The University of Toledo

CeDER PUBLICATIONS

All publications since inception of CeDER in 2006 or since joining CeDER

Brent D. Cameron, PhD.

Rui Zheng, Byung-Wook Park, Dong-Shik Kim, Brent D. Cameron. Development of a highly specific amine-terminated aptamer functionalized surface plasmon resonance biosensor for blood protein detection. Optical Society of America: Biomedical Optics Express. 2011 Sep 1;2(9):2731-40. Epub 2011 Aug 31. PMCID:PMC3184881


Raymond E. Bourey, MD. Since joining CeDER in 2007

Ghosh S, M. Kaw, P. R. Patel, K. J. Ledford, T. A. Bowman, M. F. McInerney, S. K. Erickson, R. E. Bourey, S. M. Najjar. Mice with null mutation of Ceacam1 develop nonalchoholic steatohepatitis. Hepatic Medicine: Evidence and Research. 2010 May;2010(2):69-78. PMCID:PMC3177946

Bourey, R. E. Primary menopausal insomnia - definition, review, and practical approach. Endocrine practice. 2011 Jan-Feb;17(1):122-31. PMID: 20713350

Bourey, R. E., J. R. Bourey, N. Habbal, and A. Balaa. Early gain in body mass with continuous positive aiway pressure therapy for obstructive sleep apnea. Somnologie. 2009 Nov;19(11):1472-6. Epub 2009 Aug 25. PMID: 19705206

Bowman, T. A., M. Kaw, S. J. Lee, P. R. Patel, R. E. Bourey, P. M. Haram, L. G. Koch, S. L. Britton, U. Wisløff, A. D. Lee, S. M. Najjar. Caloric restriction reverses hepatic insulin resistance and steatosis in rats with low aerobic capacity. Endocrinology. 2010 Nov;151(11):5157-64. Epub 2010 Sep 22. PMCID:PMC2954714

Pappada S.M., B. D. Cameron, R. E. Bourey, M. J. Borst, D. M. Shipp, J. D. Lather, T. J. Sbrocchi. Neural Network Based Real-time Prediction of Glucose in Patients with Insulin Dependent Diabetes. Diabetes Technology and Therapeutics. 2011 Feb;13(2):135-41. PMID: 21284480

Pappada SM, Borst MJ, Cameron BD, Bourey RE, Lather JD, Shipp D, Chiricolo A, Papadimos TJ. Development of a neural network model for predicting glucose levels in a surgical critical care setting. Patient Saf Surg. 2010 Sep 9;4(1):15. PMID: 20828400

Bourey, R.E. and C. P. Lambert. Drug Treatment of Obesity. In: Angelopoulos, T. and J. Rippe. Obesity: Prevention and treatment. CRC Press, Boca Raton. 2012 (In Press)


Khew_Voon Chin, PhD.

Saunders RA, Fujii K, Alabanza L, Ravatn R, Kita T, Kudoh K, et al. Altered phospholipid transfer protein gene expression and serum lipid profile by topotecan. Biochem Pharmacol. 2010; 80(3):362-9. PMCID: PMC2883626.

Wu Q, Saunders RA, Szkudlarek-Mikho M, Serna ID, Chin KV. The obesity-associated Fto gene is a transcriptional coactivator. Biochem Biophys Res Commun. 2010 Oct 22;401(3):390-5. Epub 2010 Sep 19. PMCID:PMC2963669

Kablan A, Saunders RA, Szkudlaek M, Chin AJB, Bosio RM, Fujii K, Shapiro J, Chin KV. Prieurianin causes weight loss in diet-induced obese mice and inhibits adipogenesis in cultured preadipocytes. J Diabet Metabol 2010 Sep 29;1(101). pii: 1000101. PMCID: PMC3093537

Shao, Q., and Chin, K.V. A survey of the American food trends and the growing obesity epidemic. Nutr Res Prac. 2011 Jun;5(3):253-9. Epub 2011 Jun 21. PMCID: PMC3133759

Liang L, Chen J, Vittal R, Selvanayagam ZE, McAteer JA, Deng L, et al. Expression profiling of crystalinduced injury in human kidney epithelial cells. Nephron Physiol. 2006;103(1):p53-62. Epub 2005 Dec 21. PMID: 16374038

Liao JG, Chin KV. Logistic regression for disease classification using microarray data: model selection in a large p and small n case. Bioinformatics. 2007 Aug 1;23(15):1945-51. Epub 2007 May 31. PMID: 17540680

El-Okdi N, Smaili S, Raju V, Shidyak A, Gupta S, Fedorova L, et al. Effects of cardiotonic steroids on dermal collagen synthesis and wound healing. J Appl Physiol. 2008;105(1):30-6. PMCID: PMC2494826.

Szkudlarek M, Bosio RM, Wu Q, Chin KV. Inhibition of angiogenesis by extracellular protein kinase A. Cancer Lett. 2009;283(1):68-73. PMCID: PMC2713806.

Yang WL, Ravatn R, Kudoh K, Alabanza L, Chin KV. Interaction of the regulatory subunit of the cAMPdependent protein kinase with PATZ1 (ZNF278). Biochem Biophys Res Commun. 2010; 391(3):1318-23. PMCID: PMC2812659.

Saunders, R.A., Fuji, K., Alabanza, L., Ravatn, R., Kita, T., Kudoh, K., and Chin, K.V. “Altered phospholipid transfer protein gene expression and serum profile by topotecan”, Biochem. Pharmacol., 80:362-369, 2010.

Wu, Q., Saunders, R.A., de la Serna, I., and Chin, K.V. “The obesity-associated Fto gene is a transcriptional coactivator”, Biochem. Biophy. Res. Commun., 401:390-395, 2010.

Kablan, A., Saunders, R.A., Szkudlarek, M., Chin, A.J.B., Bosio, R.M., Fujii, K., Shapiro, J., Chin, K.V. “Prieurianin causes weight loss in diet-induced obese mice and inhibits adipogenesis in cultured preadipocytes”, J. Diabet. Metabol., 1:101, 2010.

Saladi, S.V., Keenen, B., Marathe, H.G., Qi, H., Chin, K.V., de la Serna, I.L. “Modulation of extracellular matrix/adhesion molecule expression by BRG1 is associated with increased melanoma invasiveness”, Mol. Cancer, 9:280, 2010.

Shao, Q., and Chin, K.V. “Survey of American food trends and the growing obesity epidemic”, Nutr. Res. Prac., 5:253-259, 2011.

Szkudlarek-Mikho, M., Saunders, R.A., Yap, S.F., Ngeow, Y.F., Chin, K.V. “Salinomycin, a polyether antibiotic, inhibits adipogenesis”, Biochem. Biophys. Res. Commun. 428:487-493, 2012.


Joan R. Griffith, MD. Since joining CeDER in 2006

Ramirez, I, Griffith JR, Watkins M. “Bilateral Lower Extremity Edema in a 14 Year Old Female: A Case Report.” Accept Consultant for Pediatricians May 2009.

King JT, Hall J, Griffith JR, Mullineaux DR, Clasey JL. “Comparison of body composition from the Bod Pod S/T”. International Journal of Body Composition Research.2009;7:41-48.

