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- Colloquium - Oct 4 William Roush - Scripps Research Inst.
- Colloquium - Oct 16 Raziya Shaik - Ph.D. Defense
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Faculty News
- Drs. Ronning and Sucheck awarded a National Institutes of Health grant
- Andy Jorgensen wins ACS Environmental Award
- Andy Jorgensen is a 2012 ACS Fellow
- Max Funk earned the 2012 Excellence in Professional Service Award
- Jared Anderson earned the 2012 Outstanding Research Award
- Jianglong Zhu awarded National Science Foundation grant
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- Terry Bigioni awarded National Science Foundation grant
- Jianglong Zhu awarded an Ohio Cancer Research grant
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- Peter Andreana awarded National Institutes of Health grant
Student News
- Yaohua Han successfully defended his Ph.D. dissertation
- Stephen Zano successfully defended his Ph.D. dissertation
- Manish Joshi successfully defended his Ph.D. dissertation
- Nicholas Amato successfully defended his Ph.D. dissertation
- Kate Guo successfully defended her Ph.D. dissertation
- Lorenza Favrot won a best poster award at the ASBMB meeting in Boston
Project Seed 2013: Project Summaries University of Toledo Department of Chemistry
Dr. Jared Anderson - Anderson webpage
Developing Extraction Methods for Removing Impurities from Active Pharmaceutical Ingredients
In the pharmaceutical industry today, the presence of genotoxic impurities in active pharmaceutical ingredients is of great concern. Governmental regulation authorities, such as the Food and Drug Administration, have strict levels in which these impurities can be present after synthesis of the drug component. In our laboratory, we seek new methods and techniques to selectively extract and remove these impurities. We utilize a number of extraction and separation techniques and the summer student will gain exposure to all of these as well as learn the importance of quality control and quality assurance as it is related to the purity of pharmaceutical drugs.
Developing Extraction Methods for Removing Impurities from Active Pharmaceutical Ingredients
In the pharmaceutical industry today, the presence of genotoxic impurities in active pharmaceutical ingredients is of great concern. Governmental regulation authorities, such as the Food and Drug Administration, have strict levels in which these impurities can be present after synthesis of the drug component. In our laboratory, we seek new methods and techniques to selectively extract and remove these impurities. We utilize a number of extraction and separation techniques and the summer student will gain exposure to all of these as well as learn the importance of quality control and quality assurance as it is related to the purity of pharmaceutical drugs.
Dr. Wendell Griffith - Griffith webpage
Protein sequencing by mass spectrometry
Hemoglobin is one of the most important proteins to life as it is responsible for transporting oxygen from the lungs throughout the body to all tissues and organs. In our laboratory we study the evolution of hemoglobin and its interactions with other proteins, for which sequence information is important. We obtain hemoglobin samples from a variety of animals through collaboration with the Toledo Zoo. Each of these hemoglobin samples are sequenced using a number of simple analytical methods including chromatography, protein chemistry and mass spectrometry. This project has served to enhance the research experiences of over a dozen high school and undergraduate students.
Dr. Dragan Isailovic - Isailovic webpage
Analysis of proteins in cells using light microscopy and mass spectrometry
Analysis of proteins in biological cells is essential for elucidation of important biological processes including cell growth and cell-cell interactions. The student working on this project will learn about bioanalytical techniques that are used to selectively label yeast cells and analyze their protein content by fluorescence microscopy and mass spectrometry (MS). The project will involve selective labeling of proteins and glycoproteins in cells, imaging of cells by light microscopy, and consequent separation of proteins by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) followed by protein identification by matrix-assisted laser desorption/ionization (MALDI)-MS.
Dr. Cora Lind-Kovacs - Lind-Kovacs webpage
Negative thermal expansion materials
Most materials expand when heated, but negative thermal expansion (NTE) materials shrink. These compounds are of interest for controlled thermal expansion composites. Our group has prepared a number of NTE compounds, some for basic studies, some for incorporation into controlled thermal expansion composites. The summer student will work closely with graduate students in the group to explore the influence of synthetic variables on sample purity and particle morphology. Samples will be characterized by powder X-ray diffraction, thermal analysis, and electron microscopy.
Most materials expand when heated, but negative thermal expansion (NTE) materials shrink. These compounds are of interest for controlled thermal expansion composites. Our group has prepared a number of NTE compounds, some for basic studies, some for incorporation into controlled thermal expansion composites. The summer student will work closely with graduate students in the group to explore the influence of synthetic variables on sample purity and particle morphology. Samples will be characterized by powder X-ray diffraction, thermal analysis, and electron microscopy.
Development of Novel Antibiotics
This project involves the use of standard molecular biology techniques to clone and express genes that encode for our antibiotic target enzyme obtained from a variety of different microorganisms.
This project involves the use of standard molecular biology techniques to clone and express genes that encode for our antibiotic target enzyme obtained from a variety of different microorganisms.
Dr. Jianglong Zhu - Zhu webpage
Stereoselective Synthesis of 2-Deoxy Glycosides in Antitumor Antibiotics
2-Deoxy sugars are a class of biologically important carbohydrates that exist in a wide range of potent natural antitumor antibiotics and play critical role in their biological activity as well as stability and solubility. In this project, we plan to develop and apply a new method in stereoselective synthesis of 2-deoxy sugar subunits of select potent antitumor antibiotics.
