Department of Chemistry and Biochemistry

Andreana Group Publications

Andreana Research Group Publications Webpage

PATENT:  Monoclonal IgM Antibodies from Entirely Carbohydrate Constructs (PCT/US2017/052169).

55. Kleski, K. A.; Andreana, P. R. (2019) Developments in CRM197 Glycoconjugates for Anticancer Vaccines.  American Journal of Biomedical Sciences (PI).

54. Hossain, F.; Andreana, P. R. (2019) Developments in Carbohydrate-Based Cancer Therapeutics. Pharmaceuticals 12: 84. (PI).

53.  Hohol, R. E.; Arcure, H.; Witczak, Z.; Bielski, R.; Kirschbaum, K.; Andreana, P.; Mencer, D. E.  (2018)  One-pot synthesis of carbohydrate exo-cyclic enones and hemiketals with 6,8-dioxabicyclo-[3.2.1]octane moieties. Serendipitous formation of a spironolactone when 2-pyridinecarboxaldehyde is used as the reactant. Part II  Tetrahedron 74: 7303-7309.  (Co-PI)

52.  Eradi, P.; Ghosh, S.; Andreana, P. R.  (2018)  Total Synthesis of Zwitterionic Tetrasaccharide Repeating Unit from Bacteroides fragilis ATCC 25285/NCTC 9343 Capsular Polysaccharide PS A1 with Alternating Charges on Adjacent Monosaccharides.  Organic Letters  20: 4526-4530.  (PI) 

51.  Trabbic, K. R.; Kleski, K. A.; Shi, M.; Bourgault, J.-P.; Prendergast, J. M.; Dransfield, D. T.; Andreana, P. R.  (2018)  Production of a Mouse Monoclonal IgM Antibody that Targets the Carbohydrate Thomsen-nouveau Cancer Antigen Resulting in in vivo and in vitro Tumor Killing.  Cancer Immunology, Immunotherapy  67: 1437-1447.  (PI)

50.  Esmati, N.; Maddirala, A. R.; Hussein, N.; Amawi, H.; Tiwari, A. K.; Andreana, P. R.  (2018)  Efficient Syntheses and Anti-Cancer Activity of Xenortides A-D Including ent/epi-Stereoisomers  Organic & Biomolecular Chemistry  16: 5332-5342.  (PI)

49.  Trabbic, K. R.; Bourgault, J.-P.; Shi, M.; Andreana, P. R.  (2018)  Increasing the Immunogenicity of the TF-Antigen by MGL2 Receptors with Bivalent PS A1 Conjugates.  (In Revision) (PI)

48.  Maddirala, A. R.; Andreana, P. R.  (2018)  Methyl Isocyanide as a Convertible Functional Group for the Synthesis of Spirocyclic Oxindole γ–lactams via Post Ugi-4CR/Transamidation/Cyclization in a One-pot, Three-Step Sequence.  Beilstein Journal of Organic Chemistry 14: 875–883.  (PI)

47.  Patel, K.; Andreana, P. R.  (2017)  "Recent Advances in the Stereochemical Outcome of Multicomponent Reactions Involving Convertable Isocyanides" in Coupling and Decoupling of Diverse Molecular Units in Glycosciences.  Springer International Publishing, pp 67-89.  (PI)

46.  Patel, K.; Song, F.; Andreana, P. R.  (2017)  Synthesis of Substrate Analogues as Potential Inhibitors for Mycobacterium tuberculosis enzyme MshC.  Carbohydrate Research  453–454: 10-18.  (PI)

45.  Jeelani, R.; Jahanbakhsh, S.; Kohan-Ghadr, H.-R.; Thakur, M.; Khan, S.; Aldhaheri, S. R.; Yang, Z.; Andreana, P. R.; Morris, R.; Abu-Souda, H. M.  (2017)  Mesna (2-Mercaptoethane Sodium Sulfonate) Functions as a Regulator of Myeloperoxidase.  Free Radical Biology and Medicine 110: 54–62.  (Co-PI)

44.  Shi, M.; Kleski, K. A.; Trabbic, K. R.; Bourgault, J. P.; Andreana, P. R.  (2016)  STn-PS A1 as an Entirely Carbohydrate Immunogen: Synthesis and Immunological Evaluation.  Journal of the American Chemical Society  138: 14264-14272.  (PI)

43.  Nishat, S.; Andreana, P. R.  (2016)  Entirely Carbohydrate-based Vaccines: An Emerging Field for Specific and Selective Immune Responses.  Vaccines 4: 19.  (PI)  

42.  Ghosh, S.; Nishat, S.; Andreana, P. R.  (2016)  Synthesis of an Aminooxy Derivative of the Tetrasaccharide Repeating Unit of Streptococcus dysgalactiae 2023 Polysaccharide and a PS A1 Conjugate Vaccine.  Journal of Organic Chemistry.  81: 4475-4485.  (PI)

