AMIT K. TIWARI, Ph.D.
Associate Professor of Pharmacology, College of Pharmacy & Pharmaceutical Sciences
Associate Professor of Cell and Cancer Biology, College of Medicine & Life Sciences
Director of International Engagement
amit.tiwari@utoledo.edu
EDUCATION:
| B.S. | 2005 | Pharmacy | RamEesh Institute, U.P.T.U. University, India |
| M.S. | 2008 | Pharmaceutical Sciences and Pharmacology | St. John's University, New York |
| Ph.D. | 2011 | Pharmaceutical Sciences and Pharmacology | St. John's University, New York |
| Post-Doc | 2013 | Pharmacology | Mount Sinai School of Medicine, New York |
RESEARCH INTERESTS:
Dr. Tiwari directs the Cancer and Systems Therapeutics (CAST) program at the University
of Toledo and holds a joint position in the College of Pharmacy & Pharmaceutical Sciences
and College of Medicine & Life Sciences. CAST team is involved in a) developing effective,
safe, and targeted anticancer molecules against multidrug-resistant cancers; b) designing,
synthesizing and characterizing non-conventional forms of cell death inducers i.e.,
modulators of necroptosis, methuosis, and autophagy. CAST is also engaged in innovative
drug delivery systems, natural products drug discovery, and chemical toxicity. CASTers
are particularly interested in the identification of novel targets (single and multi-targets),
synthesis and optimization of lead compounds, PK (ADME), PD (i.e., efficacy, model/assay
developments, and mechanistic studies), drug-drug/herbal interactions, drug resistance,
advanced toxicology assessments, and IP protection and commercialization.
FUNDING:
Ongoing Research Support
1W81XWH-21-1-0053 (BC200858), Department of Defense, Level II
Development of Novel Inducers of Nonapoptotic Cell Death to Target TNBC
1/1/2021-12/31/2023
Role: PI
CCR18548498, Susan G. Komen CCR Award
Necroptosis induction to target triple negative breast cancer
8/7/2018-8/6/2022
Role: PI
ODHE HABRI FY20/21, Ohio State Dept. of Higher Education (ODHE)
Health Effects of Dermal Contact to Cyanotoxins in At-Risk Pre-existing Disease States
11/1/21 – 10/30/23
Role: co-I; PI: Kennedy, D.
A 1919337, National Science Foundation
MRI: Acquisition of a Transmission Electron Microscope for Research and Training
8/1/2019-7/30/2022
Role: co-PI; PI: Gunning, W.
Completed Research Support
RA, Systems Oncology-sponsored research agreement
Development of Patentable, Methuophagy Inducing Compounds for Cancer Therapy
8/1/2018-10/30/2019
Role: PI
Foundation, The Paso Del Norte Health Foundation
In vivo Characterization of Nicotine Loaded Solid Lipid Nanoparticle Hydrogels
3/1/2018-8/30/2019
Role: co-I; Boddu SH, PI
Pilot grant, Woods Hole Pilot Grant
Alkenones Toxicity and Applications
11/1/2017-3/30/2019
Role: PI
Competitive grant, California Grape Commission
Effects of Whole Grape Powder on NF-kB Driven Inflammatory Signaling
08/1/2014-7/30/2015
Role: co-PI; Samuel T, PI
Pilot-U54, National Institute of Health
The Role of TTP-Lin28-let-7-axis in the Regulation of Colorectal Cancer Treatment
03/1/2014-2/27/2015
Role: PI; Esther S, Co-PI; Program PI – Manne, U
PUBLICATIONS:
STUDENT OPENINGS: Currently accepting Ph.D., M.D./Ph.D., M.S.B.S., and M.S. students