Biochemistry & Cancer Biology

News & Announcements 

Manning Paper 2nd Most Highly Cited Publication in Journal of Neuroendocrinology


Dr. Manning recently received a letter from Dr. Tehmina Amin, Managing Editor, Journal of Neuroendocrinology, notifying him and his co-authors that their paper*, with 16 citations, was the second most highly cited paper in the journal in 2013.

*Manning, M., Misicka, A., Olma, A., Bankowski, K., Stoev, S., Chini, B., Duroux, T., Mouillac, B., Corbani, M., and Guillon, G. (2012) Oxytocin and Vasopressin Agonists and Antagonists as Research Tools and Potential Therapeutics. J. Neuroendocrinol., 24:609-628.


Cancer Biology Students Receive Travel Awards


Congratulations to Cancer Biology students, Shweta Aras and Archit Trivedi, recipients of two travels awards to the 2014 International Pigment Cell Conference to be held in Singapore, Malaysia, Sept. 4-7, 2014.  They both were awarded $1,000 each from the International Federation of Pigment Cell Society and $600 each from the PanAmerican Society for Pigment Cell Research. 

sa Shweta will present an oral presentation on her work entitled "To Investigate the Role of Baf60a in Melanocyte Differentiation"
at Archit will present a poster on his work entitled "The Role of BRD4 in Melanogenesis"

Both students are mentored by Dr. Ivana de la Serna

Cancer Biology Student Articles Published in the Toledo Blade


The Toledo Blade is publishing a  series of articles written by Biomedical Sciences students here at the University of Toledo College of Medicine & Life Sciences.  Following are the first two in the series by our Cancer Biology students:

Shweta Aras (2/2/15) - Shining a light on the darkness of melanoma

Ila Datar (10/13/14) - The ongoing battle against melanoma

Akshada Sawant (5/5/14) - UT doctoral students fight to tame cancer genes

Jessica Arden (6/2/14) - Stopping cell movement in glioblastoma


 


jaJessica Arden


Cancer Biology Student Finalists in 2014 Graduate Research Forum
 

Congratulations to Cancer Biology students Nneka Mbah, Gaurav Mehta and Meghan Wyse for their wins at the 2014 Graduate Research Forum.  A total of 38 students participated from all four Biomedical Sciences tracks and the College of Pharmacy.  Each winner went through 2-3 rounds of screening to win their awards. 

mbah                              gm                                 wyse
Nneka Mbah (Maltese lab)                   Gaurav Mehta (de la Serna lab)               Meghan Wyse (Eisenmann lab)
1st Place Poster Presentation               1st Place Oral Presentation                     2nd Place Oral Presentation
   

Congratulations to Cancer Biology student, Nneka Mbah

 
Congratulations to Nneka Mbah (Maltese lab) for winning 3rd place in the Oral Presentation category at the Graduate Student Association 5th Annual Midwest Graduate Research Symposium held March 29, 2014.  The symposium has been recognized as a premier event and offers great opportunities for student to present their research, networking, and fostering intercollegiate friendships and collaborations. 

Ms. Mbah also received a $1,500 Millennium Scholar-in-Training award from the American Association for Cancer Research.  The award provides financial support for AACR meeting attendance to offset expenses incurred attending the program.  Nneka  presented a poster at the AACR annual meeting (San Diego, April 5-9) entitled "Non-apoptotic death induced in glioma cells by the indole-based chalcone, MOMIPP, involves disruption of endolysosomal trafficking and ER stress" (N.E. Mbah, A.D. Trunk, B.A. Dewitt, J.H. Overmeyer and W.A. Maltese).
mbah
   

Dr. de la Serna Receives Research Award from Melanoma Know More
 
Congratulations to Dr. Ivana de la Serna on receiving the 2013 Melanoma Know More research grant for her research on the role of epigenetic regulators in melanocyte development.  Melanoma Know More is a Cincinnati-based, grass-roots organization that was formed in 2006 to generate awareness and education about melanoma and the importance of early detection and prevention.   mkm
   
Biochemistry & Cancer Biology Faculty Receive 2013 Deans Awards  

Congratulations to Dr. Kathryn Eisenmann and Dr. Cynthia Smas on receiving 2013 Dean Awards for research and teaching. 