Griffith JR, Assessing Childhood Obesity Program in Low-Socioeconomic and Diverse Communities. JNMA. 2009 May;101(5):421-9. PMID: 19476195

Griffith JR, Clasey JL, King JT, Gantz S, Kryscio RJ, Bada HS. Role of parents in determining children’s physical activity. World J Pediatr. 2007;3(4):265-270

Griffith JR, Gantz S, Lowry J, Dai H, Bada H. Insurance Reimbursement in a University-Based Pediatric Weight Management Clinic. JNMA. 2007 Sep;99(9):1037-41. PMID: 17913114

Griffith JR, Bada S. Chiari I Malformation: Patient report and a mini review. Clinical Pediatrics. 2006 Jul;45(6):570-3. PMID: 16893864


Jennifer W. Hill, PhD Since joining CeDER on July 1, 2009

Marino JS, Hinds TD, Hoover R, Ondrus E, Onion JL, Dowling A, McLoughlin TJ, Hill JW Suppression of Protein Kinase C Theta Contributes to Enhanced Myogenesis in vitro via IRS1 and ERK1/2 phosphorylation. BMC Cell Biology Accepted.

Hill, JW, Alreja M., Elias CF. From precocious puberty to infertility: metabolic control of the reproductive function (invited review) Frontiers in Systems and Translational Endocrinology. March 2013 PMID: 23565110

Qiu, X., Dowling, A., Marino J., Faulkner L., Brüning, J., Elias, CF, Bryant B., Hill, JW Delayed Puberty but Normal Fertility in Mice with Selective Deletion of Insulin Receptor from Kiss1 Cells, Endocrinology. 2013 Mar;154(3):1337-48 PMID: 23392256

Hill, JW. PVH Pathways Controlling Energy Homeostasis. (Invited Review) Indian Journal of Endocrinology and Metabolism. 2012 Dec;16(Suppl 3):S627-36. PMID: 23565499

Xu Y, Faulkner L., Hill, JW. Cross-talk between metabolism and reproduction: The Role of POMC and SF-1 Neurons. (Invited Review) Frontiers in Systems and Translational Endocrinology 2012 January 4.

Marino JS, Iler J, Dowling AR, Chua S, Bruning JC, Coppari R, Hill JW. Adipocyte Dysfunction in a Mouse Model of Polycystic Ovary Syndrome (PCOS): Evidence of Adipocyte Hypertrophy and Tissue-Specific Inflammation. PLoS One. 2012;7(10):e48643. PMID: 23119079

Marino JS, Peterson SJ, Li M, Vanella L, Sodhi K, Hill JW, Abraham NG. ApoA-1 mimetic restores adiponectin expression and insulin sensitivity independent of changes in body weight in female obese mice. Nature Nutrition and Diabetes. 2012 March  2; e33.

Patel PR, Ramakrishnan SK, Kaw MK, Raphael CK, Ghosh S, Marino JS, Heinrich G, Lee SJ, Bourey RE, Hill JW, Jung DY, Morgan DA, Kim JK, Rahmouni SK, Najjar SM. Increased Metabolic Rate and Insulin Sensitivity in Male Mice Lacking the Carcinoembryonic Antigen-Related Cell Adhesion Molecule 2. Diabetologia. 2011 Dec 11. PMID: 22159884

Patel PR, Ramakrishnan SK, Kaw MK, Raphael CK, Ghosh S, Marino JS, Heinrich G, Lee SJ, Bourey RE, Hill JW, Jung DY, Morgan DA, Kim JK, Rahmouni SK, Najjar SM.  Increased Metabolic Rate and Insulin Sensitivity in Male Mice Lacking the Carcinoembryonic Antigen-Related Cell Adhesion Molecule 2. Diabetologia. 2011 Dec 11. PMID: 22159884

Joseph S. Marino, Yong Xu, Jennifer W. Hill. Central insulin and leptin-mediated autonomic control of glucose homeostasis. Trends Endo and Met. 2011 Jul;22(7):275-85. Epub 2011 Apr 12. PMID: 21489811

Xu Y, Hill JW (joint first author), Fukuda M, Gautron L, Sohn J, Kim K, Lee CE, Choi MJ, Lauzon D, Dhillon H, Lowell BB, Zigman JM, Zhao JJ, Elmquist JK. PI3K signalling in the ventromedial hypothalamus is required for normal energy homeostasis. Cell Metabolism. 2010 July 4;12(1), 88-95. PMID: 20620998

Hill JW, Elias CF, Fukuda M, Williams KW, Berglund ED, Holland WL, Cho Y, Chuang J, Xu Y, Choi M, Lauzon D, Lee CE, Coppari R, Richardson JA, Zigman JM, Chua S, Scherer PE, Lowell BB, Bruning JC, Elmquist JK. Direct Insulin and Leptin Action in Pro-opiomelanocortin Neurons is Required for Normal Glucose Homeostasis and Fertility. Cell Metabolism. 2010 Apr 7;11(4):286-97. PMID: 20374961

Hill JW. Gene Expression and the Control of Food Intake by Hypothalamic POMC/CART Neurons. The Open Neuroendocrinology Journal,  2010 January 3;21-27.

Hill JW, Yong X, Preitner F, Fukuda M, Cho Y, Luo J, Balthasar N, Coppari R, Cantley LC, Kahn B, Zhao JJ, Elmquist JK. Phosphatidyl Inositol 3-Kinase Signaling in Hypothalamic Proopiomelanocortin Neurons Contributes to the Regulation of Glucose Homeostasis. Endocrinology. 2009 Nov;150(11):4874-82. PMID: 19819947


Beata Lecka-Czernik, PhD Since joining CeDER in June 2007
 
Shockley, K.R., Rosen, C.J., Churchill, G.A., Lecka-Czernik, B. PPARγ2 Regulates a Molecular Signature of Marrow Mesenchymal Stem Cells. PPAR Res. 2007;2007:81219. PMCID:PMC2234088

Lecka-Czernik, B. Local and systemic functions of bone fat and its contribution to the energy metabolism – The effect of diabetes and obesity on bone. J Musculoskeletal and Neuronal Interactions. 2008 Oct-Dec;8(4):346-7. PMID: 19147970

Lecka-Czernik, B. Bone as an integral part of energy metabolism. J Musculoskeletal and Neuronal Interactions. 2008 Oct-Dec;8(4):344-5. PMID: 19147969

Ackert-Bicknell, C.L., Skockley, K.R., Horton, L.G., Lecka-Czernik, B., Churchill, G.A., Rosen, C.J. Strain specific effects of Rosiglitazone on bon mass, body composition and serum IGF-I. Endocrinology. 2009 Mar;150(3):1330-40. Epub 2008 Oct 23. PMCID:PMC2654751

Shockley, K.R., Lazarenko, O.P., Czernik, P.J., Rosen, C.J., Churchill, G.A., Lecka-Czernik, B. PPARg2 nuclear receptor controls multiple regulatory pathways of osteoblast differentiation from marrow mesenchymal stem cells. J Cell Biochem. 2009 Feb 1;106(2):232-46. PMCID:PMC2745312

Lecka-Czernik, B. Bone is a target for type 2 diabetes treatment. Current Opinion in Investigational Drugs. 2009 Oct;10(10):1085-90. PMID: 19777397

Huang, S., Kaw, M., Harris, M.T., Ebraheim, N., McInerney, M.F., Najjar, S.M., Lecka-Czernik, B. Decreased Osteoclastogenesis and High Bone Mass in Mice with Impaired Insulin Clearance Due to Liver-Specific Inactivation to CEACAM1. Bone. 2010 Apr;46(4):1138-45. Epub 2010 Jan 4. PMCID:PMC2862391

Lecka-Czernik, B. PPARs in Bone: The role in bone cell differentiation and regulation of energy metabolism. Curr Osteoporos Rep. 2010; 8(2):84-90. PMID: 20425615

Kawai M, Green CB, Horowitz M, Ackert-Bicknell C, Lecka-Czernik B, Rosen CJ. Nocturnin: a circadian target of Pparg-induced adipogenesis. Ann N Y Acad Sci. 2010 Mar;1192:131-8. PMID: 20392228

Lecka-Czernik, B. PPARg, an essential regulator of bone mass; Metabolic and molecular cues. IBMS BoneKEy. 2010;7:187-189.

