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Research Assistant Professor

Silvia Mabel Goicoechea 
Silvia Mabel Goicoechea

  

         Research Assistant Professor
         BO 3090 
         419.530.1991 
         Silvia.Goicoechea@utoledo.edu

 
 
Educational Background
   

B.S., Universidad Nacional de Mar del Plata, Argentina

PhD, Universidad Nacional de Mar del Plata, Argentina 

Postdoc, UNC Chapel Hill, North Carolina, USA

Research Interests
My research interests are focus on the remodeling of the cytoskeleton during the process of cell migration. Aberrant regulation of cell migration drives progression of many diseases, including cancer invasion and metastasis. In particular, my research is focus on the remodeling of extracellular matrix (ECM) that allows cancer cells to alter their microenvironment to clear space and create tracks along which cells can migrate more efficiently. To do that cells form actin-based subcellular structures termed invadopodiaor podosomes that are well-characterized as a specialized machinery for ECM degradation. Therefore, the fundamental mechanisms of cell migration and invasion are critical for our understanding of both basic biology and the pathology of disease. 
 
Publications

1- I'm coming to GEF you: Regulation of RhoGEFs during cell migration. Goicoechea SM, Awadia S, Garcia-Mata R. Cell Adh Migr. 2;8(4), 2014

2- Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in tumor-associated fibroblasts. Goicoechea SM, García-Mata R, Staub J, Valdivia A, Sharek L, McCulloch CAG, Hwang RF, Urrutia R, Yeh JJ, Kim HJ and Otey CA. Oncogene 6;33(10):1265-73, 2014

3- Structure and function of palladin's actin binding domain. Beck MR, Dixon RD, Goicoechea SM, Murphy GS, Brungardt JG, Beam MT, Srinath P, Patel J, Mohiuddin J, Otey CA, Campbell SL. J Mol Biol. 23;425(18):3325-37, 2013

4- The actin associated protein palladin is important for the early smooth muscle cell differentiation. Jin L, Gan Q, Zieba BJ, Goicoechea SM, Owens GK, Otey CA, Somlyo AV. PLoS One 22;5(9):e12823, 2010

5- Isoform-specific upregulation of palladin in human and murine pancreas tumors. Goicoechea SM, Bednarski B, Stack C, Cowan DW, Volmar K, Thorne L, Cukierman E, Rustgi AK, Brentnall T, Hwang RF, McCulloch CA, Yeh JJ, Bentrem DJ, Hochwald SN, Hingorani SR, Kim HJ, Otey CA. PLoS One 26;5(4):e10347, 2010.

6- Cytoplasmic Ig-domain proteins: Cytoskeletal regulators with a role in human disease. Otey CA, Dixon R, Stack C, Goicoechea SM. Cell Motil Cytoskeleton. 66(8):618-34, 2009

7- Roles of the small GTPases RhoA and Rac1 in cell behavior. Carol Otey, Silvia Goicoechea and Rafael Garcia-Mata. F1000 Biology Reports 1:4, 2009

8- Characterization of cortactin as an in vivo Protein Kinase D substrate: interdependence of sites and potentiation by Src. Line De Kimpe, Katrien Janssens, Rita Derua, Milena Armacki, Silvia Goicoechea, Carol Otey, Etienne Waelkens, Sandy Vandoninck, Jackie R. Vandenheede, Thomas Seufferlein, and Johan Van Lint. Cell. Signal. 21(2):253-63, 2009

9- Palladin contributes to invasive motility in human breast cancer cells. Goicoechea SM, Bednarski B, García-Mata R, Prentice-Dunn H, Kim HJ and Otey CA. Oncogene. 28(4):587-98, 2009

10- The role of palladin in actin organization and cell motility.Silvia Goicoechea, Daniel Arneman and Carol Otey. Eur J Cell Biol. 87(8-9):517-25, 2008

11- Palladin binds to Eps8 and enhances the formation of dorsal ruffles and podosomes in vascular smooth muscle cells. GoicoecheaSM, Arneman D, Disanza A, Garcia-Mata R, Scita G and Otey C. J. Cell Science 119(Pt 16):3316-24, 2006

12- Low density lipoprotein receptor-related protein is a calreticulin co-receptor that signals focal adhesion disassembly. A.W. Orr, C. Pedraza, M.A. Paller, C. Elzie, SM Goicoechea, D. Strickland, J. Murphy-Ullrich. J. Cell Biol. 161(6):1179-89, 2003

13- Anti-adhesive Activity of Thrombospondin is Mediated by The N-terminal Domain of Cell Surface Calreticulin. Goicoechea SM, Pallero MA, Eggleton P, Michalak M., Murphy-Ullrich JE. J Biol Chem. 277(40):37219-28, 2002

14- Nck-2 interacts with focal adhesion kinase and modulates cell motility. Goicoechea, SM; Tu, Y; Hua, Y; Chen, K; Shen, T-L; Guan, J-L; Wu, C. Int. J. Biochem. Cell. Biol. 1255:1-15, 2002

15- Thrombospondin mediates focal adhesion disassembly through interactions with cell surface calreticulin. Goicoechea SM, Orr WA, Pallero MA, Eggleton P, Murphy-Ullrich JE. J. Biol. Chem. 275(46):36358-68, 2000

16 - The LIM-only protein PINCH is a binding protein for the integrin-linked kinase (ILK). Tu, Y; Li, F; Goicoechea, SM; Wu, C, Molecular and Cellular Biology, 19(3):2425, 1999

17- Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression and tumorigenicity. Wu, C; Keightley, SY; Leung-Hegesteijn, CH; Radeva, G; Coppolino, M; Goicoechea, SM; McDonald, JA; Dedhar, S. J. Biol. Chem. 273(1):528-536, 1998

18- Influence of protein nutrition on calpain activity of mouse kidney: Modulation by calpastatin. Goicoechea, SM; Conde, RD. Mol. Cell. Biochem. 166 (1/2):95-99, 19

19- Estimation of ubiquitin and ubiquitin mRNA content in dark senescing wheat leaves. Pinedo, ML; Goicoechea, SM; Lamattina, L; Conde, RD. Biologia Plantarum, 38(3):321-328, 1996

20- Effect of dietary level of protein on the activity of mouse liver calpain. Goicoechea, SM; Tabares, L; Pucciarelli, MG; Sabas, ME; Conde, RD. Horm. Metab. Res. 26, 175-180, 1994

Book chapter:

Cell surface calreticulin-thrombospondin de-adhesive activity in Calreticulin in Health and Disease. SM Goicoechea and J.E.Murphy-Ullrich. In Calreticulin 2nd Edition. Ed. Paul Eggleton and Marek Michalak. Landes Bioscience, Georgetown, Texas (2002).

Last Updated: 6/26/15