Department of Neurology

Thyagarajan Subramanian, M.D., MBA

Senior Associate Dean for Research
Professor

Special Interests

Parkinson's Disease
Lewy-body Dementia
Parkinson's Plus Disorders
Huntington's Disease
Tourette's Syndrome
Tardive Dyskinesias
Post-polio Syndrome

Education

Undergraduate:  Malabar Christian College/Calicut University, Calicut, India 1980
M.D.:  Calicut Medical College, Calicut University, Calicut, India 1985

Professional Appointments

Full Member, Neurology Department Promotion and Tenure Committee 2010-current
Member, Scientific Review Committee, PSUHMC, Penn State College of Medicine, 2008-current
Member, Institutional Biosafety Committee, Penn State Hershey Medical Center, 2007-current
Publications Committee Member, Parkinson’s Study Group (PSG), 2018-2022
Executive Committee Member, Association of Indian Neurologists in America (AINA)
IAPRD Industry Relations Committee Member, 2019
Co-Chair INT-15 Session on Clinical Trials, Clearwater Beach, 2018
President, Central Pennsylvania Chapter of the Society for Neuroscience 2012-2020

Certifications

American Board of Psychiatry and Neurology, 1996
Educational Council for Foreign Medical Graduates (ECFMG) Permanent Certification

Society Memberships

International Association of Parkinson's Disease and Related Disorders
Society for Neuroscience
American Academy of Neurology
American Society for Neural Transplantation and Repair (Elected Fellow)
Movement Disorders Society
American Neurological Association
American Academy of Neurology
Association of Indian Neurologists in American

Awards and Honors

Member, Parkinson Study Group, 2000-current
Chairperson, USA Brain Bee Championship, Hershey, PA, 2019
Invited Speaker, Indian Academy of Neurology 25th Annual Meeting Chennai, India, 2017
Department of Neurology Teacher of the Year, 2017
Department of Neurology Teacher of the Year, 2016
Cornelius Award, Arms Around Communities, 2011
Tenured Professor, Penn State University, 2008
Pennsylvania Tobacco Settlement Fund Research Award, 2006-2010
PSU Physician Scientist Award, Penn State University, 2006-2009
Elected member, World Federation of Neurology, 2005
First Dr. S. Kalyanaraman Oration Award, Neurological Institute of Madras Medical College, Chennai, India, 2002
International Research Award, Parkinson's Disease Foundation, 1999
Elected Fellow, American Society for Neural Transplantation and Repair, 1997

Editorial

Ad hoc reviewer
Experimental Neurology
Journal of Comparative Neurology
Journal of Neuroscience Methods
Brain Research
Pharmacology
Biochemistry and Behavior
Neuroscience and Behavioral Reviews
Brain
Neurology, Experimental Eye Research
Annals of Neurology
Cell Transplantation
Neuroscience Research
J Neurophysiology
Brain Research Bulletin
Plos 1
Parkinson’s Disease and Related Disorders
Frontiers in Neurology
Journal of Neuroscience

selected Publications

Papers
Manfredsson, F. P., Subramanian, T., Boulis, N., Wakeman, D. R., & Mandel, R. J. (2020). The future of GDNF in Parkinson’s Disease. Frontiers in Aging Neuroscience, 12, 388.

