Robert E. Mrak, M.D., Ph.D.

Robert E. Mrak, MD, PhD

Professor and Chairman

Department of Pathology
College of Medicine and Life Sciences

University of Toledo Health Sciences Campus, MS #1090
3000 Arlington Avenue
Toledo, Ohio 43614-2598
Phone:  419-383-3469
Fax:  419-383-3066

Medical Education and Training:

  • M.D. University of California at Davis
  • Ph.D. University of California at Davis
  • Resident in Anatomic Pathology, Vanderbilt University Affiliated Hospitals
  • Postdoctoral Fellow in Pathology and in Molecular Biology, Vanderbilt University

Extramural Activity:

Board Certification:

  • American Board of Pathology, Anatomic Pathology
  • American Board of Pathology, Neuropathology

Clinical Interests:

  • Program Director, pathology residency program
  • Program Director, pathologists' assistant program
  • Surgical neuropathology
  • Autopsy, and autopsy neuropathology
  • Neuropathology of dementia
  • Diagnostic nerve and muscle biopsies

Research Interests:

Glial inflammatory processes in chronic neurodegenerative diseases

Representative recent publications:

(find a complete list here)

    Thal DR, Papassotiropoulos A, Saido TC, Griffin WST, Mrak RE, Kölsch H, Tredici KD, Attems J, Ghebremedhin E:  Capillary cerebral amyloid angiopathy identifies a distinct APOE e4-associated subtype of sporadic Alzheimer’s disease.  Acta Neuropathol 120: 169-183, 2010.
    Funk KE, Mrak RE, Kuret J: Granulovacuolar degeneration bodies of Alzheimer’s disease resemble late-stage autophagic organelles. Neuropathol Applied Neurobiol 37:295-306, 2011.
    Liu L, Aboud O, Jones RA, Mrak RE, Griffin WST, Barger SW: Apolipoprotein E expression is elevated by interleukin 1 and other interleukin 1-induced factors. J Neuroinflamm 8:175, 2012.
    Aboud O, Mrak RE, Boop F, Griffin WST: Apolipoprotein epsilon3 alleles are associated with indicators of neuronal resilience. BMC Medicine 10:35, 2012.  
    Mrak RE. Microglia in Alzheimer brain: a neuropathological perspective [Invited review]. Int J Alzheimer Dis 2012:165021.
    Aboud O, Mrak RE, Boop FA, Griffin ST. Epilepsy: neuroinflammation, neurodegeneration, and Apolipoprotein E genotype. Acta Neuropathologica Commun 1:41, 2013
   Thal DR, von Arnim C, Griffin WST, Yamaguchi H, Mrak RE, Attems J, Upadhaya AR.  Pathology of clinical and pre-clinical Alzheimer’s disease.  Eur Arch Psych Clin Neurosci 263 (Suppl 2):S137-145, 2013
   Chen Y, Neve RN, ZHeng H, Griffin WTS, Barger SW, Mrak RE.  Cycle on wheels:  Is APP key to the AppBp1 pathway?  Austin Alzh Parkinson Dis 1(2):7, 2014.
   Thal DR, von Arnim CAF, Griffin WST, Mrak RE, Walker L, Attems J, Arzberger T.  Frontotemporal lobar degeneration FTLD-tau: preclinical lesions, vascular, and Alzheimer-related co-pathologies.  J Neural Transm 122:1007-18, 2015
   Zawada MW, Mrak RE, Biedermann J, Palmer QD, Gentleman SM, Aboud O, Griffin W.  Loss of angiotensin II receptor expression in dopamine neurons in Parkinson’s disease correlates with pathological progression and is accompanied by increases in Nox4- and 8-OH guanosine-related nucleic acid oxidation and caspase-3 activation. Acta Neuropathologica Communications 3:9, 2015
   Aboud O, Parcon PA, DeWall M, Liu L, Mrak RE, Griffin ST. Aging, Alzheimer’s, and APOE genotype influence the expression and neuronal distribution patterns of microtubule motor protein dynactin-P50.  Front Cell Neurosci 9:103, 2015
Mrak RE, Angtuaco EJC:  Atrophy of the cerebrum, deep gray matter, cerebellum, brainstem, and motor system.  In:  Gokden M, Kumar M (Eds):  Neuropathologic and Neuroradiologic Correlations:  A Differential Diagnostic Text and Atlas.  Cambridge University Press, Cambridge, U.K., in press 2016.


Last Updated: 11/28/17