Department of Cancer Biology

Saori Furuta, Ph.D.

Saori Furuta, Ph.D.
Associate Professor  
Cancer Biology
saori.furuta@utoledo.edu


EDUCATION:

B.S. 1999 Biochemistry University of California, Riverside
M.S. 2001 Chemistry & Biochemistry California State University, Los Angeles
Ph.D. 2007 Biological Chemistry  University of California, Irvine
Post-Doc 2007-2014 Life Sciences Division Lawrence Berkeley National Laboratory


RESEARCH INTERESTS


Over 300,000 new cases of breast cancer are diagnosed in the U.S. each year, affecting 1 in 8 women in their lifetime.   Despite the recent advances in diagnostic tools, breast cancer mortality rate has only declined slowly, justifying the urgent need for a better diagnostic marker and treatment modality.  My long-term research interest is to investigate how aberrant arginine metabolism influences different components of tissue/tumor microenvironment, and how such havoc leads to carcinogenesis, drug resistance and immunosuppression.  I am also investigating whether normalizing arginine metabolism could boost the gut microbiome and train the innate immunity to prevent breast cancer formation.

FUNDING:

Ongoing Research
Support

R01CA248304, National Cancer Institute
3/2020 - 2/2025
Normalizing arginine metabolism with sepiapterin for immunostimulatory-shift of HER2+ breast cancer
Role:  PI

1R15CA238894-01A1
12/2019-11/2022
Understanding and targeting MELK overexpression in breast cancer and therapeutic efficacy of its inhibition
Role:  PI

American Cancer Society Research Scholar Award
01/2019-12/2022
Role of reduction of nitric oxide in formation of precancerous breast lesions
Role:  PI

Completed Research Support

Medical Research Society Grant - University of Toledo
6/2018-6/2019
Role of reduction of nitric oxide in formation of precancerous breast lesions
Role:  PI

Ohio Cancer Research Society
7/2017-6/2019
Role of nitric oxide in regulating the extracellular matrix in the breast
Role:  PI

R01CA064786, National Institutes of Health (PI, M.J. Bissel)
Definition of microenvironment in breast cancer
2008-2015
Role: Postdoctoral Associate

W81XWH-05-1-0322, Department of Defense
Roles of breast cancer susceptibility genes BRCA's in mammary epithelial cell differentiation
2005-2008
Role:  PI


PUBLICATIONS:

     PUBMED


STUDENT OPENINGS:   
Not currently accepting students


 

Last Updated: 11/9/21