Biochemistry & Cancer Biology

Student-Faculty Publications

PUBLICATIONS (bold = BCB student or alumni, underline = BCB faculty) 


Mbah, N.E.,
Overmeyer, J.H., and Maltese, W.A.  (2016) Disruption of endolysosomal trafficking pathways in glioma cells by methuosis-inducing indole-based chalcones.  Cell Biol. Toxicol. Epub ahead of print DOI:10.1007/s10565-016-9369-2

Trabbic, C.J., George, S.M., Alexander, E.M., Du, S., Offenbacher, J.M., Crissman, E.J., Overmeyer, J.H., Maltese, W.A., and Erhardt, P.W. (2016) Synthesis and biological evaluation of isomeric methoxy substitutions on anti-cancer indolylpyridinyl-propenones: effects on potency and mode of activityEur. J. Med. Chem. 122:79-91.

Ziske, M.A., Pettee, K.M., MaNada, K., Rubinic, K., and Eisenmann, K.M.  (2016) SMIFH2-mediated mDia formin functional inhibition potentiates chemotherapeutic targeting of human ovarian cancer spheroids. Biochem. Biophys. Res. Comm. 472:33-39.


Arden, J.D.
, Lavik, K.I., Rubinic, K.A., Chiaia, N., Khuder, S.A., Howard, M.J., Nestor-Kalinoski, A.L., Alberts, A.S., and Eisenmann, K.M. (2015) Small molecule agonists of mammalian Diaphanous-related (mDia) formins reveal an effective glioblastoma anti-invasion strategy.  Mol. Biol. Cell, Sept 9 pii: mbc.E14-11-1502. [Epub ahead of print]


Blomquist, T.M., Brown, R.D., Crawford, E.L., de la Serna, I., Williams, K., Yoon, Y., Hernandez, D.A. and Willey, J.C. (2013) Cis-acting genetic variation contributes to CCAAT/enhancer binding protein gamma (CEBPG) expression variation in human bronchial epithelial cells.  Gene Regul. Syst. Bio., 7:125-138.

Datar, I., Tegegne, H., Qin, K., Al-Mulla, F., Bitar, M.S., Trumbly, R.J., and Yeung, K.C. (2014) Genetic and epigenetic control of RKIP transcription. Crit. Rev. Oncogen 19:417-430.

Mehrotra, A., Mehta, G., Aras, S., Trivedi, A., and de la Serna, I.L. (2014) SWI/SNF Chromatin remodeling enzymes in melanocyte differentiation and melanoma.  Crit. Rev. Eukaryot. Gene Expr. 24:151-161.

Mehrotra, A., Saladi, S.V., Trivedi, A., Aras, S., Qi, H., Jayanthy, A., Setaluri, V., and de la Serna, I. (2014) Modulation of BRAHMA expression by the mitogen-activated proteinkinase/extracellular signal regulated kinase pathway is associated with changes in melanoma proliferation. Arch. Biochem. Biophys. 153:125-135.

Pettee, K., Dvorak, K.M., Nestor-Kalinoski, A., and Eisenmann, K.M.  (2014) An mDia2/ROCK signaling axis regulates invasive egress from epithelial ovarian cancer spheroids.  PLoS ONE 9:e90371. 

Trabbic, C.J., Dietsch, H.M., Alexander, E.M., Nagy, P.I., Robinson, M.W., Overmeyer, J.H., Maltese, W.A., and Erhardt, P.W. (2014) Differential induction of cytoplamic vacuolization and methuosis by novel 2-indolyl-substituted pyridinylpropenones. ACS Med. Chem. Lett. 5:73-77.


Jetson, R., Malik, N., Luniwal, A., Chari, V., Ratnam, M., and Erhardt, P. (2013) Practical synthesis of a chromene analog for use as a retinoic acid receptor alpha antagonist lead compound. Eur J Med Chem 63:104-108.

Kothandapani, A., Sawant, A., Dangeti, V.S.M.N., Sobol, R.W., and Patrick, S.M. (2013) Epistatic role of base excision repair and mismatch repair pathways in mediating cisplatin cytotoxicity. Nucleic Acids Res. 41:7332-7343.

Marathe, H.G., Mehta, G., Zhang, X., Datar, I., Mehrotra, A., Yeung, K.C. and de la Serna, I.L.  (2013) SWI/SNF enzymes promote SOX10-mediated activation of meyline gene expression.  PLoS One 16:e69037.

Patki, M., Chari, V., Sivakumaran, S., Gonit M., Trumbly, R., and Ratnam, M. (2013) The ETS domain transcription factor Elk1 directs a critical component of growth signaling by the androgen receptor in prostate cancer cells. J. Biol. Chem. 288:11047-11065.

Saladi, S.V., Wong, P.G., Trivedi, A.R., Marathe, H.G., Keenen, B., Aras, S., Liew, Z.Q., Setaluri, V., and de la Serna, I.L. (2013) BRG1 promotes melanoma survival in UV-irradiated melanoma cells by cooperating with MITF to activate the melanoma inhibotor of apoptosis gene. Pigment Cell Melanoma Res. 26:377-391.


Ren, G., Feng, J., Datar, I., Yeung, A.H., Saladi, S.V., Feng, Y., de la Serna, I., and Yeung, K.C. (2012) A micro-RNA connection in BRaf(V600E)-mediated premature senescence of human melanocytes. Int. J. Cell Biol. 2012:913242.

Robinson, M.W., Overmeyer, J.H., Young. A.M., Erhardt P.W. and Maltese, W.A. (2012) Synthesis and evaluation of indole-based chalcones as inducers of methuosis, a novel type of non-apoptotic cell death. J. Med. Chem. 55:1940-1956.

Wyse, M.M.,
Lei, J., Nestor-Kalinoski, A.L., and Eisenmann, K. (2012) Dia-Interacting protein (DIP) imposes migratory plasticity in mDia2-dependent tumor cells in three-dimensional matrices. PLos ONE 7:e45085. 

Last Updated: 1/11/17