Kawai M, Green CB, Lecka-Czernik B, Douris N, Gilbert MR, Kojima S, Ackert-Bicknell C, Garg N, Horowitz MC, Adamo ML, Clemmons DR, Rosen CJ. A circadian-regulated gene, Nocturnin, promotes adipogenesis by stimulating PPAR-gamma nuclear translocation. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10508-13. Epub 2010 May 24. PMCID:PMC2890788

Lecka-Czernik, B. Bone loss in diabetes: Use of anti-diabetic TZDs and secondary osteoporosis. Current Osteoporosis Reports. 2010; 8:178-184. PMID: 20809203 

Lecka-Czernik, B. Rosen CJ, Kawai, M. Skeletal Aging and the Adipocyte Program: New Insights from an ‘Old’ molecule. Cell Cycle. 2010 Sep 15;9(18):3648-54. Epub 2010 Sep 15. PMCID:PMC3047793

Lecka-Czernik, B. Aleglitazar, a dual PPAR alpha and gamma agonist for the potential oral treatment of type 2 diabetes. Investigational Drugs. 2010;13:793-801. PMID: 21046527

Krings, A., Rahman, S., Huang, S., Lu, Y., Czernik, P.J., Lecka-Czernik, B. Bone marrow fat has brown adipose tissue characteristics, which are attenuated with aging and diabetes. Bone. 2012 Feb;50(2):546-52. Epub 2011 Jun 24. PMCID:PMC3214232

Lecka-Czernik, B. Marrow fat metabolism is linked to the systemic energy metabolism. Bone. 2012 Feb;50(2):534-9. Epub 2011 Jul 4. PMCID:PMC3197966


Marcia F. McInerney, PhD Since joining CeDER in 2006

Angevine KR, Wuescher LM, Andrews K, Alexander LA, McInerney MF, Kieffer TJ,Mensah-Osman EJ. Menin and GIP are inversely regulated by food intake and diet via PI3/AKT signaling in the proximal duodenum. Nutr Diabetes. 2012 Dec 3;2:e55. PMCID: PMC3542434

Rasche SS, Phillips M, McInerney MF, Sercarz, EE and Quinn A. IL-13Ra1 Expression on Beta Cell-specific T cells in NOD Mice. Diabetes 2011; June 60 (6): 1716-25

Dudley RW, Slotterbeck BD, McInerney MF, Peseckis SM. Fatty acylation enhances cellular localization of dansylated phenylalanines. Mol Cell Biochem. Molecular and Cellular Biochemistry: Volume 346, Issue 1 (2011), Page 81.2010 Oct 8. PMID: 20931354

Ghosh S*, Kaw M*, Patel PR, Ledford KJ, Bowman TA, McInerney MF, Bourey RE, Erickson, SK and Najjar SM. Null mutation of Ceacam1 causes Non-alcoholic Steatohepatitis. Hepatic Medicine: Research and Evidence. Hepatic Medicine: Research and Evidence. 2010; 2:69–78. PMID: 21949477

Huang S, Kaw M, Harris MT, Ebraheim N, McInerney MF. Najjar SM, Lecka-Czernik B. Decreased osteoclastogenesis and high bone mass in mice with impaired insulin clearance due to liver-specific inactivation of CEACAM1. Bone. 2010 Apr;46(4):1138-45. Epub 2010 Jan 4. PMCID:PMC2862391

Michael P, Morran, M. Alexander, LA, Slotterbeck, B. McInerney MF. Dysfunctional Innate Immune Responsiveness to P. gingivalis in Diabetes. Oral Microbiology and Immunology. 2009 Aug;24(4):331-9. PMID: 19572897

Lee SJ, Heinrich G, Fedorova L, Al-Share QY, Ledford KJ, Fernstrom MA, McInerney MF, Erickson SK, Gatto-Weis C, Najjar SM. Development of nonalcoholic steatohepatitis in insulin-resistant liver-specific S503A carcinoembryonic antigen-related cell adhesion molecule 1 mutant mice. Gastroenterology. 2008 Dec;135(6):2084-95. Epub 2008 Aug 20. PMCID:PMC2784638

Morran, M, McInerney MF, M. Pietropaolo. Innate and Adaptive Autoimmunity in Type 1 Diabetes. Pediatr Diabetes. 2008 Apr;9(2):152-61. Epub 2008 Jan 25. PMID: 18221432

Quinn, A., McInerney, M.F. Huffman, D., McInerney, B.E., Mayo, S., Haskins, K., and Sercarz, E. T Cells to a Dominant Epitope of GAD65 Express a Public CDR3 Motif. Internat. Immunol. 2006 Jun;18(6):967-79. Epub 2006 Apr 26. PMID: 16641112

Mohammad, M., Morran, M. Slotterbeck, B., Leaman, D.W., Sun, Y. vonGrafenstein, H., Hong, S.C., and McInerney, MF. Dysregulated Toll-like Receptor Expression and Signaling in Bone Marrow-Derived Macrophages at the onset of Diabetes in the Nonobese Diabetic Mouse. Internat. Immunol. 2006 Jul;18(7):1101-13. Epub 2006 May 25. PMID: 16728431

Marcia F. McInerney, Lindsey A. Alexander, Michael P. Morran, Massimo Pietropaolo. Innate Immunity, Toll-like Receptors, and Diabetes. Current Immunology Reviews 2009; 5(2): 111-121. (In Press)


Nikolai Modyanov, PhD Since founding CeDER in 2006

Pestov NB, Korneenko TV, Shakhparonov MI, Shull GE, Modyanov NN. Loss of acidification of anterior prostate fluids in Atp12a-null mutant mice indicates that nongastric H-K-ATPase functions as proton pump in vivo. Am J Physiol Cell Physiol. 2006 Aug;291(2):C366-74. Epub 2006 Mar 8. PubMed PMID: 16525125.

