Biochemistry & Cancer Biology

Student-Faculty Publications

PUBLICATIONS (bold = BCB student or alumni, underline = BCB faculty)


Datar, I., Tegegne, H., Qin, K., Al-Mulla, F., Bitar, M.S., Trumbly, R.J., and Yeung, K.C. (2014) Genetic and epigenetic control of RKIP transcription. Crit. Rev. Oncogen 19:417-430.

Mehrotra, A., Mehta, G., Aras, S., Trivedi, A., and de la Serna, I.L. (2014) SWI/SNF Chromatin remodeling enzymes in melanocyte differentiation and melanoma.  Crit. Rev. Eukaryot. Gene Expr. 24:151-161.

Pettee, K., Dvorak, K.M., Nestor-Kalinoski, A., and Eisenmann, K.M.  (2014) An mDia2/ROCK signaling axis regulates invasive egress from epithelial ovarian cancer spheroids.  PLoS ONE 9:e90371. 


Jetson, R., Malik, N., Luniwal, A., Chari, V., Ratnam, M., and Erhardt, P. (2013) Practical synthesis of a chromene analog for use as a retinoic acid receptor alpha antagonist lead compound. Eur J Med Chem 63:104-108.

Marathe, H.G., Mehta, G., Zhang, X., Datar, I., Mehrotra, A., Yeung, K.C. and de la Serna, I.L.  (2013) SWI/SNF enzymes promote SOX10-mediated activation of meyline gene expression.  PLoS One 16:e69037.

Patki, M., Chari, V., Sivakumaran, S., Gonit M., Trumbly, R., and Ratnam, M. (2013) The ETS domain transcription factor Elk1 directs a critical component of growth signaling by the androgen rceptor in prostate cancer cells. J. Biol. Chem. [Epub ahead of print]

Saladi, S.V., Wong, P.G., Trivedi, A.R., Marathe, H.G., Keenen, B., Aras, S., Liew, Z.Q., Setaluri, V., and de la Serna, I.L. (2013) BRG1 promotes melanoma survival in UV-irradiated melanoma cells by cooperating with MITF to activate the melanoma inhibotor of apoptosis gene. Pigment Cell Melanoma Res. 26:377-391.


Ren, G., Feng, J., Datar, I., Yeung, A.H., Saladi, S.V., Feng, Y., de la Serna, I., and Yeung, K.C. (2012) A micro-RNA connection in BRaf(V600E)-mediatd premature senescence of human melanocytes. Int. J. Cell Biol. 2012:913242.

Robinson, M.W.,Overmeyer, J.H., Young. A.M., Erhardt P.W. and Maltese, W.A. (2012) Synthesis and evaluation of indole-based chalcones as inducers of methuosis, a novel type of non-apoptotic cell death. J. Med. Chem. 55:1940-1956.

Wyse, M.M.,
Lei, J., Nestor-Kalinoski, A.L., and Eisenmann, K. (2012) Dia-Interacting protein (DIP) imposes migratory plasticity in mDia2-dependent tumor cells in three-dimensional matrices. PLos ONE 7:e45085. 


Overmeyer, J.H., Young, A.M., Bhanot, H. and Maltese, W.A. (2011) A Chalcone-related small molecule that induces methuosis, a novel form of non-apoptotic cell death, in glioblastoma cells.  Mol. Cancer 10:69.

Salazar, M.D.,
Ratnam, M., Patki, M., Kosovic, I., Trumbly, R., Iman, M., and Ratnam, M. (2011) During hormone depletion or tamoxifen treatment of breast cancer cells the estrogen receptor apoprotein supports cell cycling through the RARα1 apoprotein.  Breast Cancer Res., 13:R18.


Arora, S., Kothandapani, A., Tillison, K., Kalman-Maltese, V., Patrick, S.M. (2010) Downregulation of XPF-ERCC1 enhances cisplatin efficacy in cancer cells.  DNA Repair (Amst). 9:745-753.

Bhanot, H., Young, A.M., Overmeyer, J.H., and Maltese, W.A. (2010) Induction of nonapoptotic cell death by activated Ras requires inverse regulation of Rac1 and Arf6.  Molec. Cancer Res., 8:1358-1374.

Keenen, B., Qui, H., Saladi, S.V., Yeung, M., and de la Serna, I.L. (2010) Heterogeneous SWI/SNF complexes promote expression of MITF-target genes in melanoma.  Oncogene 29:81-92.

Lee, J.H., Zhou, S., and Smas, C.M. (2010) Identification of RANBP16 and RANBP17 as novel interaction partners for the bHLH transcription factor E12.  J. Cell. Biochem., 111:195-206.

Saladi, S.V. and de la Serna, I.L. (2010) ATP dependent chromatin remodeling enzymes in embryonic stem cells.  Stem Cell Rev., 6:62-73. 

Saladi, S.V., Keenen, B., Marathe, H.G., Qi, H.,
Chin, K.V., and de la Serna, I.L. (2010) Modulation of extra-cellular matrix/adhesion molecular expression by BRG1 is associated with increased melanoma invasiveness.  Mol. Cancer 9:280.

Saladi, S.V., Marathe, H.G., and de la Serna, I.L. (2010) Switching on the transcriptional circuitry in melanoma. Epigenetics, 5:469-475.

