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Health Science Campus
Health Education Building & Center for Creative Education Building
BPG Computer Classroom: HEB 1st Floor, Room #127
Genomic Core Lab: HEB 2nd Floor, Room #200
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David A. Weaver, DDS, PhD
University of Toledo Health Science Campus
Dept. of Public Health and Preventive Medicine
Health Education Building, Room 200
3000 Arlington Avenue
Toledo, OH 43614
My research interests are in the fields of carcinogenesis, mutagenesis and gene expression. I am currently the Director of the Genomics Core Laboratory, which is a center for performing high-tech analysis of gene expression in prokaryotic and eukaryotic prepared specimens utilizing microarray technology.
Recent Selected Publications:
Vondracek, M., Weaver, D.A., Sarang, Z., Hedberg, J.J., Willey, J.C., Wärngård, L. and Grafström, R.C., Transcript profiling of enzymes involved in detoxification of xenobiotics and reactive oxygen in human normal and simian virus 40 T antigen-immortalized oral keratinocytes, Int J Cancer 99(6), 776-782, 2002.
Crawford, E.L., Peters, G.J., Noordhuis, P., Rots, M.G., Vondracek, M., Grafström, R.C., Lieuallen, K., Lennon, G., Zahorchak, R.J., Georgeson, M.J., Wali, A., Lechner, J.F., Fan, P.S., Kahaleh, M.B., Khuder, S.A., Warner, K.A., Weaver, D.A., and Willey, J.C., Reproducible gene expression measurement among multiple laboratories obtained in a blinded study using standardized RT (StaRT)-PCR, Mol Diagn 6(4), 217-225, 2001.
Crawford, E.L., Warner, K.A., Weaver, D.A., and Willey, J.C., Quantitative end-point RT-PCR gene expression measurement using the Agilent 2100 Bioanalyzer and standardized RT-PCR, Agilent Technologies Technical Application Note, 2001.
Willey, J.C., Crawford, E.L., Olson, D.E., Hammersley, J.R., Jennings, C.A., Weaver, D.A., Utell, M.J., Frampton, M.W. and Durham, S.J., Expression measurement of genes related to cancer susceptibility in human bronchial epithelial cells, In Relationships between acute and chronic effects of air pollution, (eds) U. Heinrich and U. Mohr, International Life Sciences Press, Washington, D.C., 79-96, 2000.
Crawford, E.L., Khuder, S.A., Durham, S.J., Frampton, M., Utell, M., Thilly, W.G., Weaver, D.A., Ferencak, W.J., Jennings, C.A., Hammersley, J.R., Olson, D.E. and Willey, J.C., Normal bronchial epithelial cell expression of glutathione transferase P1, glutathione transferase M3, and glutathione peroxidase is low in subjects with bronchogenic carcinoma, Cancer Res 60(6), 1609-1618, 2000.
Weaver, D.A., Hei, T.K., Hukku, B., DeMuth, J.P., Crawford, E.L., McRaven, J.A., Girgis, S. and Willey, J.C., Localization of tumor suppressor gene candidates by cytogenetic and short tandem repeat analyses in tumorigenic human bronchial epithelial cells, Carcinogenesis 21(2), 205-211, 2000.
Crawford, E.L., Weaver, D.A., DeMuth, J.P., Jackson, C.M., Khuder, S.A., Frampton, M.W., Utell, M.J., Thilly, W.G. and Willey, J.C., Measurement of cytochrome P450 2A6 and 2E1 gene expression in primary human bronchial epithelial cells, Carcinogenesis 19(10), 1867-1871, 1998.
Willey, J.C., Crawford, E.L., Jackson, C.M., Weaver, D.A., Hoban, J.C., Khuder, S.A. and DeMuth, J.P., Expression measurement of many genes simultaneously by quantitative RT-PCR using standardized mixtures of competitive templates, Am J Respir Cell Mol Biol 19(1), 6-17, 1998.
DeMuth, J.P., Jackson, C.M., Weaver, D.A., Crawford, E.L., Durzinsky, D.S., Durham, S.J., Zaher, A., Phillips, E.R., Khuder, S.A. and Willey, J.C., The gene expression index c-myc x E2F-1/p21 is highly predictive of malignant phenotype in human bronchial epithelial cells, Am J Respir Cell Mol Biol 19(1), 18-24, 1998.
DeMuth, J.P., Weaver, D.A., Crawford, E.L., Jackson, C.M. and Willey, J.C., Loss of spr1 expression measurable by quantitative RT-PCR in human bronchogenic carcinoma cell lines, Am J Respir Cell Mol Biol 19(1), 25-29, 1998.
Weaver, D.A., Hei, T.K., Hukku, B., McRaven, J.A. and Willey, J.C., Cytogenetic and molecular genetic analysis of tumorigenic human bronchial epithelial cells induced by radon alpha particles, Carcinogenesis 18(6), 1251-1257, 1997.
Click for full Curriculum Vitae (pdf file)