41.  Trabbic, K. R.; Bourgault, J.-P.; Shi, M.; Clark, M.; Andreana, P. R.  (2016) Immunological Evaluation of the Entirely Carbohydrate-based Thomsen-Friedenreich - PS B Conjugate. Organic and Biomolecular Chemistry.  14: 3350-3355. (PI)

40.  Maddirala, A. R.; Andreana, P. R.  (2016)  Synthesis of 3-Substituted-2-Indolinones via a Multicomponent Coupling Isocyanide Dependent Microwave-Assisted Intramolecular Transamidation Process.  European Journal of Organic Chemistry 196-209. (PI)

39.  Santra, S.; Andreana, T. L.; Bourgault, J.-P.; Andreana, P. R. (2015) “Convertible Isocyanides: Application in Small Molecule Synthesis, Carbohydrate Synthesis and Drug Discovery” In Domino and Rearrangement Reactions in Glycoscience Edited by: Z. Witczak and R. Bielski.  John Wiley & Sons Publisher Production Department.  ISBN: 9781119044208. (PI)  

38.  Ghosh, S.; Andreana, P. R.  (2015) Di-t-butylsilyl Bis(trifluoromethanesulfonate). e-EROS Encyclopedia of Reagents for Organic Synthesis March 11, 2015. (PI)

37.  Shaik, A. A.; Nishat, S.; Andreana, P. R.  (2015)  Stereoselective Synthesis of Natural and Non-natural Thomsen-nouveau Antigens and Hydrazide Derivatives.  Organic Letters 17: 2582−2585. (PI)

36.  Bourgault, J. P.; Maddirala, A.; Andreana, P. R.  (2014)  A One-Pot Multicomponent Coupling/Cyclization for Natural Product Herbicide (±)-Thaxtomin A.  Organic and Biomolecular Chemistry 12: 8125-8127. (PI)  Journal Cover.

35.  Ghosh, S.; Andreana, P. R.  (2014)  Synthesis of an Aminooxy Derivative of the Trisaccharide Globotriose Gb3.  Journal of Carbohydrate Chemistry 33: 381-394. (PI)

34.  Trabbic, K. R.; De Silva, R. A; Andreana, P. R.  (2014)  Elucidating Structural Features of an Entirely Carbohydrate Cancer Vaccine Construct Employing Circular Dichroism and Fluorescent Labeling.  Medicinal Chemistry Communication 5: 1143-1149 (PI)

33.  Bourgault, J. P.; Trabbic, K. R.; Shi, M.; Andreana, P. R.  (2014)  Synthesis of the Tumor Associative α-Aminooxy Disaccharide of the TF Antigen and its Conjugation to a Polysaccharide Immune Stimulant.  Organic and Biomolecular Chemistry 12: 1699-1702. (PI)  Journal Cover.

32.  Abu-Soud, H. M.; Maitra, D.; Shaeib, F.; Byun, J.; Abdulhamid, I.; Saed, G. M.; Diamond, M. P.; Andreana, P. R.; Pennathur, S.  (2014)  Disruption of Heme-Peptide Covalent Cross-Linking in Mammalian Peroxidases by Hypochlorous Acid  Journal of Inorganic Biochemistry 140: 245-254. (Co-PI)

31.  De Silva, R. A.; Appulage, D. K.; Pietraszkiewicz, H.; Bobbitt, K. R.; Media, J.; Shaw, J.; Valeriote, F. A.; Andreana, P. R.  (2012)  The Entirely Carbohydrate Immunogen Tn-PS A1 Induces a Cancer Cell Selective Immune Response and Cytokine IL-17.  Cancer Immunology, Immunotherapy 61: 581-585. (PI)

30.  Shaw, J.; Chen, B.; Bourgault, J. P.; Jiang, H.; Kumar, N.; Mishra, J.; Valeriote, F. A.; Media, J.; Bobbitt, K.; Pietraszkiewicz, H.; Edelstein, M.; Andreana, P. R.  (2012)  Synthesis and Biological Evaluation of Novel N-phenyl-5-carboxamidyl Isoxazoles as Potential Chemotherapeutic Agents for Colon Cancer.  American Journal of Biomedical Sciences 4: 14-25. (Co-PI)

29.  Abu-Soud, H. M.; Maitra, D.; Byun, J.; Souza, C. E. A.; Banerjee, J.; Andreana, P. R.; Pennathur, S. (2012)  The Reaction of HOCl and Cyanocobalamin: Corrin Destruction and the Liberation of Cyanogen Chloride.  Free Radical Biology and Medicine 52: 616-625. (Co-PI)

28.  Santra, S.; Andreana, P. R.  (2011)  A Bioinspired Ugi/Michael/aza-Michael Cascade Reaction in Aqueous Media: Natural Product-Like Molecular Diversity.  Angewandte Chemie International Edition 50: 9418-9422. (PI) Designated as Hot Paper.