Dr. Eisenmann was selected as the recipient of a 2013 College of Medicine & Life Sciences Dean's Award for Research in the New Investigator category.  Dr. Smas received the 2013 College of Medicine & Life Sciences Dean's Award for Teaching Excellence in Basic Sciences.  Both were strongly support by their chair, peers and by student representatives for these awards.  They were honored at the University of Toledo College of Medicine & Life Sciences Faculty Recognition Reception held on October 10. 

(photo courtesy of Dr. Maurice Manning)

awards
   

Life-Saving compound developed and patented at UToledo licensed to Prolong Pharmaceuticals

A compound developed at The University of Toledo that can be used to prevent blood vessels from leaking fluid into surrounding tissue following a traumatic injury to the human body has been licensed to Prolong Pharmaceuticals LLC, South Plainfield, NJ, for continued development and commercialization.

The invention uses polyethylene-glycol (PEG) to modify albumin, a protein found in blood, to expand the blood’s volume and prevent it from escaping through holes in blood vessels.

“The University of Toledo is proud of our role in developing this technology that has the potential to save lives and limit the internal fluid leakage that can lead to multi-organ dysfunction and failure, and even death,” UT President Dr. Lloyd Jacobs said. “This technology is an example of the great contribution the science developed and patented at The University of Toledo can have on people around the globe.”

The technology – developed by Dr. Ragheb Assaly, professor of medicine, Dr. David Dignam, professor of biochemistry and Dr. Joseph Shapiro a former professor of nephrology and now dean of the Marshall University medical school – promises to become the optimal blood volume expander to prevent decreased blood volume caused by severe burns, hemorrhagic shock, sepsis, anaphylaxis, traumatic brain injury, adult respiratory distress syndrome and other traumatic injuries.

PEG-albumin has been tested in animal models and in all cases has demonstrated superiority to regular albumin as a plasma expander.

“The university is excited to enter into this license with Prolong Pharmaceuticals for the development and commercialization of this technology,” said Stephen Snider, vice president of technology transfer and associate general counsel. “This collaboration with Prolong will serve to bring this life-saving treatment to patients and further UT’s mission to improve the human condition.”

Prolong Pharmaceuticals is developing products to treat several diseases and their debilitating co-morbidities that reduce quality of life and increase medical cost and mortality.

For more information, go to prolongpharma.com

   
Cover image of August 2013 issue of The Journal of Pharmacology and Experimental Therapeutics jpet
The Journal of Pharmacology and Experimental Therapeutics chose to highlight a structural homology model of a monomeric mouse oxytocin receptor on their August 2013 cover.  The figure was published from the article "Selective and Potent Agonist and Antagonists for Investiging the Role of Mouse Oxytocin Receptors" by M. Busnelli, E. Bulgheroni, M. Manning, G. Kleinau, and B. Chini (pp. 381-327).
   

Dr. Manning named UT COM Student Ombudsman

  manning

 

An Ombudsman is generally defined as a representative of an organization whose position is designed to investigate complaints and suggest solutions.  Within a university, the Ombuds helps students resolve concerns, problems or conflicts with regards to university policies, procedures and decisions.   The Ombuds will provide a confidential and neutral place for students to come to express their concerns and work to identify options for a successful resolution of their problem.  This does not take the place of other formal processes, but acts as an additional option to guide conflict resolution.

