Biochemistry & Cancer Biology

Kandace J. Williams, Ph.D.

kjw Kandace J. Williams, Ph.D.
Associate Dean for College of Medicine & Life Sciences Graduate 
Professor of Biochemistry & Cancer 
Director, Cancer Biology Track Biomedical Sciences Program
kandace.williams@utoledo.edu 

RESEARCH INTERESTS:

Since 2013, I have been Associate Dean for the College of Medicine & Life Sciences (UT-COM&LS) Graduate Programs, as well as the Director of the Biomedical Sciences Program in Cancer Biology research training track. The Associate Dean position requires me to be involved with all of the COM&LS graduate programs, including the MD/PhD dual degree program, all of the PhD and MSBS Biomedical Science Program training tracks, MSBS-Medical Science for premedical students, MSBS-Medical Physics, MSBS-Oral Biology for Dentistry residents, MSBS-Orthopedic Sciences, MSBS-Human Donation Sciences, MSBS-Physician Assistant studies, and MSBS-Assistant in Pathology. Several of the above graduate degrees are in clinical areas of study, requiring much different training than for a research career, however, all of the clinical programs are very well organized by each Program Director. The majority of my time is spent with the Biomedical Science Program research training tracks.  

EDUCATION:

1980 B.S. (Cum Laude) Medical Technology, University of Alaska Anchorage
1987 Ph.D. Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH
1988-1991 Postdoctoral Fellow, Joseph Gottstein Memorial Cancer Research Laboratory, Dept. of Pathology, University of Washington College of Medicine, Seattle, WA

ACADEMIC APPOINTMENTS:

2013-present Associate Dean for College of Medicine & Life Sciences (UT COM&LS) Graduate Programs
2013-present Director, Biomedical Sciences Cancer Biology track
2013-present Chair of Research Compliance for Export Control 
2006-present Professor, Dept. of Biochemistry & Cancer Biology, University of Toledo COM&LS
2001-2006 Associate Professor, Dept. of Biochemistry & Cancer Biology, Medical University of Ohio (MUO)
1997-2001 Associate Professor, Biomedical Program, Univ. of Alaska Anchorage (UAA)
1994-present Affiliate faculty, Dept. of Pathology, University of Washington School of Medicine, Seattle, WA
1991-1997 Assistant Professor, Biomedical Program & Dept. of Biological Sciences, UAA

REPRESENTATIVE PUBLICATIONS
:

Williams, K. DNA Damage Response Genes. In: Schwab M. (Ed.) Encyclopedia of Cancer: SpringerReference (www.springerreference.com). Springer-Verlag Berlin Heidelberg, 2012. DOI: 10.1007/SpringerReference_173167 2012-05-08 09:29:38 UTC

Edelbrock, M., Kaliyaperumal S., and Williams, K.J. (2013) Structural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activitiesMutat Res 743–744, 53–66.

Williams, K.J. and Sobol, R.W. (2013)  Mutation research/fundamental and molecular mechanisms of mutagenesis. Mutat Res 743– 744, 1-3. 

Blomquist, T.M., Brown, R.D., Crawford, E.L., de la Serna, I., Williams, K., Yoon, Y., Hernandez, D-A., and Willey, J.C. (2013) CEBPG Exhibits Allele-Specific Expression in Human Bronchial Epithelial Cells. Gene Regul Syst Bio 7, 125-138.

Gupte, M., Tuck, A.N., Sharma, V.P. and Williams, K.J.(2013) Major differences between tumor and normal human cell fates after exposure to chemotherapeutic monofunctional alkylator. PLoS One 8 (9). E74071.

Kaliyaperumal, S., Patrick, S.M., Williams, K.J. (2011) Phosphorylated hMSH6: DNA mismatch versus DNA damage recognition.  Mutat Res 706:36-45.

Mueser, T.C., Hinerman, J.M., Devos, J.M., and Williams, K.J. (2010) Structural analysis of bacteriophage T4 DNA replication: a review in the Virology Journal series on bacteriophage T4 and its relatives.Virol J 7:359.

Mueser, T.C., Williams, K.J. (2011) Alkylation chemotherapy: Mechanistic potential and pitfalls.  In: Advances in Genetics Research (K.V. Urbano, ed.), Nova Science Publishers, pp. 179-196.

Schroering, A., Kothandapani, A., Patrick, S.M., Kaliyaperumal, S., Sharma, V.P., Williams, K.J. (2009) Prolonged cell cycle response of HeLa cells to low-level alkylation exposure.  Cancer Res 69:6307-6314.

Edelbrock, M.A., Kaliyaperumal, S., Williams, K.J. (2009) DNA mismatch repair efficiency and fidelity are elevated during DNA synthesis in human cells.  Mutat Res 662:59-66.

Schroering, A., Williams, K.J. (2008) Rapid induction of chromatin-associated DNA mismatch repair proteins after MNNG treatment. DNA Repair 7:951-969.

Schroering, A., Edelbrock, M.A., Richards, T.J., Williams, K.J. (2007) The cell cycle and DNA mismatch repair.  Exp Cell Res 313:292-304.


Last Updated: 3/22/16