Radkov R, Kharoubi-Hess S, Schaer D, Modyanov NN, Geering K, Horisberger JD. Role of homologous ASP334 and GLU319 in human non-gastric H,K- and Na,K-ATPases in cardiac glycoside binding. Biochem Biophys Res Commun. 2007;356(1):142-6. PMID: 17349614

Dmitriev RI, Korneenko TV, Bessonov AA, Shakhparonov MI, Modyanov NN, Pestov NB. Characterization of hampin/MSL1 as a node in the nuclear interactome. Biochem Biophys Res Commun. 2007 Apr 20;355(4):1051-7. Epub 2007 Feb 23. PubMed PMID:17335777; PubMed Central PMCID: PMC1855298

Pestov, N.B., Ahmad, N., Korneenko, T.V., Zhao, H., Radkov, R., Schaer,D., RoyS, BibertS, Geering, K. and Modyanov, N.N. (2007). Evolution of Na,K-ATPase bm-subunit into a co-regulator of transcription in placental mammals. Proc. Natl. Acad. Sci. USA 104:11215-11220.

Pestov, N.B., Zhao, H., Basrur, V., Modyanov N.N. (2011) Isolation and characterization of BetaM protein encoded by ATP1B4--a unique member of the Na,K-ATPase ß-subunit gene family.  Biochem. Biophys. Res. Commun. 412(4):543-548. 

Pestov NB, Dmitriev RI, Kostina MB, Korneenko TV, Shakhparonov MI, Modyanov NN. (2012)  Structural evolution and tissue-specific expression of tetrapod-specific second isoform of secretory pathway Ca(2+)-ATPase.  Biochem Biophys Res Commun. 2012 Jan 27;417(4):1298-1303.

Pestov NB, Korneenko TV, Shakhparonov MI, Modyanov NN.Postnatal regulation of X,K-ATPases in rat skin and conserved lateroapical polarization of Na,K-ATPase in vertebrate epidermis. Exp Dermatol. 2013:22(6):423-5. PMID 23651441

Salhi A, Lamouroux C, Pestov NB, Modyanov NN, Doucet A, Crambert G. A link between fertility and K(+) homeostasis: role of the renal H,K-ATPase type 2. Pflugers Arch. 2013 Feb 26. [Epub ahead of print] PMID: 23440459

Sonia M. Najjar, PhD Since founding CeDER in 2006

Park, S.-Y., Choo, Y.-R., Kim, H.-J., Hong, E-G., Higashimori, T., Lee, S.J. Goldberg, I.J., Shulman, G.I., Najjar, S.M., and Kim, J.K. Mechanism of glucose intolerance with dominant-negative mutation of CEACAM1. Am. J. Physiol. Endocrinol Metab. 2006;291(3): E517-E524. PMID: 16638824

Nagaishi, T., Pao, L., Lin, S.-H., Iijima, H., Kaser, A., Qiao, S.-W., Chen, D., Glickman, J., Najjar, S.M., Nakajima, A., Neel, B.G., and Blumberg, R.S. SHP1 Dependent T cell inhibition by CEACAM1 Isoforms Expressing a Long Cytoplasmic Domain. Immunity. 2006; 25(5): 769-781. PMID: 17081782

Wisløff, U., Støylen, A., Loennechen, J.P., Bruvold,M., 
Rognmo, Ø., Haram, P.H., Tjønna, A.E., Helgerud, J., Slørdahl, S.A., Lee, S.J., Videm, V., Bye, A., Smith, G.L., Najjar, S.M., Ellingsen, Ø., and Skjærpe, T. Superior cardiovascular
 effect of aerobic interval-training versus moderate continuous training 
in elderly heart failure patients: A randomized controlled study.
 Circulation. 2007;115(24): 3086-3094. PMID: 175487226

Bye, A., Langaas, M., Høydal, M.A., Kemi, O.J., Heinrich, G., Koch, L.G., Britton, S.L., Najjar, S.M., Ellingsen, O., and Wisloff, U. Aerobic capacity-dependent differences in cardiac gene expression. Physiol. Genomics. 2008;33: 100-109. PMID: 18171719. PMID: 18171719

Bye A, Sørhaug S, Ceci M, Høydal MA, Stølen T, Heinrich G, Tjønna AE, Najjar SM, Nilsen OG, Catalucci D, Grimaldi S, Contu R, Steinshamn S, Condorelli G, Smith GL, Ellingsen O, Waldum H, Wisløff U. Carbon monoxide levels experienced by heavy smokers impair aerobic capacity and cardiac contractility and induce pathological hypertrophy.  Inhal Toxicol. 2008 May;20(7):635-646. PMID: 18464052

Schjerve, I.E., Tyldum, G.A., Tjønna, A.E., Stølen, T.O., Loennechen, J.P., Hansen, H.E., Haram, P.M., Heinrich, G., Bye, A., Najjar, S.M., Smith, G.L., Slørdahl, S.A., Kemi, O.J., Wisløff, U. Both aerobic endurance and strength training programs improve cardiovascular health in obese adults. Clin. Sci (Lond). 2008;115: 283-293. PMID: 18338980.

Arnt Erik TjØnna, MSc; Sang Jun Lee, PhD;  Øivind Rognmo, MSc; Tomas O. StØlen, MSc; Anja Bye, MSc; Per Magnus Haram, PhD; Jan Pål Loennechen, PhD; Qusai Y. Al-Share, MSc; Eirik Skogvoll, PhD; Stig a SlØrdahl, PhD; Ole J. Kemi, PhD; Sonia M. Najjar, PhD; Ulrik WislØff, PhD. Aerobic Interval Training Versus Continuous Moderate Exercise as a Treatment for the Metabolic Syndrome A Pilot Study. Circulation. 2008;118:346-354. PMCID: PMC2777731

DeAngelis AM, Heinrich G, Dai T, Bowman TA, Patel PR, Jun Lee S, Hong EG, Young Jung D, Assmann A, Kulkarni RN, Kim JK, Najjar, SM, CEACAM1: A Link Between Insulin and Lipid Metabolism. Diabetes. 2008 Sept;57(9):2296-303. PMCID: PMC2518480 

Sang Jun Lee, Garrett Heinrich, Larisa Federova, Qusai Y. Al-Share, Kelly J. Ledford, Mats A. Fernstrom, Marcia F. McInerney, Sandra K. Erickson, Cara Gatto-Weis, Sonia M. Najjar. Development of Non-alcoholic Steatohepatitis in Insulin Resistant L-SACC1 Mice.  Gastroenterology. 2008; 135: 2084-2095. *Shared first authorship. PMCID: PMC2784638

Haram, P.M., Kemi, O.J., Lee, S.J., Bendheim, M.Ø., Al-Share, Q.Y., Waldum, H.L., Gilliam, L.J., Koch, L.G., Britton, S.L., Najjar, S. M. Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity. Cardiovascular Res. 2009 Mar 1;81(4):723-32. *Shared senior authorship. PMCID: PMC2642601

Gayen, J.R., Saberi, M., Schenk, S., Biswas, N., Vaingankar, S.M., Cheung, W.W., Najjar, S.M., O'Connor, D.T., Bandyopadhyay, G., and Mahata, S.K. A Novel Pathway of Insulin Sensitivity in Chromogranin A Null Mice: A Crucial Role for Pancreastatin in Glucose Homeostasis. J. Biol. Chem. 2009 Oct 16;284(42):28498-509. PMCID: PMC2781393 

