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Health Science Campus, Mail Stop #1010
3000 Arlington Avenue
Toledo, OH 43614
Khew-Voon Chin, Ph.D.
My laboratory is interested in novel cAMP signal transduction mechanisms mediated by the regulatory subunit of the camp-dependent protein kinase, through its interaction with various other proteins targets in addition to the catalytic kinase subunit. Another major interest centers on the use of expression genomic to delineate the factors that are involved in drug resistance in cancer. Recently, observations from such studies resulted in the discovery of a molecular target that was further subjected to high-throughput screening for small molecule intervention. Our laboratory has identified lead compounds that were further exploited for development into potential therapeutic for modulating cholesterol levels via the reverse cholesterol transport pathway.
Member of the mentoring faculty for the Biomedical Sciences Graduate Program (Cancer Biology Track).
Ph.D. 1988 Rutgers University, NJ
B.A. 1983 Wittenberg University, OH
RECENT ACADEMIC APPOINTMENTS:
2005-present Assoc. Prof. of Medicine, Biochemistry & Cancer Biology, Medical University of Ohio
2005-present Director of Program in Genomic Medicine, Medical University of Ohio
2002-2005 Associate Research Professor, Department of Chemical Biology, Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers University
1993-2002 Assistant Professor, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey
Chin, K.-V., Seifer, D.B., Feng, B., Lin, Y., Shih, W. "DNA Microarray Analysis of the Expression Profiles of Granulosa Cells as a Function of Ovarian Reserve" Fertility & Sterility, 77:1214-1218, 2002.
Chin, K.-V., Yang, W.L., Ravatn, R., Kita, T., Reitman, E., Vettori, D., Cvijic, M.E., Shin, M., and Iacono, L. "Reinventing the Wheel of cyclic AMP: Novel mechanisms of camp signaling" Ann. N.Y. Acad. Sci., 968:49-64, 2002.
Zheng, X., Ravatn, R., Lin, Y., Shih, W., Rabson, A., Strair, R., Huberman, E., Conney, A., and Chin, K.-V. "Analysis of the mechanisms of TPA induced differentiation in HL-60 cells by expression profiling with DNA microarray", Nuclei Acid Res., 30:4489-4499, 2002.
Wong, Y.F., Selvanayagam, Z.E., Wei, N.C., Porter, J., Vittal, R., Hu, R., Lin, Y., Liao, J., Shih, W.C., Cheung, T.H., Lo, W.K., Yim, S.F., Yip, S.K., Ngong, T., Siu, N., Chan, K.Y., Chan, C.S., Kong, T., Kutlina, E., McKinnon, R.D., Denhardt, D.T., Chin, K.-V., and Chung, K.H. Expression Genomics of Cervical Cancer: Molecular Classification and Prediction of Radiotherapy Response by DNA Microarray. Clin. Cancer Res., 9:5486-5492, 2003.
Kita, T., Goydos, J., Reitman, E., Ravatn, R., Kikuchi, Y., and Chin, K.-V. "Extracellular camp-dependent protein kinase (ECPKA) in melanoma", Cancer Lett., 208:187-191, 2004.
Selvanayagam, Z.E. Cheung, T.H., Wei, N., Vittal, R., Lo, K.W.K., Yeo, W., Kita, T., Ravatn, R. Chung, T.K.H., Wong, Y.F., and Chin, K.-V. "Prediction of Chemotherapeutic Response in Ovarian Cancer by DNA Microarray Expression Profiling", Cancer Genet. Cytogenet., 154:63-66, 2004.
Vittal, R., Selvanayagam, Z.E., Hong, J., Chin, K.-V., and Yang, CS "Gene expression Changes Induced by Green Tea Polyphenol (-)-Epigallocatechin-3-Gallate in Human Bronchial Epithelial 21BES Cells by DNA Microarray", Mol. Cancer Ther., 3:1091-1099, 2004.
Chin, K.-V., Selvanayagam, Z.E., Vittal, R., Yang, CS, Kita, T., Kudoh, K., Shih, W.C., Yong, L., Wong, Y.F., Cheung, T.H., Chung, T.K.H. "Application of Expression Genomics in Drug Development and Genomic Medicine", Drug Dev. Res., 62:124-133, 2004.
Hou, Z., Lambert, J.D., Chin, K.-V., and Yang, C.S. "Effects of tea polyphenols on signal transduction pathways related to cancer chemoprevention," Cancer Res., 65:1631-1634, 2005.
Ravatn, R., Wells, V., Nelson, L., Vettori, D., Mallucci, L., and Chin, K.-V. "Circumventing Multidrug Resistance in Cancer by Beta-Galactoside Binding Protein an Anti-proliferative Cytokine", Cancer Res., 65:1631-1634, 2005.
Chin, K.-V., Albanza, L., Fujii, K., Kudoh, K., Kita, T., Kikuchi, Y., Selvanayagam, Z.E., Wong, Y.F., Lin, Y., and Shih, W.C. "Application of expression genomics for predicting treatment response in cancer." Ann. NY Acad. Sci. 1058:186-195, 2005.
Hou, Z., Sang, S., You, H., Lee, M.J., Hong, J., Chin, K.-V., and Yang, C.S. "Mechanisms of action of (-)-epigallocatechin-3-gallate: auto-oxidation-dependent inactivation of epidermal growth factor receptor and direct effects on growth inhibition in human esophageal cancer KYSE 150 cells." Cancer Res. 65:8049-8056, 2005.
Liang, L., Chen, J., Vittal, R., Selvanayagam, Z.E., McAteer, J.A., Deng, L., Tischfield, J., Chin, K.-V., and Sahota, A. "Expression profiling of crystal-induced injury in human kidney epithelial cells." Nephron Physiol. 103:53-62, 2006.
El-Okdi, N., Smaili, S., Raju, V., Shidyak, A., Gupta, S., Fedorova, L., Elkareh, J., Periyasamy, S., Shapiro, A.P., Kahaleh, M.B., Malhotra, D., Xie, Z., Chin, K.-V., and Shapiro, J.I. "Effects of cardiotonic steroids on dermal collagen synthesis and wound healing." J. Appl. Physiol. 105:30-36, 2008.
Szkudlarek, M., Bosio, R.M., Wu, Q., and Chin, K.-V. "Inhibition of angiogenesis by extracellular protein kinase A." Cancer Lett. 283:28-73, 2009.