to the 23rd Annual International CEA Symposium
Held on August 15 – 18, 2013
at the Park Inn hotel located in the historic downtown Toledo, Ohio, USA
The 23rdAnnual International CEA Symposium is set up following the tradition of the CEA meetings to share new insights on the function and regulation of CEA genes. Several new scientists will join (from India, Japan, Qatar and the US), and newly discovered role for CEACAM in mediating GLP1-regulation of insulin secretion, hepatic fibrosis, atherosclerosis, hypertension and thrombosis, in addition to angiogenesis, cancer and immunity will be discussed. The multifunctional aspect of CEACAM proteins necessitates rapid dissemination of new findings, which can only be achieved through scientific exchanges at the CEA Symposia. Exciting novel discoveries from affiliated laboratories in the last year pave the way to make the 2013 Symposium an outstanding platform for sharing and learning.
Since its discovery in 1965, the Carcinoembryonic antigen (CEA) has been used as an important diagnostic and prognostic marker of tumor progression in several epithelial tumors. In the last couple of decades, about 28 genes/pseudo genes that are structurally related to CEA have been identified. These are composed of the CEA (carcinoembryonic antigen) and the PSG (pregnancy-specific glycoprotein) molecules. Members of this family are termed CEA-related cell adhesion molecules (CEACAMs). In addition to their cell adhesion function, CEA proteins regulate diverse cellular processes: cell proliferation and differentiation, as well as cell death. Several independent animal and cell-based studies have indicated that these proteins regulate tumor progression, immune cell activation, insulin metabolism and action, and the development of new blood vessels. Moreover, some of these proteins serve as receptors for different pathogens.
Since 1990, the Annual CEA Symposium has been held in Europe and North America. These regular symposia allow clinical as well as basic scientists with shared interest in CEACAM and PSG proteins and related diseases, to get together to discuss the functions of this family of proteins from different physiological and mechanistic perspectives, and to generate multifaceted collaborations. The symposia have also provided an extraordinary platform to attract new scientists from all over the Globe, including Australia, Asia, Canada, Europe, the Middle East and the United States. In keeping with the multifaceted functions of these proteins, we will discuss their role in metabolism (obesity, dyslipidemia, diabetes, fatty liver disease), cardiovascular diseases (atherosclerosis, thrombosis, hypertension and left ventricular hypertrophy); inflammatory disease (small bowel inflammatory disease), common types of cancer, angiogenesis, reproduction and others.
Active participants, interested in the progress of CEA research are welcome. Young scientists as well as group leaders are invited. As in Gordon Research Conferences, predominantly unpublished data will be presented and discussed. This provides a unique opportunity for scientists from divergent backgrounds to integrate their knowledge with an overarching goal to promote our understanding of the pathogenesis of CEA-related human diseases.
Abstracts Due date
Abstracts are being accepted now