Huang S, Kaw M, Harris MT, Ebraheim N, McInerney MF, Najjar SM, Lecka-Czernik B. (2010) Decreased osteo-clastogenesis and high bone mass in mice with impaired insulin clearance due to liver-specific inactivation to CEACAM1. Bone. 2010 Apr;46(4):1138-45. PMCID: PMC2862391

Warrier M, Hinds TD, Jr, Ledford KJ, Cash HA, Patel PR, Bowman TA, Stechschulte LA, Young W, Shou W, Najjar SM* and Sanchez ER*. Susceptibility to Diet-induced Hepatic Steatosis and Glucocorticoid Resistance In FK506-Binding Protein 52-Deficient Mice. Endocrinology. 2010;151:3225-36. *shared senior authorship. PMCID: PMC2903936

Heinrich G, Ghosh S, DeAngelis MA, Schroeder-Gloeckler JM, Patel PR, Castaneda TR, Jeffers S, Lee AD, Jung DY, Zhang Z, Opland DM, Myers MG, Jr, Kim JK and Najjar SM. A Role for CEACAM2 in the Central Control of Energy Balance and Peripheral Insulin Action. Gastroenterology. 2010;139: 644-652. PMCID: PMC2910848

Ghosh S*, Kaw M*, Patel PR, Ledford KJ, Bowman TA, McInerney MF, Bourey RE, Erickson, SK and Najjar SM. Null mutation of Ceacam1 causes Non-alcoholic Steatohepatitis. Hepatic Medicine: Research and Evidence. Hepatic Medicine: Research and Evidence. 2010;2: 69–78. PMID: 21949477; PMCID: PMC3177946

Hinds TD Jr, Ramakrishnan SK, Cash HA, Stechschulte LA, Heinrich G, Najjar SM and Sanchez ER. Discovery of Glucocorticoid Receptor-β in Mice with a Role in Metabolism. Molecular Endocrinology. 2010;24(9):1715-1727. PMCID: PMC2940475

Bowman TA*, Ramakrishnan SK*; Kaw M, Lee SJ, Patel PR, Golla VK, Bourey RE, Haram PM, Kock LG, Britton SL, Wisloff U, Lee AD, and Najjar SM. Caloric restriction reverses hepatic insulin resistance and steatosis in rats with low aerobic capacity. Endocrinology. 2010;151: 5157-5164. PMCID: PMC2954714.

Najjar SM. (2010) Nonalcoholic fatty liver disease. In: “Metabolic Basis of Obesity”. (Rexford S. Ahima, Ed) World Scientific Publishing Co., published by Spriger-Verlag.

Wuescher LM, Angevine KR, Hinds T, Ramakrishnan SK, Najjar SM and Mensah-Osman EJ. Insulin regulates Menin expression, cytoplasmic localization and interaction with FOXO 1. Am. J. Physiol. Endocrinol. Metab. 2011;301(3): E474-83. PMID: 21693693 

Tiano JP, Delghingaro-Augusto V, Le May C, Liu, S., KawMK, Khuder, S.S., Latour MG, Bhatt SA, Korach KS, Najjar SM, Prentki M, Mauvais-Jarvis F. Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetes. J. Clinical Investigation. 2011;121(8): 3331-42. PMCID: PMC3148728 

Hinds TD Jr, Stechschulte LA, Cash HA, Whisler D, Banerjee A, Yong W, Khuder SS, Kaw MK, Shou W, Najjar SM, Sanchez ER.Protein Phosphatase 5 mediates lipid metabolism through reciprocal control of glucocorticoid and PPARγ receptors. J. Biol. Chem. 2011;286(50):42911-22. PMID: 21994940 

P. R. Patel; S. K. Ramakrishnan; M. K. Kaw; C. K. Raphael; S. Ghosh; J. S. Marino; G. Heinrich; S. J. Lee; R. E. Bourey; J. W. Hill; D. Y. Jung; D. A. Morgan; J. K. Kim; S. K. Rahmouni; S. M. Najjar. Increased metabolic rate and insulin sensitivity in male mice lacking the carcino-embryonic antigen-related cell adhesion molecule 2, Diabetologia. 2011;55(3):861. PMID: 22159884

Gupta S, Yan Y, Malhotra D, Liu J, Xie Z, Najjar SM, and Shapiro JI. Ouabain and insulin induce sodium pump endocytosis in renal epithelium. (2012) Hypertension 59(3): 665-72. PMID: 22311908.

Chen X-Y, Gu X-T, ‎Saiyin H, Wan B, ‎Zhang Y-J, Li J, Wang Y-L, Gao R, Wang Y-F, Dong W-P, Najjar SM, Zhang C-Y, Ding H-F, Liu JO and Yu L. Brain selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic b-cells. (2012) J. Biol. Chem. PMID: 22798068.

Friedman TC, Sinha-HikimI, ParveenM, Najjar SM, Liu Y, Mangubat M, ShinC-S, LyzlovA, Ivey R, Shaheen M, FrenchSW, Sinha-Hiki, AP. Additive effects of nicotine and high-fat diet on hepatic steatosis in male mice. (2012) Endocrinology. 153(12): 5809-20. PMID: 23093702.

Huang J, Ledford KJ, Pitkin WB, Russo L, Najjar SM* and Siragy HM*. Targeted deletion of murine carcinoembryonic antigen-related cell adhesion molecule 1 activates PI3K-Akt signaling and contributes to the expression of (Pro) renin receptor via transcription factors CREB family and NF-κB transcription factors. (2013) Hypertension 62(2): 317-323. (*Shared Senior Authorship). PMID: 23734002.

Najjar SM, Ledford KJ, Abdallah SL, Paus A, Russo L, Kaw MK, Ramakrishnan SK, Muturi HT, Raphael CK, Lester SG, Heinrich G, Pierre SV, Benndorf R, Kleff V, Jaffa AA, Levy E, Vazquez G, Goldberg IJ, Beauchemin N, Scalia R, Ergün S. Ceacam1 deletion causes vascular alterations in large vessels. (2013) Am J Physiol Endocrinol Metab. 305(4): E519-29. PMID: 23800882.

Bourey RE, Kaw MK, Lesler SG, Ghanem SS, and Najjar SM. (2013) Diabetes. In: “Diet, Exercise, and Chronic Disease: The Biological Basis of Prevention”. (C. Murray Ardies, Ed). CRC Press; pp76-96.

Ebke LA, SlotterbeckBD, Nestor-KalinoskiAL, Al DieriAG, Lester SG, Russo L, NajjarSM, von GrafensteinH, and McInerney MF. Tight Association between Macrophages and Adipocytes in Obesity: Implications for Adipocyte Preparation (2013) Obesity, in press


Joshua J. Park, PhD

Park,J.J., Cawley N.W., and Loh, Y.P. (2008). Carboxypeptidase E cytoplasmic tail anchors hormone vesicles to microtubule motors for transport and activity – dependent secretion. Molecular Endocrinology, 22(4): 989-1005.

Park,J.J., Cawley N.W., and Loh, Y.P. (2008). Carboxypeptidase E cytoplasmic tail anchors BDNF vesicles to microtubule motors for transport and activity-dependent secretion. Molecular and Cellular Neuroscience, 39(1): 63-73.

Park,J.J. and Loh, Y.P. (2008). How Peptide Hormone Vesicles are Transported to the Secretion Site for Exocytosis. Molecular Endocrinology, 22(12): 2583-95.

