for topical delivery: Rheological and mechanical properties, in vitro drug release, and anti-fungal efficacy, Pharmaceutical Development and Technology (accepted for publication 9/9/13)
2. Nesamony J., Shah IS., Kalra A., and Jung R, 2013. Nebulized oil-in-water nanoemulsion mists for pulmonary delivery: Development, physico-chemical characterization and in vitro evaluation, Drug Development and Industrial Pharmacy (accepted for publication 6/2/13)
3. Nesamony J., Kalra A., Majrad M., Boddu S.H.S., Jung R, Williams F.E., Schnapp A, Nauli S, and Kalinoski A. 2013. Development and characterization of nanostructured mists with potential for actively targeting poorly water-soluble compounds into the lungs, Pharmaceutical Research (Accepted for publication 5/14/13)
4. Boddu S.H.S, Nesamony J, 2013. Utility of transporter/receptor(s) in drug delivery to the eye, World Journal of Pharmacology, 2(1), 1-46.
5. Nesamony J., Zachar C.L., Jung R., Williams F.E., and Nauli S., 2013. Preparation, characterization, sterility validations, and in vitro cell toxicity studies of microemulsions possessing potential parenteral applications, Drug Dev. Ind. Pharm., 39(2), 240-251.
6. Nesamony J., Singh P.R., Nada S.E., Shah Z.A., and Kolling W.M., 2012. Calcium alginate nanoparticles synthesized through a novel interfacial cross-linking method as a potential protein drug delivery system, J. Pharm. Sci., 101(6), 2177-2184. (Top 10 most downloaded articles from the journal between April, 2012 and June 2012)
7. Nesamony, J., Manek, R.V., and Kolling, W.M., 2006. Characterizing water states in microemulsions using sub-ambient differential scanning calorimetry, American Pharmaceutical Review, 9(5): 44-53. 
8. Nesamony, J., and Kolling, W. M., 2005. IPM/DOSS/water microemulsions as reactors for silver sulfadiazine nanocrystal synthesis, Journal of Pharmaceutical Sciences, 94(6): 1310-1320.
9. Paul, W., Nesamony, J., and Sharma, C.P., 2002. Delivery of insulin from hydroxyapatite ceramic microspheres: preliminary in vivo studies, Journal of Biomedical Materials Research, 61(4): 660-662.
10. Nesamony, J., Anitha, Y., Sharma, C.P. and Poulose, S., 2001. In vivo absorption studies of insulin from an oral delivery system, Drug Delivery, 8(1): 19-23.

PUBLISHED ABSTRACTS

1. Nesamony, J., and Peeters, M.J., 2013. Active Learning & Technology: A Feasibility Pilot Study with Student Participation Technology. Annual Meeting of the American Association of Colleges of Pharmacy, Chicago, IL, United States, July 13-17, Volume 77.
2. Nesamony J., Manek R.V., and Kolling W.M. 2009. Structure and Dynamics of Self-Assembling Nanostructures in Isopropyl Myristate (IPM)/Di-Octyl Sodium Sulfosuccinate (DOSS)/Water Ternary Systems. Central Regional Meeting of the American Chemical Society, Cleveland, OH, United States, May 20-23, Pages CRM-073

BOOK CHAPTERS

1. Nesamony J., and Kolling, W.M., 2009. Modulation of crystal growth in microemulsion-based reactors using polymers, Pathak, Y., and Tran, H., (Eds), Center for Nanotechnology Education, Research and Application, Louisville, KY, pp 156-168.
2. Nguyen, S., Baki G, Nesamony J, and Boddu S.H.S., 2012. Vaginal Drug Delivery, Mitra, A.K. (Ed), Jones and Bartlett Learning, Burlington, MA. (In Press)
3. Lakkadwala S, Nguyen S, Nesamony J, and Boddu S.H.S. 2013. Use of smart polymers in drug delivery, In: Pharmaceutical Excipients: Chemistry, Functionality, & Regulatory Aspects, Edited by Narang AS, Metin C, and Boddu SHS, and published by Springer. (In press)

PATENTS

• US PATENT AND TRADEMARK OFFICE: Provisional patent application 1-54869 FILED: 03/15/13 “Nanoemulsions, Methods of Making and Methods of Using the Same”

PROFESSIONAL AFFILIATIONS

• Registered Pharmacist at the Pharmacy Council of Kerala, India, 1996 – present.
• Member of Society of Biomaterials and Artificial Organs, 1999 – present.
• Member of the American Association of Pharmaceutical Scientists, 2001 – present.
• Member of the Society of Rheology, 2003 – present.
• Member of the American Association of Colleges of Pharmacy, 2008.
• Member of the Rho Chi Society (Delta Alpha chapter), 2008.
• Member of American Association for the Advancement of Science, 2011 – present
• Kappa Psi (Beta Lamda chapter), 2012