Center for Diabetes and Endocrine Research (CeDER)

Raymond Bourey, M.D., F.A.C.P., F.A.C.P., F.A.A.S.M.

Raymond E. Bourey, MD. Interim Division Chief of Endocrinology, Diabetes and Metabolism and Medical Director of the Regional Center for Sleep Medicine.

Dr. Bourey received his M.D. degree in 1982 and completed his residency training in Internal Medicine in Southern Illinois University School of Medicine. He then carried out a fellowship with in Applied Physiology
and in Metabolism in Washington University School of Medicine, where he subsequently served as Assistant Professor of Medicine until he moved to Toledo in 1994.

Recognized for early contributions to understanding of exercise, muscle glucose metabolism and aging, Dr. Bourey currently focuses on research of neuroendocrine control of appetite, sleep, and metabolism.

Dr. Bourey identified a connection between poor sleep and high morning blood sugars in diabetics. He subsequently undertook additional training and study in sleep medicine, which he felt, as an endocrinologist and exercise physiologist, represented a "back door” to study metabolic control by brain and central nervous system.

Dr. Bourey’s clinical research currently centers on deleterious effects of menopause on sleep and metabolism. Menopause can be surgical, medication induced (chemotherapy), or a natural consequence of aging.

Menopause is associated with disruption of sleep and features of the metabolic syndrome including obesity, hypertension, hyperlipidemia, and insulin resistance. A large body of evidence supports a direct metabolic relationship between sleep disruption and development of the metabolic syndrome. Clinical studies are in progress to assess the (1) relationship between sleep disruption as measured by EEG spectral analysis or
cyclic alternating pattern of arousal (CAP) and nocturnal hyperglycemia as measured by continuous interstitial fluid glucose monitoring, (2) relationship of sleep disruption to hot flashes or vasomotor events measured by skin conductance, and (3) treatment of menopausal sleep disruption by modulators of voltage-gated calcium channels.

Dr. Bourey’s laboratory research focuses on two related areas. Mice with fragmented sleep develop abdominal obesity, insulin resistance and other features of the metabolic syndrome. Work is in progress to evaluate related changes in intermediary liver metabolism. Rodents with insufficient estrogen action through estrogen receptor α (ERα) also develop obesity, insulin resistance, and abnormal insulin secretory response. ERα is found in brain areas related to sleep, appetite, and locomotion, as well as organs of insulin action including pancreas, liver, fat, and muscle. In collaboration with other members of CeDER, progress is being made toward elucidation of non-genomic and genomic mechanisms for increased appetite, decreased metabolic rate, insulin resistance, abnormal insulin secretion, and obesity caused by estrogen withdrawal or insufficiency.

Dr. Bourey had published more than 22 peer-reviewed articles and more than 50 clinical articles and reports. He has only returned to academic medicine recently, but his research direction is fundamental to the growth of translational research in this institution.

Last Updated: 6/9/16