Park, J.J., Koshimizu, H., and Loh, Y.P. (2009). Biogenesis and Transport of Secretory Granules to Release Site In Neuroendocrine cells. Journal of Molecular Neuroscience, 37(2): 151-9.

Lou, H., Park, J.J., Sarcon, A., Adams, T., Cawley, N.X., and Loh, Y.P. (2010). Carboxypeptidase E Cytoplasmic Tail Mediates Localization of Synaptic Vesicles to the Pre-Active Zone in Hypothalamic Nerve Terminals. (as a co-author) Journal of Neurochemistry, 114(3): 886-96.

Hensley, K., Venkova, K., Christov, A., Gunning, W., and Park, J.J. (2011). Collapsin response mediator protein-2: An emerging pathologic feature and therapeutic target for neurodisease indications. Molecular Neurobiology, 43(3): 180-91.

Park, J.J., Gondre-Lewis, M., Kim, T., and Loh, Y.P. (2011). A distinct trans Golgi network subcompartment for sorting of synaptic and granule proteins in neuroendocrine cells. Journal of Cell Science, 124 (5): 735-44.

Park,J.J. and Loh, Y.P. (2011). Visualization of Peptide Secretory Vesicles in Living Nerve Cells. Methods in Molecular Biology, 789:137-45.

Cawley, N.X., Wetsel, W.C., Murthy, S.R.K., Park, J.J., Pacak, K., and Loh, Y.P. (2012). New Roles of Carboxypeptidase E in Endocrine and Neural Function and Cancer. Endocrine Reviews 33:216-253

Park, J.J., Rubio, M.V., Zhang, Z., Um, T., Xie, Y., Knoepp, S.M., Snider, A.J., Gibbs, T.C., and Meier, K.E. (2012). Effects of lysophosphatidic acid on calpain-mediated proteolysis of focal adhesion kinase in human prostate cancer cells. Prostate, 72:1595-610

Lou, H., Park, J.J., Phillips, A., and Loh, Y.P. (2012) Gamma-Adducin Promotes Process Outgrowth and Secretory Protein Exit from the Golgi Apparatus. (as co-first author) Journal of Molecular Neuroscience, 49:1-10

Gondre-Lewis, M., Park, J.J., and Loh, Y.P. (2012) Cellular Mechanisms for the Biogenesis and Transport of Synaptic and Dense-Core Vesicles. (as co-first author) International Review of Cell and Molecular Biology, 299:27-115

Makani, V., Hall, J, Qamar, K., Jain, P., Hensley, K., and Park, J.J. (2013) Tianeptine interferes with microtubule organization and hormone secretion in pheochromocytoma cells. Molecular and Cellular Endocrinology, 381: 175-187

Makani, V., Sultana R., Dowling, A., Tatangelo, M., P., Butterfield, A., Hill, J., and Park, J.J. Annexin A1 complex mediates oxytocin vesicle transport. Accepted to ‘Journal of Neuroendocrinology'.


Edwin R. Sanchez, PhD  Since founding CeDER in 2006

Yang, Z., Wolf, I. M., Chen, H., Periyasamy, S., Chen, Z., Yong, W., Shi, S., Zhao, W., Xu, J., Srivastava, A., Sanchez, E. R. & Shou, W. FK506-binding protein 52 is essential to uterine reproductive physiology controlled by the progesterone receptor a isoform. Mol Endocrinol. 2006;20:2682-2694. PMC2661205

Heitzer, M. D., Wolf, I. M., Sanchez, E. R., Witchel, S. F. & Defranco, D. B. Glucocorticoid receptor physiology. Rev Endocr Metab Disord. 2007; 8:321-330. PMID: 18049904

Yong, W., Yang, Z., Periyasamy, S., Chen, H., Yucel, S., Li, W., Lin, L. Y., Wolf, I. M., Cohn, M. J., Baskin, L. S., Sanchez, E. R. & Shou, W. Essential role for Co-chaperone Fkbp52 but not Fkbp51 in androgen receptor-mediated signaling and physiology. J Biol Chem. 2007;282:5026-5036. PMC2577319

Yong, W., Bao, S., Chen, H., Li, D., Sanchez, E. R. & Shou, W. Mice lacking protein phosphatase 5 are defective in ataxia telangiectasia mutated (ATM)-mediated cell cycle arrest. J Biol Chem. 2007;282:14690-14694. PMC2577320

Periyasamy, S., Warrier, M., Tillekeratne, M. P., Shou, W. & Sanchez, E. R. The immunophilin ligands cyclosporin a and FK506 suppress prostate cancer cell growth by androgen receptor-dependent and -independent mechanisms. Endocrinology. 2007;148:4716-4726. PMC2639775

Hinds, T. D., Jr. & Sanchez, E. R. Protein phosphatase 5. Int J Biochem Cell Biol. 2008; 40(11): 2358-2362. PMC2551559

Banerjee, A., Periyasamy, S., Wolf, I. M., Hinds, T. D. J., Yong, W., Shou, W. & Sanchez, E. R. Control of glucocorticoid and progesterone receptor subcellular localization by the ligand-binding domain is mediated by distinct interactions with tetratricopeptide repeat proteins. Biochemistry. 2008; 47:10471-10480. PMCID:PMC3045568

Wolf, I. M., Periyasamy, S., Hinds, T. D., Jr., Yong, W., Shou, W. & Sanchez, E. R. Targeted ablation reveals a novel role of FKBP52 in gene-specific regulation of glucocorticoid receptor transcriptional activity. J Steroid Biochem Mol Biol. 2009; 113:36-45. PMC2675912

Warrier, M., Hinds, T. D. J., Ledford, K. J., Cash, H. A., Patel, P. R., Bowman, T. A., Stechschulte, L. A., Yong, W., Shou, W., Najjar, S. M.* & Sanchez, E. R *. Susceptibility to diet-induced hepatic steatosis and glucocorticoid resistance in FK506-binding protein 52-deficient mice. Endocrinology. 2010; 151: 3225-3236. PMC2903936. * Equal contribution

Periyasamy, S., Hinds, T. J., Shemshedini, L., Shou, W. & Sanchez, E. R. FKBP51 and Cyp40 are positive regulators of androgen-dependent prostate cancer cell growth and the targets of FK506 and cyclosporin A. Oncogene. 2010; 29:1691-1701. PMCID:PMC3040472

Hinds, T. D. J., Ramakrishnan, S., Cash, H. A., Stechschulte, L. A., Heinrich, G., Najjar, S. M. & Sanchez, E. R. Discovery of glucocorticoid receptor-beta in mice with a role in metabolism. Mol Endocrinol. 2010; 24:1715-1727. PMC2940475

Chen, H., Yong, W., Hinds, T. D. J., Yang, Z., Zhou, Y., Sanchez, E. R. & Shou, W. Fkbp52 regulates androgen receptor transactivation activity and male urethra morphogenesis. J Biol Chem. 2010; 285: 27776-27784. PMC2934645

Terry D. Hinds, Jr., Lance A. Stechschulte, Harrison Cash, Donald Whisler,Ananya Banerjee, Weidong Yong,Khuder SS, Kaw MK, Weinian Shou, Najjar SM, and Edwin R. Sánchez. Protein Phosphatase 5 Mediates Lipid Metabolism Through Reciprocal Control of Glucocorticoid Receptor and Peroxisome Proliferator-Activated Receptor (PPAR-g). Journal of Biological Chemistry, 2011 Dec 16;286(50):42911-22. Epub 2011 Oct 12.

