Training
- B.S., Biomedicine, 1989, Nankai University, Tianjin, China
- M.S., Biochemistry, 1996, Baylor University, Waco, Texas
- Ph.D., Cell Regulation, 2001, University of Texas Southwestern Medical Center, Dallas, Texas
Appointments
- Research Molecular Geneticist, Suzhou Medical College, Suzhou, China, 1989-1994
- Research Associate, The Scripps Research Institute, La Jolla, California, 2001-2005
- Assistant Professor, Department of Physiology and Pharmacology, University of Toledo College of Medicine, 2005-
Research Interests
- Folding, assembly and trafficking of membrane bound transporters and receptors.
Representative Publications
- Ruan, C., Gu, J., Wang, X., Chu, X., and Pan, J. (1993) Application of GPIIIa gene Taq1 polymorphism to determination of carrier status in Glanzmann's thrombastheniz families of Chinese origin. Thromb. Haemostasis 68, 64-69.
- Wang, X., Chu, X., Jiang, H., and Ruan, C. (1993) Intragenic variable number tandom repeats in coagulation factor VIII gene of Chinese origin. National Medical Journal of China 73, 206-208, 252.
- Gu, J., Xu, W., Wang, X., Wu, Q., Chi, C., and Ruan, C. (1993) Identification of a nonsense mutation at amino acid 584-arginine of platelet glycoprotein IIb in patients with type I Glanzmann thrombasthenia. Brit. J. Haematol. 83, 442-449.
- Wang, X., Chu, X., and Ruan, C. (1995) St14 (DXS52) VNTR in the Chinese population and its application tog enetic diagnosis of hemophilia A. Nouv. Rev. Fr. Hematol. 37, 183-186.
- Wang, X., Unruh, M.J., and Goodman, J.M. (2001) Discrete targeting signals direct Pmp47 to oleate-induced peroxisomes in Saccharomyces cerevisiae. J. Biol. Chem. 276, 10897-10905.
- Wang, X., McMahon, M.A., Shelton, S.N., Nampaisansik, M., Ballard, J.L., and Goodman, J.M. (2004) Multiple targeting modules on peroxisomal proteins are not redundant: Discrete functions of targeting signals within Pmp47 and Pex8p. Mol. Biol. Cell 15, 1702-1710.
- Wang, X., Matteson, J., An, Y., Moyer, B., Yoo, J-S., Bannykh, S., Wilson, I.A., Riordan, J.R., and Balch, W.E. (2004) COPII-dependent export of cystic fibrosis transmembrane conductance regulator from the ER uses a di-acidic exit code. J. Cell. Biol. 167, 65-74.
- Plutner, H., Gurkan, C., Wang, X., LaPointe, P., and Balch, W.E. (2005) Microsome-based assay for analysis of endoplasmic reticulum to Golgi transport in mammalian cells. In: Cell Biology: A Laboratory Handbook, Celis, J.E., Editor. Elsevier, San Diego. Vol. 2, p 209-214.
- Wang, X., Venable, J., LaPointe, P., Hutt, D.M., Koulov, A.V., Coppinger, J., Gurkan, C., Kellner, W., Matteson, J., Plutner, H., Riordan, J.R., Kelly, J.W., Yates, J.R., III, and Balch, W.E. (2006) Hsp90 co-chaperone Aha1 rescues misfolding of CFTR in cystic fibrosis. Cell 127: 803-815.
- Wang, X., Koulov, A.V., Kellner, W.A., Riordan, J.R. and Balch, W.E. (2008) Chemical and biological folding contribute to temperature-sensitive ΔF508 CFTR trafficking. Traffic 9: 1878-1893.
