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Dr. Mariann Churchwell received her bachelor and doctor of pharmacy degrees from Wayne
State University. Dr. Churchwell has completed both a pharmacy practice residency
at Detroit Receiving Hospital and a two-year pharmacotherapy research fellowship in
critical care nephrology at the University of Michigan.
Within her current position as an associate professor at The University of Toledo
College of Pharmacy and Pharmaceutical Sciences, Dr. Churchwell maintains a clinical
practice at The University of Toledo Medical Center with the Nephrology medical team
where she precepts pharmacy residents and students. She teaches and coordinates the
Nephrology PPT course and gives select lectures in the Advanced Applied Pharamacokinetics
course. Dr. Churchwell maintains an active research laboratory at The University of
Toledo College of Pharmacy and Pharmaceutical Sciences, where her research is primarily
focused in drug and solute removal kinetics during different dialysis modalities.
Dr. Churchwell is a full member of the American College of Clinical Pharmacy, and
a member of the American Society of Nephrology, American Association of Colleges of
Pharmacy, Ohio Society of Health-System Pharmacists and the Toledo Area Society of
Health System Pharmacists.
Publications:
Peer-Reviewed Articles
Churchwell MD, Pasko DA, Mueller BA. Daptomycin Clearance during Modeled Continuous
Renal Replacement Therapy. Blood Purif 2006;24:548-554.
Churchwell MD, and Mueller BA. Selected Pharmacokinetic Issues in Patients with Chronic
Kidney Disease. Blood Purif 2007;25(1):133-8.
Churchwell MD, Pasko DA, Btaiche IF, Jain J, Mueller BA. Trace Element Removal during In vitro and In vivo Continuous Hemodialysis. Nephrol Dial Transplant 2007 Oct;22(10):2970-2977.
Churchwell MD, Btaiche IF, Pasko DA, and Mueller BA. Reply: Nephrol Dial Transplant 2008;23:1462-63.
Churchwell MD, Pasko DA, Smoyer WE and Mueller BA. Enhanced Clearance of Highly Protein-bound Drugs
by Albumin Dialysate during Modeled Continuous Hemodialysis. Nephrol Dial Transplant
2009;24(1):231-8.
Vilay AM, Churchwell MD, Mueller BA. Drug Metabolism and Clearance in Acute Kidney Injury. Crit Care 2008;12(6):235.
Stevenson JM, Patel JH, Churchwell MD, Vilay AM, Depestel DD, Sörgel F, Kinzig M,
Jakob V, Mueller BA. Ertapenem Clearance during Modeled Continuous Renal Replacement
Therapy. Int J Artif Organs 2008;31(12):1027-34.
Pasko DA, Churchwell MD, Btaiche IF, Jain J, Mueller BA. from the Renal Replacement Therapy Kinetics Study
Group. Continuous Venovenous Hemodiafiltration Trace Element Clearance in Pediatric
Patients: A Case Series. Pediatr Nephrol 2009;24(4):807-13.
Churchwell MD, Mueller BA Drug Dosing during Continuous Renal Replacement Therapy. Semin Dial 2009
Mar-Apr;22(2):185-8.
Salama NN, Segal JH, Churchwell MD, Patel JH, Gao L, Heung M, Mueller BA. Intradialytic Administration of Daptomycin
in End Stage Renal Disease Patients on Hemodialysis. Clin J Am Soc Nephrol 2009;4(7):1190-4.
Patel JH, Churchwell MD, Seroogy JD, Barriere SL, Grio M, Mueller BA. Telavancin and Hydroxy propyl-beta-cyclodextrin
Clearance during Continuous Renal Replacement Therapy: an In vitro Study. Int J Artif Organs. 2009;32(10):745-51.
Salama NN, Segal JH, Churchwell MD, Patel JH, Gao L, Heung M, Mueller BA. Single-dose Daptomycin Pharmacokinetics in
Chronic Haemodialysis Patients. Nephrol Dial Transplant. 2010;25(4):1279-84.
Peeters MJ, Churchwell MD, Mauro LS, Cappelletty DM, Stone GE. A Student-inclusive Pharmacotherapeutic Textbook
Selection Process. Currents in Pharmacy Teaching & Learning 2010:2(1):31-38.
Vilay AM, Shah KH, Churchwell MD, Patel JH, DePestel DD, Mueller BA. Modeled Dalbavancin Transmembrane Clearance during
Intermittent and Continuous Renal Replacement Therapies. Blood Purif. 2010 Jun 24;30(1):37-43
Dotson B, Lynn S, Savakis K, Churchwell MD. Physical Compatibility of 4% Sodium Citrate with Selected Antimicrobial Agents.
Am J Health Syst Pharm. 2010 Jul 15;67(14):1195-8.
Dotson B, Churchwell MD. Physical Compatibility of Catheter Lock Solutions with 4% Sodium Citrate and 18%
Saline, Fluconazole, and Micafungin. Am J Health Syst Pharm 2011 Mar 1;68(5):377-8.
Pasko DA, Churchwell MD, Salama NN, Mueller BA: Longitudinal Hemodiafilter Performance
in Modeled Continuous Renal Replacement Therapy. Blood Purif 2011;32:82-88
Book Chapter(s)
Sowinski KM and Churchwell MD. Chapter:Hemodialysis and Peritoneal Dialysis. Pharmacotherapy: A Pathophysiologic
Approach. 8th Edition McGraw Hill 2010. accepted for publication.
