Department of Chemistry and Biochemistry

Project Seed 2014:  Project Summaries University of Toledo Department of Chemistry

Dr. Jared Anderson Anderson webpage
Developing Extraction Methods for Removing Impurities from Active Pharmaceutical Ingredients
In the pharmaceutical industry today, the presence of genotoxic impurities in active pharmaceutical ingredients is of great concern. Governmental regulation authorities, such as the Food and Drug Administration, have strict levels in which these impurities can be present after synthesis of the drug component. In our laboratory, we seek new methods and techniques to selectively extract and remove these impurities. We utilize a number of extraction and separation techniques and the summer student will gain exposure to all of these as well as learn the importance of quality control and quality assurance as it is related to the purity of pharmaceutical drugs.
 
Dr. Amanda Bryant-Friedrich - Bryant-Friedrich webpage 
Synthesis of Indole Derivatives as Potential Treatments for Hepatitis C
The development of new treatments for Hepatitis C is very important for the world population.  This viral infection attacks the liver and is the leading cause of liver transplant.  Indole derivatives have been identified as potential treatments for the treatment of this viral infection.  This project will utilize a series of common organic reactions to synthesize these derivatives.  They will be purified and analyzed by the student participant.  The student will also be involved in the design of new modified substrates based on the outcomes obtained.

Dr. Dragan Isailovic - Isailovic webpage
Analysis of Biomolecules in Yeast Cells by MALDI-MS
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is a useful technique for the analysis of biomolecules, such as proteins, lipids, and metabolites, in microorganisms. In this project, MALDI-MS will be applied for the analyses of yeast cells. The project’s goal is to identify biomolecular profiles of yeast cells by combination of MALDI-MS and light microscopy. Analytical protocols will be developed for MALDI-MS analyses of biomolecules in whole cells and cellular extracts.  The results of this project will enhance our knowledge about biomolecules in yeast cells and facilitate further applications of MALDI-MS for the analyses of microorganisms.

Dr. Cora Lind-Kovacs - Lind-Kovacs webpage
Synthesis of Polymer/Inorganic Composites
Composite materials can combine attractive properties of several compounds. For example, carbon fiber composites have been introduced as lightweight and strong materials in applications that used to require steel (golf clubs, airplanes). The combination of polymers with inorganic filler materials is especially attractive, as the many beneficial properties of polymers can be augmented by mechanical strength or other value-added electronic or optical properties. Our group is exploring methods for combining inorganic oxides that are semiconductors or have special expansion properties with polymers, with the goal of developing simple and reproducible methods for production of homogeneous composites.

Dr. Jianglong Zhu - Zhu webpage
Stereoselective Synthesis of S-linked 2-Deoxy Glycosides
2-Deoxy sugars exist in a wide range of potent natural antitumor antibiotics and play critical role in their biological activity as well as stability and solubility. Despite the significance of 2-deoxy sugar subunits, the glycosidic linkage of 2-deoxy sugars is labile and can be readily hydrolyzed. In this project, we plan to prepare “non-hydrolyzable” S-linked 2-deoxy sugars for evaluating their structure and activity relationship (SAR).

 

For further information contact Dr. Jon Kirchhoff, 419-530-1515, jon.kirchhoff@utoledo.edu

Dept News

Faculty News

Student News

  • Lorenza Favrot defended her Ph.D. dissertation
  • Tien Ho defended his Ph.D. dissertation
  • Nicholas Zeringo defended his Ph.D. Disseration
  • Rajvinder Kaur defended her M.S. Thesis
  • Kevin Clark has been awarded a University Fellowship - Apr 2014
Last Updated: 6/26/15