The University of Toledo College of Medicine and Life Sciences is happy to announce that Maurice Manning, Ph.D., D.Sc. has agreed to serve as the Ombuds for the College of Medicine and Life Sciences.  Dr. Manning is a Distinguished University Professor in the Department of Biochemistry and Cancer Biology.  He has been widely recognized for his excellence in teaching having received the Deans Award for Teaching Excellence and 13 Golden Apple Teaching Awards.  He is also a renowned researcher whose work on peptide ligands for vasopressin and oxytocin receptors has contributed significantly to the scientific literature.   Many of these peptides have been utilized as research tools in laboratories worldwide and have helped to advance continuing research in the oxytocin vasopressin field.   In addition to his teaching and research excellence, he has been an outstanding mentor to many students through the years.  It is his true caring for his students and the University that makes him an excellent person to be our Ombuds.  Dr. Manning can be reached at (419) 383-4143 for appointments.

University of Toledo WIRED Newsletter, March 26, 2013

Biochemistry & Cancer Biology department research highlighted

A recent Rocket Science publication highlights research by several members of the Department of Biochemistry & Cancer Biology.  This includes articles describing the research of Dr. Kam Yeung on the function of the RKIP protein in slowing the growth and spread of cancer cells; Dr. Ivana de la Serna on the role of modifications of chromatin structure for cancer treatment; Drs. Kandace Williams and Steve Patrick exploring how DNA repair pathways may be exploited to boost effectiveness of cancer therapies; Dr. Manohar Ratnam on development of new therapies for breast and prostate cancers; and that of department chair, Dr. William Maltese, on gene-based strategies to kill glioblastoma cells.

rocketscience

 

Congratulations to Cancer Biology students

arden
Arden

Congratulations to Jessica Arden and Kari Lavik (Eisenmann lab) on receiving $300 student travel awards from The American Society of Cell Biology.  Both students will present posters at the 2013 annual meeting in New Orleans, December 2013.

Jessica Arden and Kathryn Eisenmann - "The Role of mDia Formins in Rho-Directed Glioblastoma Invasion"

Kari Lavik and Kathryn Eisenmann - "A Collaborative Role for Neuronal-Wiskott Aldrich Syndrome Protein (N-WASp) and Mammalian Diaphanous-Related (MDia) Formins during Stage 1 Invadopodia Formation"

 
lavik
Lavik


Dr. Ivana de la Serna
's students presented their work at the 2013 PASPCR annual meeting held at the Univ. of Wisconson-Madison, September 8-11, 2013.  Shweta Aras, Gaurav Mehta, and Archit Trivedi all received $500 travel awards.  Congratulations!

S. Aras and I. de la Serna - Role of SWI/SNF Enzymes in the Repair of UV-induced DNA Damage

G. Mehta and I. de la Serna - Protein Arginine N-methyltransferase-5 (PRMT5) in Melanocyte Differentiation

A.R. Trivedi, A. Mehrotra, H.G. Marathe, I.L. de la Serna - PABF Chromatin Remodeling Complexes Promote p53 Target Gene Expression in Response to Ultraviolet Radiation

H. Marathe and I. de la Serna - Synergistic Activation of Melanocyte Specific Gene Expression by MITF and SOX10 Involves Recruitment of SWI/SNF Chromatin Remodeling Enzymes

SA                                   gm                                   at
         Aras                                                         Mehta                                                            Trivedi

mbah

Congratulations to Cancer Biology track students, Nneka Mbah and Kaitlyn Dvorak on their election to the board of the University of Toledo Council of Biomedical Graduate Students (CBGS) for the 2013-2014 school year!

Board Secretary - Nneka Mbah, 3rd year
Cancer Biology Representative - Kaitlyn Dvorak, 2nd year

 kd
mehta

Congratulations to Gaurav Mehta for winning first prize for his oral presentation entitled "SWI/SF Chromatin Remodeling Enzymes in Transcriptional Regulation of Pathological Cardiac Hypertrophy," co-authored by Jian Wu and Dr. Ivana de la Serna, at the 40th Annual Pharmacology Research Colloquium, June 7, 2013, at Wayne State University.  Mr. Mehta placed first out of thirteen oral presentations.  The colloquium was attended by students, faculty and staff from Michigan State University, University of Michigan, University of Toledo, and Wayne State University.  Gaurav is mentored by Dr. Ivana de la Serna.

