Department of Chemistry and Biochemistry


  • Inactivation of the Mycobacterium tuberculosis Antigen 85 complex by covalent, allosteric inhibitors. Lorenza Favrot, Daniel H. Lajiness, Donald R. Ronning. J Biol Chem (2014) jbc.M114.582445.
  • Synthesis of a C-phosphonate mimic of maltose-1-phosphate and inhibition studies on Mycobacterium tuberculosis GlgE. Sri Kumar Veleti, Jared J. Lindenberger, Donald R. Ronning, Steven J. Sucheck. Bioorg Med Chem. 2014 22(4):1404-11.
  • The inhibition mechanism of Mycobacterium tuberculosis Antigen 85 by ebselen. Lorenza Favrot, Anna E. Grzegorzewicz, Daniel H. Lajiness, Rachel K. Marvin, Julie Boucau, Dragan Isailovic, Mary Jackson, Donald R. Ronning. Nat. Commun. (2013) 4:2748 doi: 10.1038/ncomms3748.
  • Zafirlukast inhibits complexation of Lsr2 with DNA and growth of Mycobacterium tuberculosis. Lucile Pinault, Jeong-Sun Han, Choong-min Kang, Jimmy Franco, Donald R. Ronning. Antimicrobial Agents and Chemotherapy. Antimicrob. Agents Chemother. (2013) 57: 2134-40.
  • Ionic liquids as solvents for in situ dispersive liquid-liquid microextraction of DNA. Tianhao Li, Manishkumar D. Joshi, Donald R. Ronning, Anderson JL. J Chromatogr A. (2013) 1272: 8-14.
  • Diaa A. Ibrahim, Julie Boucau, Daniel H. Lajiness, Sri Kumar Veleti, Kevin R. Trabbic, Samuel S. Adams, Donald R. Ronning, and Steven J. Sucheck. Design, Synthesis, and X-ray Analysis of a Glycoconjugate Bound to Mycobacterium tuberculosis Antigen 85C. Bioconjug Chem. 2012 23(12): 2403-16.
  • Vidhi Mishra, Donald R. Ronning. Crystal Structures of the Helicobacter pylori MTAN Enzyme Reveal Specific Interactions between S-Adenosylhomocysteine and the 5'-Alkylthio Binding Subsite. Biochemistry, (2012) 51: 9763–9772.
  • Lorenza Favrot, Donald R. Ronning. Targeting the mycobacterial envelope for tuberculosis drug development. Expert Rev Anti Infect Ther. 2012 10(9): 1023-36.
  • Donald Ronning, Natalie Iacopelli, Vidhi Mishra. Enzyme-ligand interactions that drive active site rearrangements in the Helicobacter pylori 5’-methylthioadenosine/S-adenosylhomocysteine nucleosidase. Protein Sci. 2010, 19(12):2498-2510.
  • Francis Umesiri, Aditya Sanki, Julie Boucau, Donald Ronning, Steve Sucheck. Recent advances toward the inhibition of mAG and LAM synthesis in Mycobacterium tuberculosis. Med. Res. Rev. 2010, 30(2):290-326.
  • Aditya Sanki, Julie Boucau, Francis Umesiri, Donald Ronning, Steve Sucheck. Design, synthesis and biological evaluation of sugar-derived esters, alpha-ketoesters and alpha-ketoamides as inhibitors for Mycobacterium tuberculosis antigen 85C. Mol Biosyst. 2009, 5(9):945-956.
  • Aditya Sanki, Julie Boucau, Donald Ronning, Steve Sucheck. Antigen 85C-Mediated acyl-transfer between synthetic acyl donors and fragments of the arabinan. Glycoconjugate J. 2009, 26(5): 589-596.
  • Julie Boucau, Aditya Sanki, Brad Voss, Steve Sucheck, Donald Ronning. A Coupled assay measuring M. tuberculosis antigen 85C activity. Anal. Biochem. 2009, 385(1):120-127.