Lance A. Stechschulte, Edwin R. Sánchez. (2011) FKBP51-a selective modulator of glucocorticoid and androgen sensitivity. Current Opinion in Pharmacology. 2011 May 10. [Epub ahead of print]

Marino, J. S., Hinds, T. D. J., Hoover, R. A., Ondrus, E., Onion, J. L., Dowling, A. R., McLoughlin, T. J., Sanchez, E. R. & Hill, J. W. Suppression of Protein Kinase C Theta Contributes to Enhanced Myogenesis in vitro via IRS1 and ERK1/2 phosphorylation. BMC Cell Biol In press, (2013). 


Cynthia M. Smas, PhD Since joining CeDER in 2006

Ren G, Beech C, Smas CM. The immunoglobulin superfamily protein differentiation of embryonic stem cells 1 (dies1) has a regulatory role in preadipocyte to adipocyte conversion., PLoS One. 2013 Jun 17;8(6):e65531. doi: 10.1371/journal.pone.0065531. Print 2013. PMID23799023

Yang X, Heckmann BL, Zhang X, Smas CM, Liu J., Distinct mechanisms regulate ATGL-mediated adipocyte lipolysis by lipid droplet coat proteins., Mol Endocrinol. 2013 Jan;27(1):116-26. doi: 10.1210/me.2012-1178. Epub 2012 Nov 30. PMID: 23204327

Ren G, Kim JY, Smas CM., Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism., Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E334-51. doi: 10.1152/ajpendo.00084.2012. Epub 2012 May 8. PMID: 22569073

Wu Y, Zhou S, Smas CM. Downregulated expression of the secreted glycoprotein follistatin-like 1 (Fstl1) is a robust hallmark of preadipocyte to adipocyte conversion. Mech Dev. 2010 Apr;127(3-4):183-202. Epub 2010 Jan 4. PMCID:PMC2849861 

Wang, Y, Zhao, L., Smas, C.M. and Sul, H.S. Pref-1 interacts with fibronectin to inhibit adipocyte differentiation. Mol. Cell. Biol. 2010;30:3480-3492. PMCID:PMC2897553

Lee, J.H., Zhou, S. and Smas, C.M. Identification of RANBP16 and RANBP17 as Novel Interaction Partners for the bHLH Transcription Factor E12. J. Cell. Biochem.2010;11:195-206. PMCID:PMC2930062

Charkrabarti, P., English, T., Shi, J., Smas, C.M. and Kandror, K. The mTOR complex 1 suppresses lipolysis, stimulated lipogenesis and promotes fat storage.  Diabetes. 2010;59:775-781.  PMCID:PMC2844824

Liu K, Zhou S, Kim JY, Tillison K, Majors D, Rearick D, Lee JH, Fernandez-Boyanapalli RF, Barricklow K, Houston MS, Smas CM. Functional analysis of FSP27 protein regions for lipid droplet localization, caspase-dependent apoptosis, and dimerization with CIDEA. Am J Physiol Endocrinol Metab. 2009 Dec;297(6):E1395-413. Epub 2009 Oct 20. PMID: 19843876

Wu Y, Smas CM. Wdnm1-like, a new adipokine with a role in MMP-2 activation. Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E205-15. Epub 2008 May 20. PMCID:PMC2493586 

Kim, J.Y., Lui, K., Zhou, S., Tillison, K., Wu, Y., and Smas, C.M. Assessment of fat specific protein 27 (FSP27) in the adipocyte lineage suggests a dual role for FSP27 in adipocyte metabolism and cell death. Am. J. Physiol. Endocrinol. Metab. 2008;294:E654-E667. PMID: 18198355

Wu, Y., Kim, J.Y., Zhou, S. and Smas, C.M. Differential screening identifies transcripts with depot-dependent expression in white adipose tissues. BMC Genomics. 2008;9:397. PMCID:PMC2547859

Wu Y, Smas CM. Expression and regulation of transcript for the novel transmembrane protein Tmem182 in the adipocyte and muscle lineage. BMC Res Notes. 2008 Sep 19;1:85. PMCID:PMC2564950 

Kim, J.Y., Tillison, K.S., Zhou. S. Wu, Y. and Smas, C.M. The Major Facilitator Superfamily Member Slc37a2 is a Novel Macrophage-Specific Gene Selectively Expressed in obese White Adipose Tissue. Am. J .Physiol. Endocrinol. Metab. 2007;293: E110—E120. PMID: 17356011

Kim, J.Y., Wu, Y., and Smas, C.M. Characterization of ScAP-23, a new cell line from murine subcutaneous adipose tissue, identifies genes for the molecular definition of preadipocytes.  Physiol. Genomics. 2007;31:328-342. PMID: 17609412

Kim, J.Y., Tillison, K.S., Zhou, S. Lee, J.H., and Smas, C.M. Differentiation-dependent expression of Adhfe1 in adipogenesis. Arch. Biochem. Biophys. 2007; 464:100-111. PMCID:PMC2426734

Kim, J.Y., Tillison, K., Lee, J.H., Rearick, D.A., and Smas, C.M. The Adipose Tissue Triglyceride Lipase ATGL/PNPLA2 is Downregulated by Insulin and TNFa in 3T3-L1 Adipocytes and is a Target for Transactivation by PPARg. American J. Phys. Endo. Metabol. 2006;291:E115-E127. PMID: 16705060


Stanislaw M. Stepkowski, PhD

Ross JA, Nagy ZS, Cheng H, Stepkowski SM, Kirken RA. Regulation of T cell homeostasis by Jaks and Stats. Arch Immunol Ther Exp. 2007;55:231-45. PMID:17659375

Chen W, Diao J, Stepkowski SM, Zhang L. Both Infiltrating Regulatory T Cells and Insufficient Antigen Presentation Are Involved in Long-Term Cardiac Xenograft Survival. Journal of Immunology. 2007;179:1542-8. PMID: 17641020

Stepkowski SM, Chen W, Ross J, Nage Z, Kirken R. Stat3: The important regulator of multiple cell functions. Transplantation. 2008;85:1372. PMID:18497672

Wenderfer, SE, Stepkowski, SM, Braun, MC. Prolonged Survival and Reduced Renal Injury in the MRL/lpr Mouse after Treatment with a Second Generation Sphingosine-1-Phosphate Receptor Agonist. Kidney International. 2008;74:13190

Khattar M, Chen W, Stepkowski SM. Expanding and converting regulatory T cells. Arch. Immunol. Ther. Exp. 2009;57:199. PMID: 19479206

Fernandes I, Zhang Y, Qi Y, Wang ME, Podder H, Lisik W, Knight R, Kahan BD, Stepkowski SM. Impact of reduced nephron mass on cyclosporine- and/or sirolimus-induced nephrotoxicity. Transplantation. 2009; 88:1323. PMID:20029328