nm Congratulations to Cancer Biology track student, Nneka Mbah (3rd year) on her election as Secretary to the board of the University of Toledo Council of Biomedical Graduate Students (CBGS) and to Shweta Aras (4th year) as the Cancer Biology Representative for the 2013-2014 school year! aras
Mbah   Aras
Kari Lavik

Kari Lavik, member of the Dr. Kathryn Eisenmann's lab, has been awarded the 2013 MGRS AWIS (Association for Women in Science) Award for the top woman in a STEM field.

Kari Lavik received 2nd Place for Oral Presentation at the 2013 Midwest Graduate Research Symposium, The University of Toledo, Toledo, OH held April 20, 2013,  organized by the Graduate Students Association (GSA).
Title of Presentation:  "A Collaborataive Role for N-WASP and mDia Formins during Stage 1 and 2 of Invadopodia Formation".  Congratulations Kari!

Gaurav Mehta

Gaurav Mehta, member of the Dr. Ivana de la Serna’s lab, took 1st place for oral presentation at the 2013 Midwest Graduate Research Symposium, The University of Toledo, Toledo, OH held on April 20, 2013.  The event was organized by the Graduate Students Association (GSA). 
Title of Presentation:  "SWI/SNF Chromatin Remodeling Enzymes in Transcriptional Regulation of Pathological Cardiac Hypertrophy".  Congratulations Gaurav!

wyse

Meghan Wyse, member of the Dr. Kathryn Eisenmann's lab, took 2nd Place for Oral Presentation at the 2013 Graduate Research Forum, The University of Toledo College of Medicine, Toledo, OH on March 22, 2013.  Total of 52 students participated from all four tracks in the Biomedical Science Program and College of Pharmacy in the Graduate Research Forum 2013.  Congratulations Meghan!

mbah

Nneka Mbah, member of the William Maltese and Jean Overmeyer lab, has been awarded the 2013 Robert R. Buell Memorial Achievement Award.  The award recognizes a graduate student who best exemplifies comprehensive excellence in the physical, biological and social sciences, and in the humanities and plans a career in education. Nneka is currently a third year biomedical sciences student in the Cancer Biology track investigating the relationship between energy metabolism and cell death in glioblastoma cells underoing methuosis.  Congratulations Nneka!

Archit Trivedi

Archit Trivedi, 2nd year Cancer Biology graduate student, took second place at the Univ. of Toledo Midwest Graduate Research Symposium held March 24, 2012.  The symposium was organized by the UT Graduate Student Association and featured presentations from graduate students represented by 25 invited midwestern universities.  This is the first time a student from the Health Science campus has won an award at the symposium. 

Mr. Trivedi is a second-year PhD student in Dr. Ivana de la Serna’s lab.  The title of his presentation was, “BRG1 cooperates with MITF to promote melanoma survival”.  Co-authors were Srinivas Vinod Saladi (Cancer Biology alumni) and Dr. de la Serna.  Congratulations Archit on a great accomplishment!

Arden

Jessica Arden, Dr. Kathryn Eisenmann's lab, has received the 2011/2012 Satellites and Retirees Scholarship award for the Cancer Biology track of the Biomedical Sciences program.  Jessica is a MD/PhD student and has completed her first two years of medical school and recently passed her Step 1 exams.  She is currently a full-time student in the Eisenmann lab investigating the role formins play in directing the aggressive type of brain cancer cells, glioblastoma, to spread within the normal brain tissue.  Congratulations Jess!

