Department of Pharmacology and Experimental Therapeutics

Surya Nauli, Ph.D.

 

Vice Chair, Department of Pharmacology
Associate Professor of Pharmacology

Phone: 419.383.1921
FAX: 419.383.1909
Frederic and Mary Wolfe Center 282D
Surya.Nauli@utoledo.edu

Education

B.S.

Minnesota State University, Biotechnology & Chemistry

Ph.D.

Loma Linda University, Pharmacology 

NIH Fellow Harvard Medical School, Cilia Biology

Research Interests

  • Cilia Biology
  • Cardiovascular Disease
  • Polycystic Kidney Disease

Selected Publications

Nauli SM, Kawanabe Y, Kaminski JJ, Pearce WJ, Ingber DE, Zhou J.  Endothelial cilia are fluid-shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1.  Circulation. 2008 Mar 4;117(9):1161-71.

AbouAlaiwi WA, Takahashi M, Mell BR, Jones TJ, Ratnam S, Kolb RJ, Nauli SM.  Ciliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades.  Circ Res. 2009 Apr 10;104(7):860-9.

AbouAlaiwi WA, Ratnam S, Booth RL, Shah JV, Nauli SM.  Endothelial cells from humans and mice with polycystic kidney disease are characterized by polyploidy and chromosome segregation defects through survivin down-regulation.  Hum Mol Genet. 2011 Jan 15;20(2):354-67.

Nauli SM.  Editorial Focus:  An ACE inhibitor improves vascular outcomes in a PKD model.  Am J Physiol Renal Physiol. 2011 Nov;301(5):F958.

Nauli SM, Jin X, AbouAlaiwi WA, El-Jouni W, Su X, Zhou J.  Non-motile primary cilia as fluid shear stress mechanosensors.  Methods Enzymol. 2013;525:1-20.

Jin X, Mohieldin AM, Muntean BS, Green JA, Shah JV, Mykytyn K, Nauli SM.  Cilioplasm is a cellular compartment for calcium signaling in response to mechanical and chemical stimuli.  Cell Mol Life Sci. 2013 [In Press]

AbouAlaiwi WA, Muntean BS, Ratnam S, Joe B, Liu L, Booth RL, Rodriguez I, Herbert BS, Bacallao RL, Fruttiger M, Mak TW, Zhou J, Nauli SM.  Survivin-induced abnormal ploidy contributes to cystic kidney and aneurysm formation.  Circulation. 2014 Feb 11;129(6):660-72.

Last Updated: 6/26/15