27.  Maitra, D.; Byun, J.; Andreana, P. R.; Abdulhamid, I.; Diamond, M. P.; Saed, G. M.; Pennathur, S.; Abu-Soud, S. M.  (2011) Reaction of Hemoglobin with HOCl: Mechanism of Heme Destruction and Free Iron Release.  Free Radical Biology and Medicine  51: 374-386. (Co-PI)

26.  Maitra, D.; Byun, J.; Andreana, P. R.; Abdulhamid, I.; Saed, G. M.; Diamond, M. P.; Pennathur, S.; Abu-Soud, S. M.  (2011)  Mechanism of Hypochlorous Acid-Mediated Heme Destruction and Free Iron Release.  Free Radical Biology and Medicine  51: 364-373. (Co-PI)

25.  Santra, S.; Jonas, E.; Bourgault J.-P.; El-Baba, T; Andreana, P. R.  (2011) Kinetic Products Under Thermal Conditions: Rapid Entry into Anomeric Substituted a/b-D-Galactofuranosides Using Microwave Irradiation and Selective Lewis Acids.  Journal of Carbohydrate Chemistry  30: 27-40. (PI)

24.  Santra, S.; Andreana, P. R.  (2011) A Rapid, One-Pot, Microwave-Influenced Synthesis of Spiro-2,5-Diketopiperazines via a Cascade Ugi/6-exo-trig aza-Michael Reaction.  Journal of Organic Chemistry 76: 2261-2264. (PI)

23.  De Silva, R. A.; Wang, Q.; Chidley, T.; Appulage, D. K.; Andreana, P. R. (2009)  Immunological Response from an Entirely Carbohydrate Antigen: Design of Synthetic Vaccines Based on Tn-PS A1 Conjugates.  Journal of the American Chemical Society  131: 9622-9623. (PI)

22.  Yatawara, A. K.; Tiruchinapally, G.; Bordenyuk, A. N.; Andreana, P. R.; Benderskii, A. V.  (2009) Carbohydrate Surface Attachment Characterized by Sum Frequency Generation Spectroscopy. Langmuir  25: 1901-1904. (Co-PI)

21.  De Silva, R. A.; Santra, S.; Andreana, P. R.  (2008) A Tandem One-Pot, Microwave-Assisted Synthesis of Regiochemically Differentiated 1,2,4,5-Tetrahydro-1,4-benzodiazepin-3-ones. Organic Letters  10: 4541-4544. (PI) Highlighted In: Organic Chemistry Portal (Org. Chem. Highlights) October 15, 2008.

20.  Santra, S.; Andreana, P. R.  (2007) A One-Pot, Microwave-Influenced Synthesis of Diverse Small Molecules by Multicomponent Reaction Cascades. Organic Letters 9: 5035-5038. (PI)  Highlighted In: Organic Chemistry Portal (Org. Chem. Highlights) November 15, 2007.

19.  Andreana, P. R.; Liu, C. C.; Schreiber, S. L. (2004)  Stereochemical Control of the Passerini Reaction.  Organic Letters 6: 4231-4233. (Post-doc work)

18.  Andreana, P. R.; Kowal, P.; Janczuk, A. J.; Wang, P. G. (2004)  Alpha-Galactosyl Trisaccharide Epitope: Modification of the 6-Primary Positions and Recognition by Human Anti-a-Gal Antibody. Glycoconjugate Journal 20 (2): 107-118. (Ph.D. work)

17.  Sello, J. K.; Andreana, P. R.; Lee, D.; Schreiber, S. L. (2003)  Stereochemical Control of Skeletal Diversity. Organic Letters 5: 4125-4127. (Post-doc work)

16.  Postema, M. H. D.; Piper, J. L.; Liu, L.; Shen, J.; Faust, M.; Andreana, P. (2003)  Synthesis and Partial Biological Evaluation of a Small Library of Differentially-Linked -C-Disaccharides. Journal of Organic Chemistry 68: 4748-4754. (Ph.D. work)

15.  Andreana, P. R.; McLellan, J. S.; Chen, Y.; Wang, P. G. (2002)  Synthesis of 2,6-Dideoxysugars via Ring Closing Olefinic Metathesis. Organic Letters 4: 3875-3878. (Ph.D. work)  Hot Article Oct./02.  Cited in C&EN News Dec. 23/02.