 

2014 Thesis Defense

as CONGRATULATIONS to Akshada Sawant, Ph.D.!
Dr. Sawant successfully defended her dissertation entitled "Role of Base Excision Repair and Mismatch Repair Proteins in the Processing of Cisplatin Interstrand Cross-Links" on June 19, 2014.  She has been mentored by Dr. Steve Patrick.  Dr. Sawant has accepted a postdoctoral fellowship at Wayne State University, Karmanos Cancer Center.
mw CONGRATULATIONS to Meghan Wyse, Ph.D.!
Dr. Wyse successfully defended her dissertation entitled "CXCL12 Mediated Regulation of the Cytoskeletal Regulator mDia2 Formin Induces Amoeboid Conversions and Cellular Plasticity in Migrating Human Breast Carcinoma Cells" on June 3, 2014.  She has been mentored by Dr. Kate Eisenmann.  Dr. Wyse has accepted a postdoctoral fellowship at UCSD.
ja CONGRATULATIONS to Jessica Arden, Ph.D.!
Dr. Arden successfully defended her dissertation entitled "Diaphanous-Related Formin Hyperactivation is Superior to its Inactivation as an Anti-Invasive Strategy for Glioblastoma" on May 29, 2014.  She has mentored by Dr. Kate Eisenmann.  Jess will return to medical school in July to complete years 3 and 4 to receive her M.D. degree.
 
2013 Thesis Defense

qd CONGRATULATIONS to Qiming Duan, Ph.D.!
Dr. Duan successfully defended his dissertation entitled "Cardiac Na/K-ATPase in Ischemia-Reperfusion Injury and Cardioprotectoin" on December 20, 2013.  Qiming has been mentored by Dr. Sandrine Pierre and has accepted a Postdoctoral Fellowship at Case Western Reserve University, Cleveland, OH.
chari CONGRATULATIONS to Venkatesh Chari, Ph.D.!
Dr. Chari successfully defended his dissertation entitled "Drug Targets to Improve the Outcome of Hormonal Adjuvant Therapy in Breast and Prostate Cancers" on November 12, 2013.  Venky has been mentored by Dr. Manohar Ratnam and has accepted a position as Staff Scientist at Life Technologies, San Francisco, CA.
wu

CONGRATULATIONS to Jian Wu, Ph.D.!
Dr. Wu successfully defended his dissertation entitled "Role of Phosphoinositide 3-Kinase alpha (PI3Kalpha) in Ouabain-Induced Cardiac Signaling and Hypertrophy" on November 1, 2013.  Jian has been mentored by Dr. Lijun Liu.  He has accepted a Postdoctoral Fellowship at the University of Southern California, Los Angeles, CA.

patki CONGRATULATIONS to Mugdha Patki, Ph.D.!
Dr. Patki successfully defended her dissertation entitled "Novel Actions of Steroid Receptors that Limit Treatment Response in Breast and Lung Cancers" on October 2, 2013.  Mugdha has been mentored by Dr. Manohar Ratnam and will continue in her research in his lab for an additional year as a post-doctoral fellow at the Karmanos Cancer Institute, Detroit, MI.
robinson CONGRATULATIONS to Michael Robinson, Ph.D.!
Dr. Robinson successfully defended his dissertation entitled "Synthesis and Evaluation of Inducers of Methuotic Cell Death and Preliminary Identification of their Cellular Targets in Glioblastoma Cells" on June 14, 2013.  He has mentored by Dr. William Maltese and Dr. Paul Erhardt.  Mike will return to medical school next month to complete years 3 and 4 to receive his M.D. degree.
Marathe CONGRATULATIONS to Himangi Marathe, Ph.D.
Dr. Marathe successfully defended her dissertation entitled "SWI/SNF Chromatin Remodeling Enzymes as Regulators of Neural-crest Derived Cell Differentiation" on June 10, 2013.  Himangi also received the 2012 Biomedical Sciences Program Outstanding Student award at graduation ceremonies.  Dr. Marathe has been mentored by Dr. Ivana de la Serna.  She has accepted a Postdoctoral Fellowship at St. Jude Children's Research Hospital, Memphis, TN.
 

 
2006-2012 Biochemistry & Cancer Biology graduates




 










 

Last Updated: 3/22/15