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A University Rising
UTMC Named Regions #1 Hospital
Terry D. Hinds, Jr., Ph.D.
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Assistant Professor Phone: (419) 383-4465
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Research Interests:
My current studies are on heme oxygenase (HO) regulation of obesity induced hypertension. Nutrient overload and genetic factors have led to a worldwide epidemic of obesity that is the underlying cause of diabetes, atherosclerosis and cardiovascular disease. Diet induced obesity results in elevated levels of glucose and fatty acids in liver, resulting in enhanced production of reactive oxygen species (ROS). The oxidative stress magnifies the adverse effects of obesity by inducing inflammation in liver, leading to non-alcoholic fatty liver disease (NAFLD). The onset of NAFLD has been linked to cardiovascular events by increasing levels of the proinflammatory markers interleukin-6 (IL-6) and C-reactive protein (CRP). CRP is an acute phase protein that is predominantly produced by exacerbated ROS in liver, resulting in secretion into blood, increasing the risk of hypertension and cardiovascular disease.
The heme oxygenase enzyme is functionally important for reducing ROS by increasing production of the antioxidant, bilirubin. Our studies show that increasing HO activity attenuates the development of NAFLD in obese mice by significantly increasing expression of the nuclear receptor, peroxisome proliferator-activated receptor alpha (PPARalpha). Induction of PPARalpha activity results in decreased CRP expression, as well as, increased expression of fibroblast growth factor 21 (FGF21), resulting in the reversal of hepatic steatosis, increased energy expenditure, and decreased body weight. My current studies have elucidated the HO-1-PPARalpha-FGF21 axis as a new signaling paradigm that can manage obesity induced NAFLD, resulting in the lowering of hypertension.
Patents:
• For: Methods and Compositions for Treating Dyslipidemia and Obesity using Protein
Phosphatase 5 as a Drug Target (2012).
Inventors: Terry D. Hinds, Jr. and Edwin R. Sanchez
*US Utility Patent
http://utoledo.technologypublisher.com/technology/11187
• For: Glucocorticoid Receptor Beta in Mice (2010).
Inventors: Terry D. Hinds, Jr. and Edwin R. Sanchez
*Provisional Patent
Licensing:
Resource: Mouse Glucocorticoid Receptor beta Polyclonal Antibody
Inventors: Terry D. Hinds, Jr. and Edwin R. Sanchez
http://utoledo.technologypublisher.com/technology/11366
Awards and Commendations:
2010 Selected for Oral Presentation in “Hot topics of Physiology”, Keystone Symposia, Nuclear Receptors: Signaling, Gene Regulation and Cancer, Keystone,
CO
2010 Cancer, Genetics, and Signaling (CGS) Group at the National Cancer Institute-Frederick.
Selected as one of the Top 10 at the NIH Graduate Student Research Festival (200 total)
2010 Abstract Award, Endocrine Society National Meeting, San Diego, CA
2009-10 Ruth L. Kirschstein National Research Service Award (NRSA), NIDDK, NIH
2008 Campden Research Scholarship Recipient
2001 Thinker of the Year Award Recipient, Civic Development Group
2001 Beta Beta Beta Biological Honor Society Research Scholarship Recipient
1996 Dow Chemical Academic Science Scholarship Recipient
Training:
• 2002 - B.S., Biology, Shawnee State University, Portsmouth, Ohio
• 2010 - Ph.D., Medical Sciences, Cardiovascular and Metabolic Diseases, University of Toledo, College of Medicine, Toledo, Ohio
Appointments:
• 2004 - Anatomy and Physiology I, Adjutant Instructor, Shawnee State University
• 2004 - Anatomy and Physiology II, Adjunct Instructor, Shawnee State University
• 2007 - Guest lecturer for Methods in Molecular Biology course, Medical University
of Ohio
• 2011 - Postdoctoral Fellow, Physiology & Pharmacology, University of Toledo
• 2012 - Instructor, Organ Systems course in Physiology & Pharmacology, University
of Toledo
• 2013 - Assistant Professor, Physiology & Pharmacology, University of Toledo
Representative Publications:
Luca Vanella, Komal Sodhi, Dong Hyun Kim, Nitin Puri, Mani Maheshwari, Terry D. Hinds, Jr., Lars Bellner, D. Goldstein, Stephen J. Peterson, Nader G. Abraham and Joseph Shapiro. Increased Heme-Oxygenase 1 Expression Diminished Adipocyte Differentiation and
Lipid Accumulation by Upregulation of the Canonical Wnt Signaling Cascade. Stem Cell Research and Therapy (2013). PMID:
Hinds, T. D. J., Stechschulte, L. A., Cash, H. A., Whisler, D., Banerjee, A., Yong, W., Khuder, S. S., Kaw, M. K., Shou, W., Najjar, S. M. & Sanchez, E. R. Protein phosphatase 5 mediates lipid metabolism through reciprocal control of glucocorticoid and PPAR{gamma} receptors. J Biol Chem (2011). PMID: 21994940.