14.  Andreana, P. R.; Sanders, T.; Janczuk, A.; Warrick, J. I.; Wang, P. G. (2002)  Chemo-Enzymatic Synthesis of Polyhydroxyazepanes. Tetrahedron Letters 43: 6525-6528. (Ph.D. work)

13.  Janczuk, A. J.; Zhang, W.; Andreana, P. R.; Warrick, J.; Wang P. G. (2002)  The Synthesis of Deoxy a-Gal Epitope Derivatives for the Evaluation of Anti-a-Gal Antibody Binding. Carbohydrate Research 337: 1247-1259. (Ph.D. work)

12.  Andreana, P. R.; Xie, W.; Cheng, H. N.; Qiao, L.; Murphy, D. J.; Gu, Q. M.; Wang, P. G. (2002)  In-Situ Preparation of b-D-1-O-Hydroxylamino Carbohydrate Polymers Mediated by Galactose Oxidase.  Organic Letters 4: 1863-1866. (Ph.D. work)

11.  Zhang, J.; Kowal, P.; Fang, J.; Andreana, P.; Wang, P. G. (2002)  Efficient Chemoenzymatic Synthesis of Globotriose and Its Derivatives with a Recombinant alpha-(1-4)-Galactosyltransferase.  Carbohydrate Research 337: 969-976. (Ph.D. work)

10.  Chen, X.; Zhang, J.; Kowal, P.; Liu, Z.; Andreana, P. R.; Lu, Y.; Wang, P. G. (2001)  Transferring a Biosynthetic Cycle into a Productive Escherichia coli Strain: Large-Scale Synthesis of Galactosides.  Journal of the American Chemical Society 123:  8866-8867. (Ph.D. work)

9.  Chen, X.; Fang, J.; Zhang, J.; Andreana, P. R.; Shao, J.; Kowal, P.; Wang, P. G. (2001)  Sugar Nucleotide Regeneration Beads (Superbeads): A Versatile Tool for Practical Synthesis of Oligosaccharides.  Journal of the American Chemical Society 123:  2081-2082.  (Ph.D. work)

8.  Holland, H. L.; Andreana, P. R.; Salehzadeh-Asl, R.; van Vliet, A.; Ihasz, N. J.; Brown, F. M. (2000) Beauveria bassiana ATCC 7159 Contains an L-Specific alpha-Amino Acid Benzamidase.  Monatshefte fur Chemie 131: (6) 667-672. (Hons B.Sc. work)

7.  Hou, Y. -C.; Chen, Y. -S.; Amro, N. A.; Wadu-Mesthrige, K.; Andreana, P. R.; Wang, P. G. (2000)  Nano-Molar Scale Nitric Oxide Generation From Self-Assembled Monolayer Modified Gold Electrodes.  Chemical Communication  19: 1831-1832. (Ph.D. work) Editor’s Choice in Science, Oct. 13/00.

6.  Fang, J. W.; Chen, X.; Zhang, W.; Wang, J. Q.; Andreana, P. R.; Wang, P. G. (1999)  A Unique Chemoenzymatic Synthesis of alpha-Galactosyl Epitope Derivatives Containing Free Amino Groups: Efficient Separation and Further Manipulation.  Journal of Organic Chemistry 64: (11) 4089-4094. (Ph.D. work)

5.  Chen, X.; Andreana, P. R.; Wang, P. G. (1999)  Carbohydrates in Transplantation. Current Opinion in Chemical Biology 3:650-658.(Ph.D. work)

4.  Hou, Y.-C.; Wang, J.-Q.; Andreana, P. R.; Cantauria, G.; Tarasia, S.; Sharp, L.; Braunschweiger, P. G.; Wang, P. G. (1999)  Targeting Nitric Oxide to Cancer Cells: Cytotoxicity Studies of Glyco-S Nitrosothiols.  Bioorganic andMedicinal Chemistry Letters 9: 2255-2258. (Ph.D. work)

3.  Holland, H. L.; Turner, C. D.; Andreana, P. R.; Nguyen, D. (1999)  Biotransformation of Organic Sulfides. Part 12. Conversion of Heterocyclic Sulfides to Chiral Sulfoxides by Helminthosporiumsp NRRL 4671 and Mortierella isabellina ATCC 42613.  Canadian Journal of Chemistry Revue Canadienne de Chimie 77: (4) 463-471. (Hons. B.Sc. work)

2.  Holland, H. L.; Andreana, P. R.; Brown, F. M. (1999)  Biocatalytic and Chemical Routes to all the Stereoisomers of Methionine and Ethionine Sulfoxides. Tetrahedron: Asymmetry 10: (15) 2833-2843. (Hons B.Sc. work)

1.  Holland, H. L.; Kohl, A.; Larsen, B. G.; Andreana, P.; Gu, J. X. (1997)  Preparation of Substituted (R)-2-Alkanols by Microbial Hydroxylation.  Journal of Molecular Catalysis B-Enzymatic. 2: (6) L253-L255. (Hons B.Sc. work)

Last Updated: 11/26/19