Parkinson Study Group STEADY-PD III Investigators:Tanya SimuniDavid OakesKevin BiglanWendy R. GalpernRobert HauserKaren HodgemanElise KaysonDaniel KinelAnthony LangCodrin LunguSaloni SharmaIra ShoulsonChristopher G. TarolliDalton J. SurmeierCharles VenutoRobert HollowayKatie KompolitiIrene RichardRuth SchneiderMarian EvattVanessa HinsonAlok SahayIrene LitvanEris S. FarbmanBrad RacetteKaren BlindauerKaren ThomasCheryl WaterConnie MarrasCorneliu C. LucaAlbert HungAndre DeikDeborah BurkeCindy ZadikoffMichel PanissetMarcie RabinMatthew BrodskyKelly MillsAlexander ShtilbansEra HanspalChadwick W. ChristineThyagarajan Subramanian, Mya Caryn SchiessRajeev KumarKelvin L. ChouBinit ShahMark GuttmanHolly ShillJohn SlevinJohn L. GoudreauAriane ParkJohn BertoniMarie H. Saint-HilaireNatividad StoverCamila AquinoDavid ShprecherAnwar AhmedLisa ShulmanSotirios A. ParashosStephen LeePaul TuiteMelanie LangloisFabio DanisiPinky AgarwalTiago MestreDavid RussellDaniel TruongNeal HermanowiczRichard ZweigOksana SuchowerskyJustyna R. SarnaG. Webster RossLucia BlasucciCarol ZimmermanShonna JenkinsErin NeefusMary PecoraroLynn WheelerLisa RichardsonAmber RatelJulie RacioppaGrace BwalaSuzanne ReichweinClaudia RochaKaren WilliamsKelli KeithEmily CarmanSharon EvansAaron DaleyKala VenkiteswaranVicki EphronKaren OrtizAngela StovallMolly GoddardRenee WagnerKatherine AmbrogiCarolyn PetersonCathi A. ThomasMichelle CinesPatricia EdePauline LeBlancSusan RolandelliBryan LewisAnna FierroBreanna ChewJeanne McGeePaul McCannMichael MatwichynaArthur WattsMichael McDermottShirley EberlyBrittany GrecoSusan Henderson, Jillian Lowell, Andrew Siderowf, Rick Chappell, Jay Phillips, Kapil D. Sethi, William B. White, Isradipine Versus Placebo in Early Parkinson Disease: A Randomized Trial. Ann Intern Med. 2020. Epub 2020/04/01. doi: 10.7326/M19-2534. PubMed PMID: 32227247Parkinson Study Group STEADY-PD III Investigators:Tanya SimuniDavid OakesKevin BiglanWendy R. GalpernRobert HauserKaren HodgemanElise KaysonDaniel KinelAnthony LangCodrin LunguSaloni SharmaIra ShoulsonChristopher G. TarolliDalton J. SurmeierCharles VenutoRobert HollowayKatie KompolitiIrene RichardRuth SchneiderMarian EvattVanessa HinsonAlok SahayIrene LitvanEris S. FarbmanBrad RacetteKaren BlindauerKaren ThomasCheryl WaterConnie MarrasCorneliu C. LucaAlbert HungAndre DeikDeborah BurkeCindy ZadikoffMichel PanissetMarcie RabinMatthew BrodskyKelly MillsAlexander ShtilbansEra HanspalChadwick W. ChristineThyagarajan Subramanian, Mya Caryn SchiessRajeev KumarKelvin L. ChouBinit ShahMark GuttmanHolly ShillJohn SlevinJohn L. GoudreauAriane ParkJohn BertoniMarie H. Saint-HilaireNatividad StoverCamila AquinoDavid ShprecherAnwar AhmedLisa ShulmanSotirios A. ParashosStephen LeePaul TuiteMelanie LangloisFabio DanisiPinky AgarwalTiago MestreDavid RussellDaniel TruongNeal HermanowiczRichard ZweigOksana SuchowerskyJustyna R. SarnaG. Webster RossLucia BlasucciCarol ZimmermanShonna JenkinsErin NeefusMary PecoraroLynn WheelerLisa RichardsonAmber RatelJulie RacioppaGrace BwalaSuzanne ReichweinClaudia RochaKaren WilliamsKelli KeithEmily CarmanSharon EvansAaron DaleyKala VenkiteswaranVicki EphronKaren OrtizAngela StovallMolly GoddardRenee WagnerKatherine AmbrogiCarolyn PetersonCathi A. ThomasMichelle CinesPatricia EdePauline LeBlancSusan RolandelliBryan LewisAnna FierroBreanna ChewJeanne McGeePaul McCannMichael MatwichynaArthur WattsMichael McDermottShirley EberlyBrittany GrecoSusan Henderson, Jillian Lowell, Andrew Siderowf, Rick Chappell, Jay Phillips, Kapil D. Sethi, William B. White, Isradipine Versus Placebo in Early Parkinson Disease: A Randomized Trial. Ann Intern Med. 2020. Epub 2020/04/01. doi: 10.7326/M19-2534. PubMed PMID: 32227247.

Iyer V, Vo Q, Mell A, Chinniah S, Zenerovitz A, Venkiteswaran K, Kunselman AR, Fang J, Subramanian T. Acute levodopa dosing around-the-clock ameliorates REM sleep without atonia in hemiparkinsonian rats. NPJ Parkinsons Dis. 2019;5:27.

Epub 2019/12/10. doi: 10.1038/s41531-019-0096-2. PubMed PMID: 31815176; PMCID: PMC6884572.
Chalia M, Subramanian T. Type 2 Diabetes Presenting With Persistent Chorea. JAMA Neurol. Published online December 21, 2018. doi:10.1001/jamaneurol.2018.4089.

Anselmi L, Bove C, Coleman FH, Le K, Subramanian MP, Venkiteswaran K, Subramanian T, Travagli RA. Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat. npj Parkinson's Disease. 2018;4(1):30. doi: 10.1038/s41531-018-0066-0.

Venkiteswaran K, Subramanian T, Sue-Grigson P (2016) Commentary on - Human Embryonic Retinal Pigment Epithelial (RPE) Cell Transplants for Chronic Refractory Cocaine Addiction. Health Care: Current Reviews 4: 165. doi: 10.4172/2375-4273.1000165.

Books

Gilmour, TP. (Thesis co-supervised by Jenkins, KW. and Subramanian, T.) Signal Processing Applications to Electrophysiology of Continuous Dopaminergic Stimulation Therapy in Preclinical Parkinson’s Disease Models, PSU Press, May 2012.

Lieu, CA.  (Thesis supervisior: Subramanian, T.) THE ROLE OF INTERHEMISPHERIC PATHWAYS IN PARKINSON’S DISEASE AND DRUG-INDUCED DYSKINESIAS, PSU Press, Dec 2011.

Ramachandra, R., Subramanian, T., Atlas of Neonatal Rat Brain, 2010. ISBN: 978-1-4398-2, CRC Press, pp.250.

Book Chapters

Kala Venkiteswaran, Vikram Shivkumar and Thyagarajan Subramanian,  “Early Parkinson’s disease:Essentials of Diagnosis and Management”, in Practice Pearls in Neurology – Series 3. Ed. Kesavamurthy B, Vasudevan D, Srinivasan AV, Jaypee Brothers Medical Publishers (P) Ltd. 2020. ISBN 978-93-89188-50-9.

Madhav Thambisetty, Nestor Galvez-Jimenez, and Thyagarajan Subramanian, “Advances in the treatment of Dementia”, in Imaging of Neurodegenerative Disorders, Ed. Sangam Kanekar, Thieme Publishers, 2015.

Thyagarajan Subramanian, Kala Venkiteswaran and Elisabeth Lucassen, “Secondary Parkinsonism”, in Imaging of Neurodegenerative Disorders, Ed. Sangam Kanekar, Thieme Publishers, 2015.

Last Updated: 6/27/22