  • Aditya Sanki, Julie Boucau, Parajat Srivastava, Samual Adams, Donald Ronning, Steve Sucheck. Synthesis of methyl 5-S-alkyl-5-thio-D-arabinofuranosides and evaluation of their antimycobacterial activity. Bioorg. Med. Chem. 2008 May 15;16(10):5672-82.
  • Orsolya Barabas, Donald Ronning, Catherine Guynet, Alison B Hickman, Bao Ton-Hoang, Michael Chandler, Fred Dyda. Mechanism of IS200/IS605 Family DNA Transposases: Activation and Transposon-Directed Target Site Selection. Cell (2008) 132, 208-220.
  • Donald Ronning, Catherine Guynet, Bao Ton-Hoang, Zhanita Perez, Rodolfo Ghirlando, Michael Chandler, Fred Dyda. Active site sharing and subterminal hairpin recognition in a new class of DNA transposases. Mol. Cell (2005) 20, 143-154.
  • Bao Ton-Hoang, Catherine Guynet, Donald Ronning, Brigitte Cointin-Marty, Fred Dyda, Michael Chandler. Transposition of ISHp608, member of an unusual family of bacterial Insertion sequences. EMBO J. (2005) 24, 3325-3338.
  • Christina Bradley, Donald Ronning, Rodolfo Ghirlando, Robert Craigie, Fred Dyda. Structural basis for DNA bridging by barrier-to-autointegration factor. Nat. Struct. Mol. Biol. (2005) 12, 935-936.
  • Kuppan Gokulan, Sangeeta Khare, Donald Ronning, Scott Linthicum, James Sacchettini, Bernhard Rupp. Cocrystal structures of NC6.8 Fab identify key interactions for high potency sweetener recognition: Implications for the design of synthetic sweeteners. Biochemistry (2005) 44, 9889-9898.
  • Donald Ronning, Ying Li, Zhanita Perez, Phillip Ross, Alison B Hickman, Nancy Craig, Fred Dyda. The carboxy-terminal portion of TnsC activates the Tn7 transposase through a specific interaction with TnsA. EMBO J. (2004) 23, 2972–2981.
  • Donald Ronning, Varalakshmi Vissa, Gurdyal Besra, John Belisle, James Sacchettini. Mycobacterium tuberculosis antigen 85A and 85C structures confirm binding orientation and conserved substrate specificity. J. Biol. Chem. (2004) 279, 36771-36777.
  • Alison B Hickman, Donald Ronning, Zhanita Perez, Robert Kotin, Fred Dyda. The nuclease domain of Adeno-Associated Virus Rep coordinates replication initiation using two distinct DNA recognition interfaces. Mol. Cell. (2004) 13, 403-414.
  • Vivek Sharma, Arulandu Arockiasamy, Donald Ronning, Christos Savva, Andreas Holzenburg, Miriam Braunstein, William Jacobs Jr, James Sacchettini. Crystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPase. Proc. Natl. Acad. Sci. U. S. A. (2003) 100, 2243-2248.
  • Michelle Riley-Lovingshimer, Donald Ronning, James Sacchettini, Gregory Reinhart. Reversible ligand-induced dissociation of a tryptophan-shift mutant of phosphofructokinase from Bacillus stearothermophilus. Biochemistry (2002) 41, 12967-12974.
  • Alison B Hickman, Donald Ronning, Robert Kotin, Fred Dyda. Structural unity among viral origin binding proteins: crystal structure of the nuclease domain of adeno-associated virus Rep. Mol. Cell. (2002) 10, 327-337.
  • Donald Ronning, Thomas Klabunde, Gurdyal Besra, Varalakshmi Vissa, John Belisle, James Sacchettini. Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines. Nat. Struct. Biol. (2000) 7, 141-146.
  • Ronan O’Hagen, Nicole Schreiber-Agus, Ken Chen, Gregory David, Jeffrey Engelman, Richard Schwab, Leila Alland, Cole Thomson, Donald Ronning, James Sacchettini, Paul Meltzer, Ronald DePinho. Gene-target recognition among members of the myc superfamily and implications for oncogenesis. Nat. Genet. (2000) 24, 113-119. 
Last Updated: 6/26/15