Sivakumaran, S., Zhang, J., Kelly, K.K., Gonit, M., Hao, H., and Ratnam, M. (2010) Androgen activation of the folate receptor alpha gene through partial tethering of the androgen receptor by C/EBPalpha.  J. Steroid Biochem. Mol. Biol., 122:333-340.

Wu, Y., Zhou, S., and Smas, C.M. (2010) Downregulated expression of the secreted glycoprotein follistatin-like 1 (Fstl1) is a robust hallmark of preadipocyte to adipocyte conversion.  Mech. Dev., 127:183-202.


Bhrigu, V. and Trempe, J.P. (2009) Adeno-associated virus infection of murine fibroblasts with help provided by mouse adenovirus.  Virol. 390:22-30.

Collaco, R., Bevington, J., Bhrigu, V., Kalman-Maltese, V., and Trempe, J.P. (2009) Adeno-associated virus and adenovirus coinfection induces a cellular DNA damage and repair response via redundant phosphatidylinositol 3-like kinase pathways.  Virol. 392:24-33.

Edelbrock, M.A., Kaliyaperumal, S., Williams, K.J. (2009) DNA mismatch repair efficiency and fidelity are elevated during DNA synthesis in human cells.  Mutat. Res. 662:59-66

Elnakat, H., Gonit, M., d'Alincourt Salazar, M., Zhang, J., Basrur V., Gunning, W., Kamen, B., and Ratnam, M. (2009) Regulation of folate receptor internalization by protein kinase C alpha.  Biochemistry 48:8249-8260.

Kaul, A., and Maltese, W. (2009) Killing of cancer cells by the photoactivatable protein kinase C inhibitor, calphostin C, involves induction of endoplasmic reticulum stress.  Neoplasia 11:823-834.

Keenen, B., de la Serna, I.L. (2009) Chromatin remodeling in embryonic stem cells: regulating the balance between pluripotency and differentiation.  J. Cell Phys. 219:1-7.

Liu, K., Zhou, S., Kim, J-Y., Tillison, K., Majors, D., Rearick, D., Lee, J.H., Fernandez-Boyanapalli, R.F., Barricklow, K., Houston, M.S., and Smas, C.M. (2009) Functional analysis of FSP27 protein regions for lipid droplet localization, caspase-dependent apoptosis, and dimerization with CIDEA.  Am. J. Physiol Endocrinol. Metab., 297:E-1395-E413.

Schroering, A.G., Kothandapani, A., Patrick, S.M., Kaliyaperumal, S., Sharma, V.P., and Williams, K.J. (2009) Prolonged cell cycle response of HeLa cells to low-level alkylation exposure.  Cancer Res. 69:6307-6314.

Zhang, J., Gonit, M., Salazar, MD, Shatnawi, A., Shemshedini, L., Trumbly, R., and Ratnam, M. (2009) C/EBPalpha redirects androgen receptor signaling through a unique bimodal interation.  Oncogene  [Epub ahead of print] PMID: 19901962

PRESENTATIONS (bold = BCB student or alumni, underline = BCB faculty)


Arora, S., Maltese, V.K., and Patrick, S. XPF-ERCC1 and resistance to cisplatin in cancer cells.  12th Annual Midwest NDA Repair Symposium, Louisville, KY, May 16-17, 2010. 

Saladi, S.V., Keenen, B., Marathe, H.G., Qi, H., Chin, K.V. and de la Serna, I.L. SWI/SNF chromatin remodeling enzymes - Epigeneic modulators in melanoma invasiveness and survival. Mechanisms & Models of Cancer meeting, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, August 17-21, 2010.


Arora, S., Kothandapani, A., Tillison, K., Maltese, V.K., and Patrick, S.  Cisplatin cytotoxicity in non small cell lung cancer cell lines: Role of XPF-ERCC1.  11th Annual Midwest NDA Repair Symposium, Ann Arbor, MI, May 16-17, 2009.  

Dangeti, V.S.M.N., Tillison, K., and Patrick, S.  Interaction of nucleotide excision repair proteins with cisplatin interstrand crosslink (ICL).  11th Annual Midwest NDA Repair Symposium, Ann Arbor, MI, May 16-17, 2009.  

Saladi, S.V., Keenen, B., Qi, H., Chin, K-V., and de la Serna, I.  Role of SWI/SNF chromatin remodeling enzymes in UV-damage response.  11th Annual Midwest NDA Repair Symposium, Ann Arbor, MI, May 16-17, 2009.  

Saladi, S.V., Keenen, B., Qi, H., Marathe, H., and de la Serna, I.L. Epigeneic regulation of the response to UVR by SWI/SNF chromatin remodeling enzymes.  Environmental Health Science: Regional Showcase of Fellows, Cincinnati, OH, Sept. 18, 2009.

Saladi, S.V., Qi, H., Chin, K-V., and de la Serna, I.  Oncogenic BRAF (V600E) induced de-regulation of SWI/SNF chromatin remodeling enzyme function.  Case Comprehensive Cancer Center, Signaling in Cancer Symposium, Cleveland, OH, May 18-19, 2009.

Saladi, S.V., Qi, H., Chin, K-V., and de la Serna, I.  Oncogenic BRAF (V600E) induced de-regulation of SWI/SNF chromatin remodeling enzyme function.  International Melanoma Congress, Boston, MA, Nov. 1-4, 2009.  

Last Updated: 3/22/15