Wang G, Guo Z, Miyahara Y, Khattar M, Linkes SP, Sun Z, He X, Stepkowski SM, Chen W. IL-2-deprivation and TGF-b are two non-redundant suppressor mechanisms of CD4⁺CD25⁺Foxp3⁺ regulatory T cells which jointly restrain CD4⁺CD25^– cell activation. Immunology Letters. 2010 Aug 16;132(1-2):61-8. PMCID:PMC2922908

Guo G, Wang G, Miyahara Y, Khattar M, Links S, Chen W, He X, Stepkowski SM. IL-7, but not thymic stromal lymphopoietin (TSLP), contributes to the programmatic generation of memory CD4⁺ T cells. Immunology Letters. 2010;128:116. PMID: 20064560

Wang G, Guo Z, Miyahara Y, Khattar M, Linkes SP, Sun Z, He X, Stepkowski SM, Chen W. Default generation of neonatal regulatory T cells. J Immunol. 2010;185:71. PMID: 20498359

Wang G, Khattar M, Guo Z, Miyahara Y, Linkes SP, Sun Z, Stepkowski SM, Chen W. IL-2-deprivation and TGF-b are two non-redandant suppressor mechanisms of CD+CD25+ regulatory T cells which jointly restrain CD4+CD25- cell activation. Immunol Lett. 2010;132:61. PMCID:PMC2922908

Li J, Chen G, Ye P, Wang S, Zhang K, Chen W^‡, Stepkowski SM, Junhua Li J, Zhong S, Xia J. CCR5 Blockade in Combination with Cyclosporine Increased Cardiac Graft Survival and Generated Alternatively Activated Macrophages in Primates. J. Immunol. 186:3753-61, 2011.

Miyahara Y, Khattar M, Schroder P, Mierzejewska B, Deng R, Han R, Hancock WW, Chen W, Stepkowski SM. An anti-TCRb monoclonal antibody induces long-term allograft survival by reducing antigen-reactive T cells and sparing regulatory T cells. American J Transplantation 12:1409-18, 2012

Mierzejewska B, Baum C, Schroder PA, Durlik M, Lisik W, Rees M, Stepkowski SM. Diversity in kidney paired donation programs accommodates local requirements. Annals of Transplantation 2013 in press

Khattar M, Deng R, Kahan BD, Schroder PM, Phan T, Rutzky LP, Stepkowski SM. Novel sphingosin-1-phosphate receptor modulator KRP203 combined with locally-delivered regulatory T cells induces permanent acceptance of pancreatic islet allografts. Transplantation 2013 in press

Guo Z,Khattar M, Schroder PM, Miyahara Y, Wang G,He X, Chen W, Stepkowski SM. A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells. Journal of Immunology 2013 in press


Guillermo Vazquez, PhD  Since joining CeDER in 2008

Smedlund K, Vazquez G. Involvement of Native TRPC3 Proteins in ATP-dependent expression of VCAM-1 and Monocyte Adherence in Coronary Artery Endothelial Cells. Arterioscler. Thromb. Vasc. Biol. 2008;28:2049-2055. PMID:18787184

Putney JW Jr., Smyth JT, Trebak M, Lemonnier L, Vazquez G, Bird G. Activation and Regulation of TRPC Cation Channels. Cell Membranes and Free Radicals Research, 1, 51-55. 2008.

Vazquez, G. TRPC Channels: Emerging Roles in Cardiovascular Physiology and Disease. Frontiers in Bioscience (Schol. Ed.), 15, 1022-1033. 2009.

Tano JY, Smedlund K, Vazquez G. Endothelial TRPC3/6/7 Proteins at the Edge of Cardiovascular Disease. Cardiovasc. Hematol. Agents Med. Chem. 2010;8:1-11. PMID: 20214601

Smedlund K, Tano JY, Vazquez G. The Constitutive Function of Native TRPC3 Channels Modulates VCAM-1 Expression in Coronary Endothelial Cells through NFkappaB Signaling. Circ Res. 2010;106:1479-1488. PMID: 20360250

Vazquez G., Tano JY., Smedlund K. On the potential role of source and species of diacylglycerol in phospholipase-dependent regulation of TRPC3 channels. Channels (Austin). 2010; 4:232-240. PMID:20458187

Tano JY, Vazquez G. Requirement for non-regulated, constitutive calcium influx in macrophage survival signaling. Biochem. Biophys. Res. Commun. 2011;407: 432-437. PMID:21414290

Vazquez G, Smedlund K, Tano JY, Lee R. Molecular and cellular aspects of atherosclerosis: emerging roles of TRPC channels. In: Coronary Artery Diseases, Ed: Angelo Squeri, MD InTech Publisher. 2011. ISBN 978-953-307-712-3.

Smedlund K, Tano JY, Margiotta J, Vazquez G. Evidence for operation of nicotinic and muscarinic acetylcholine receptor-dependent survival pathways in human coronary artery endothelial cells. Journal of Cell Biochemistry, 112, 1978-1984. 2011.

Vazquez G. TRPC Channels as Prospective Targets in Atherosclerosis: terra incognita. Frontiers in Bioscience, 2012 Jan 1;4:157-66. PMID:22202050

Tano JY, Smedlund K, Lee R, Abramowitz J, Birnbaumer L, Vazquez G. . Impairment of survival signaling and efferocytosis in TRPC3-deficient macrophages. Biochem. Biophys. Res. Commun. 2011 Jul 8;410(3):643-7. PMID:21684255

Vazquez G, Smedlund K, Tano JY, Lee R. Molecular and cellular aspects of atherosclerosis: emerging roles of TRPC channels. In: Coronary Artery Diseases, Ed: Angelo Squeri, MD InTech Publisher. ISBN 978-953-307-712-3. 2011

Tano JY, Lee RH, Vazquez G. Involvement of calmodulin and calmodulin kinase II in tumor necrosis factor alpha-induced survival of bone marrow derived macrophages. Biochemical and Biophysical Research Communications, 2012 Oct 12;427(1):178-84.PMID:22989752

Smedlund K, Bah M, Vazquez G. On the role of endothelial TRPC3 channels in endothelial dysfunction and cardiovascular disease. Cardiovasc. Hematol. Agents Med. Chem. 2012 Sep;10(3):265-74. PMID:22827251

Tano JY, Lee RH, Vazquez G. Macrophage function in atherosclerosis: potential roles of TRP channels. Channels (Austin), ”. Channels (Austin),  2012 May-Jun;6(3):141-8.PMID:22909953

Najjar SM, Ledford KJ, Abdallah SL, Paus A, Russo L, Kaw MK, Ramakrishnan SK, Muturi HT, Raphael CK, Lester SG, Heinrich G, Pierre SV, Benndorf R, Kleff V, Jaffa AA, Lévy E, Vazquez G, Goldberg IJ, Beauchemin N, Scalia R, Ergün S. Ceacam1 deletion causes vascular alterations in large vessels. Am J Physiol Endocrinol Metab. 2013 Aug;305(4):E519-29.PMID:23800882

Tano JY, Solanki S, Lee RH, Smedlund K, Birnbaumer L, Vazquez G. Bone Marrow Deficiency of TRPC3 Channel reduces early lesion burden and necrotic core of  advanced plaques in a mouse model of atherosclerosis, Cardiovascular Research 2013 (in press)