Recent Abstracts
Churchwell MD, Tam VH, Hou JG. Colistin Clearance during Continuous Dialysis. Blood Purif 2008;26:171
(Abstract #17)
Peeters MJ, Churchwell MD, Mauro LS, Cappelletty DM, Stone GE. A Rasch-based Pharmacotherapeutics Textbook
Selection Methodology. American Associations of Colleges of Pharmacy July 2008 Chicago,
IL
Salama NN, Segal J, Churchwell MD, Patel JH, Gao L, Heung M, Mueller BA. Intradialytic Administration of Daptomycin
in End Stage Renal Disease and Patients on Hemodialysis. J Am Soc Nephrol 2008;19:737A
(Abstract #SA-PO2772)
Salama NN, Segal J, Churchwell MD, Patel JH, Gao L, Heung M, Mueller BA. Daptomycin Serum Concentrations are Maintained
in a 2- and 3-Day Interdialytic Period. J Am Soc Nephrol 2008;19:738A (Abstract #SA-PO2773)
Churchwell MD. Vancomycin Clearance during Slow Low Efficiency Dialysis. Pharmacother 2009;29(10):220-221e
(Abstract #135)
Zukkoor S, Mauro V, Churchwell M. Atorvastatin 80 mg Daily Therapy for Acute Coronary Syndrome: An Assessment of Short
and Long Term Tolerability. Ohio College of Clinical Pharmacy October 2009 Cleveland,
OH (Abstract #30)
Zukkoor S, Mauro V, Churchwell M. Atorvastatin 80 mg Daily Therapy for Acute Coronary Syndrome: An Assessment of Short
and Long Term Tolerability. 44th American Society of Health-System Pharmacy 2009 Mid-Year
Meeting Las Vegas, NV
Murray TD, Churchwell MD, Vilay AM, Mueller BA. Anticonvulsant drug clearance by in vitro models of slow low
efficiency dialysis, continuous veno-venous hemofiltration, and continuous dialysis
with albumin-supplemented dialysate. 45th American Society of Health-System Pharmacy
2010 Mid-Year Meeting Anaheim, CA
Recent Presentations
Alternative, Complementary, Holistic, Natural Medicine and the Kidney Patient. American
Society of Health System Midyear Clinical Meeting Invited Platform Presentation ACPE (1.0) Las Vegas, NV December 2007.
The Influence of Continuous Renal Replacement Therapy on Drug Therapy. Detroit Medical
Center Critical Care Symposium. ACPE (1.0) Dearborn, MI January 2008.
Nephrology: Basics. University of Toledo Medical Center, 1.0 ACPE Toledo, OH June
2008
Nutrition and Electrolyte Issues during Renal Dysfunction and Support. American College
of Clinical Pharmacy Annual Meeting Invited Platform Presentation Continuing education
ACPE (1.0) Louisville, KY Oct 2008
Modes of Renal Replacement Therapy. American College of Clinical Pharmacy Annual Meeting
Invited Platform Presentation Continuing education ACPE (1.0) Louisville, KY Oct 2008
Dialysis Kinetics. Nephrology lecture series. University of Toledo Medical Center.
Toledo, OH Jan 2009
Chronic Kidney Disease Update. Michigan Pharmacists Association Annual Meeting. ACPE
(1.5) Detroit, MI Feb 2009
Current Research
In vitro Study Clearance of Gentamicin during Modeled Slow Low Efficiency Dialysis
(SLED): A Pilot Study2007. PI: Mariann D. Churchwell. University of Toledo College of Pharmacy
In vitro Study Clearance of Vancomycin during Modeled Slow Low Efficiency Dialysis
(SLED): A Pilot Study 2007. PI: Mariann D. Churchwell. University of Toledo College of Pharmacy
An in vitro study of Colistimethate Sodium Clearance during Modeled Continuous Hemofiltration
and Slow Low Efficiency Dialysis (SLED) 2008. PI Mariann D. Churchwell. University of Toledo College of Pharmacy.
An in vitro study of Valproic Acid and Carbamazepine Clearance during Modeled Continuous
Hemofiltration and Slow Low Efficiency Dialysis (SLED) 2008. PI Mariann D. Churchwell Co-Investigator: Bruce A. Mueller. University of Toledo College of Pharmacy.
Retrospective Evaluation of Calcineurin Inhibitors and Sirolimus in Adult Kidney Transplant
Patients. PI: Shobha Ratnam Co- Investigators: Mariann Churchwell and Michael Rees. University of Toledo Medical Center and College of Pharmacy.
Retrospective analysis of urinary tract infections in renal transplant patients at
University of Toledo Medical Center. PI: Mariann Churchwell Co- Investigator: Shobha Ratnam. University of Toledo Medical Center and College
of Pharmacy.
Atorvastatin 80mg Daily Therapy for acute Coronary Syndrome: An assessment of Short
and Long Term Tolerability. PI: Vince Mauro Co- Investigator: Mariann Churchwell and Sarah Zukkoor. University of Toledo Medical Center and College of Pharmacy.
Retrospective Evaluation of Circuit Survival Time with Epoprostenol, Unfractionated
Heparin, or the Combination in Critically Ill Patients receiving Continuous Venovenous
Hemodiafiltration 2010-11. PI: Mariann D. Churchwell Co-Investigators: Bryan Dotson, Rose Jung, Dante Cammarata and Steven Martin. University
of Toledo Medical Center and College of Pharmacy.
Retrospective evaluation of the use of an albumin-furosemide infusion in patients
with acute kidney injury. 2010-2011. PI: Mariann D. Churchwell Co-Investigators: Joseph Williams, Tatyana Barkhimer and Deepak Malhotra. University
of Toledo Medical Center and College of Pharmacy.
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