Wuescher, L., Angevine, K., Hinds, T., Ramakrishnan, S., Najjar, S., and Mensah-Osman, E. Insulin regulates Menin expression, cytoplasmic localization and interaction with FOXO1. Am J Phys Endo & Met (2011). PMID: 21693693.
Chen, H., Yong, W., Hinds, T. D. J., Yang, Z., Zhou, Y., Sanchez, E. R. & Shou, W. Fkbp52 regulates androgen receptor transactivation activity and male urethra morphogenesis. J Biol Chem 285, 27776-27784 (2010). PMID: 20605780.
Hinds, T. D. J., Ramakrishnan, S., Cash, H. A., Stechschulte, L. A., Heinrich, G., Najjar, S. M. & Sanchez, E. R. Discovery of glucocorticoid receptor-beta in mice with a role in metabolism. Mol Endocrinol 24, 1715-1727 (2010). PMID: 20660300.
Periyasamy, S., Hinds, T. D., Shemshedini, L., Shou, W. & Sanchez, E. R. FKBP51 and Cyp40 are positive regulators of androgen-dependent prostate cancer cell growth and the targets of FK506 and cyclosporin A. Oncogene 29, 1691-1701 (2010). PMID: 20023700.
Warrier, M., Hinds, T. D. J., Ledford, K. J., Cash, H. A., Patel, P. R., Bowman, T. A., Stechschulte, L. A., Yong, W., Shou, W., Najjar, S. M. & Sanchez, E. R. Susceptibility to diet-induced hepatic steatosis and glucocorticoid resistance in FK506-binding protein 52-deficient mice. Endocrinology 151, 3225-3236 (2010). PMID: 20427484.
Wolf, I. M., Periyasamy, S., Hinds, T. D., Jr., Yong, W., Shou, W. & Sanchez, E. R. Targeted ablation reveals a novel role of FKBP52 in gene-specific regulation of glucocorticoid receptor transcriptional activity. J Steroid Biochem Mol Biol 113, 36-45 (2009). PMID: 19073255.
Banerjee, A., Periyasamy, S., Wolf, I. M., Hinds, T. D. J., Yong, W., Shou, W. & Sanchez, E. R. Control of glucocorticoid and progesterone receptor subcellular localization by the ligand-binding domain is mediated by distinct interactions with tetratricopeptide repeat proteins. Biochemistry 47, 10471-10480 (2008). PMID: 18771283.
Hinds, T. D., Jr. & Sanchez, E. R. Protein phosphatase 5. Int J Biochem Cell Biol 40(11), 2358-2362 (2008). PMID: 17951098.
E. Uldrich, R. Phipps, Hinds, Jr., Terry D. and E. H. Burns, Jr. 2004. Selective reduction of coliforms in constructed wetlands. In: Mitsch, W. J. and V. Bouchard (ed.), Olentangy River Wetland Research Park at The Ohio State University, Annual Report. Columbus, OH.
Hinds, Jr., Terry D., R. R. Brown, and E. H. Burns, Jr. 2002. Reduction of Fecal Coliform Levels in Two Constructed Wetlands at the Olentangy River Wetland Research Park. In: Mitsch, W. J. and V. Bouchard (ed.), Olentangy River Wetland Research Park at The Ohio State University, Annual Report. Columbus, OH.
