Department of Chemistry and Biochemistry

Dr. Mueser's Publications

1.) Mueser, T., Isaac, L., and Radulovacki, M., Neither REM Sleep Deprivation nor Rebound Influences 3H‑Diazepam binding in Rat Brain, Physiology and Behavior, 31, 257‑239, Pergamon Press LTD, (1983). [1]

 2.) Dholakia, J., Mueser, T., Woodley, C., Parkhurst, L.J., and Wahba, A.J., The Association of NADPH with the Guanine Nucleotide Exchange Factor from Rabbit Reticulocytes. A Role of Pyridine Nucleotides in Polypeptide Chain Initiation, Proc. Nat. Acad. Sci., 83, 6746‑6750 (1986). [2]

 3.) Parkhurst, L.J., T.M. Larsen , and T.C. Mueser., Quantitation of the Binding of Oxygen to Human Hemoglobin.  Biophys. J. 57: (2) A231-A231 Part 2 Feb 1990. [3]

 4.) Larsen, T.M., T.C. Mueser, and L.J. Parkhurst., Use of Dual Wavelength Spectrophotometry and Continuous Enzymatic Depletion of Oxygen for Determination of the Oxygen Binding Constants of Hemoglobin. Anal. Biochem. 197, 231‑246 (1991). [4]

 5.) Mueser, T.C., and Parkhurst, L.J., Synthesis of DANSYL Ribonucleotides and Their Use in Steady‑State Fluorescence Anisotropy Studies of Nucleotide Binding by Initiation Factor‑2 (eIF‑2) and Histone H1. Int. J. Biochem, Vol. 25, No. 11, pp. 1689‑1696, 1993. [5]

 6.) Timothy C. Mueser, Nancy G. Nossal, and C. Craig Hyde. Structure of Bacteriophage T4 RNase H, a 5’ to 3’ Exonuclease with Sequence Similarity to the RAD2 Family of Eukaryotic Repair and Replication Proteins. Cell, Vol. 85, pp. 1101‑1112, 1996. [6]

 7.) Vora, A.C., Chiu, R., McCord, M., Goodarzi, G., Stahl, S.J., Mueser, T.C.,Hyde, C.C., and Grandgenett, D.P. Avian retrovirus U3 and U5 DNA inverted repeats: Role of Nonsymmetrical Nucleotides in Promoting Full‑site Integration by Purified Virion and Bacterial Recombinant Integrases. J. Biol. Chem., Vol. 272, No. 38, pp 23938-23945, 1997. [7]

 8.) McCord, M., Stahl, S.J., Mueser, T.C., Hyde, C.C., Vora, A.C, and Grandgenett, D.P. Purification of recombinant Rous sarcoma virus integrase possessing physical and catalytic properties similar to virion-derived integrase.  Protein Expression and Purification, 14, pp. 167-177, 1998. [8]

 9.) Zhong-ning Yang, Timothy C. Mueser, Joshua Kaufman, Stephen Stahl, Paul T. Wingfield, and C. Craig Hyde. The Crystal Structure of the SIV gp41 Ectodomain at 1.47 Å Resolution. J. Struct. Bio. 1999. 126 (2), 131-144. [9]

 10.) Timothy C. Mueser, Charles E. Jones, Nancy G. Nossal, and C. Craig Hyde.  Bacteriophage T4 Gene 59 Helicase Assembly Protein binds replication fork DNA.  The 1.45 Å resolution crystal structure reveals a novel a‑helical two‑domain fold. J. Mol. Bio. (2000) 296 (2), 597-612. [10]

 11.) Zhong-ning Yang*, Timothy C. Mueser*, Frederick Bushman, and C. Craig Hyde. Crystal Structure of an Active Two-domain Derivative of Rous Sarcoma Virus Integrase.  *Co-first author contribution.  J. Mol. Bio. (2000) 296 (2), 535-548. [11]

 12.) Charles E. Jones, Timothy C. Mueser, and Nancy G. Nossal. Interaction of the Bacteriophage T4 Gene 59 Helicase Loading Protein and Gene 41 Helicase with Each Other, and with Fork, Flap, and Cruciform DNA. J. Biol. Chem. (2000) 275, 27145-27154. [12]

 13.) Mueser, T. C., Rogers, P. H., and Arnone, A.  Interface Sliding as Illustrated by the Multiple Quaternary Structures of Liganded Hemoglobin. Biochem. (2000)39, 15353-15364. [13]

 14.) Charles E. Jones, Timothy C. Mueser, Kathleen C. Dudas, Kenneth N. Kreuzer, and Nancy G. Nossal. Bacteriophage T4 Gene 41 Helicase and Gene 59 Helicase Loading Protein: a Versatile Couple with Roles in Replication and Recombination.  Proc. Nat. Acad. Sci. Colloquium (2001) 98 (15), 8312-8318. [14]

 15.) Charles E. Jones, Erin Green, Julia Stephens, Timothy C. Mueser, and Nancy G. Nossal Mutations of Bacteriophage T4 59 Helicase Loader Defective in Fork Binding and Interactions with T4 32 Single-Stranded DNA Binding Protein. J. Biol. Chem. (2004) 279, 25721-8. [15]

 16.) Charles E. Jones, Timothy C. Mueser, and Nancy G. Nossal.  Bacteriophage T4 32 Protein is Required for Helicase-dependent Leading Strand Synthesis when the Helicase is Loaded by the T4 59 Helicase-Loading Protein.  J. Biol. Chem. (2004) 279, 12067-75. [16]

 17.) Sung Gyun Kang, Michael R. Maurizi, Mark Thompson, Timothy Mueser and Bijan Ahvazi. Crystallography and Mutagenesis Point to an Essential Role for the N-terminus of Human Mitochondrial ClpP. J. Struct. Bio. (2004), Volume 148, Issue 3, Pages 338-352. [17]

 18.) Brandon K. Collins, Stephen J. Tomanicek, Natasha Lyamicheva, Michael W. Kaiser and Timothy C. Mueser.  A Preliminary Solubility Screen used to Improve Crystallization Trials: Crystallization and Preliminary X-ray Structure Determination of Aeropyrum pernix Flap Endonuclease-1, Acta Crystallogr D Biol Crystallogr. (2004) 60(Pt 9),1674-8. [18]

 19.) Anne B. Senger and Timothy C. Mueser.  Rapid Preparation of Custom Grid Screens for Protein Crystal Growth Optimization. J. Appl. Cryst. (2005). 38, 847-850. [19]

 20.) Aude Izaac, Constance Schall and Timothy C. Mueser.  Assessment of a Preliminary Solubility Screen to Improve Crystallization Trials: Uncoupling Crystal Condition Searches.  Acta Crystallographica Section D Biological Crystallography (2006), D62, 833-842. [20]

 21.) Boeshans, K.M., Wolf, R., Voscopoulob, C., Gillette, W., Espoosito, D., Yuspa, S., H.,
Mueser, T.C., and Ahvazi, B. (2006) Purification, Crystallization and Preliminary X-ray
Diffraction of Human S100A15.
Acta Crystallographica Section F, May 1;62(Pt 5):467-70. [21]

 22.) Boeshans, K.M., Mueser, T.C., and Ahvazi, B. (2007) A three-dimensional model of the human transglutaminase 1: insights into the understanding of lamellar ichthyosis. J Mol Model. Jan;13(1):233-46. [22]

 23.) Nossal NG, Jones CE, Makhov A, Chastain P, Griffith J, Devos JM, Mueser TC. Architecture and function of the phage T4 replication fork. FASEB Journal 20 (4): A420-A420 Part 1, Mar 6, 2006, Meeting Abstract. [23]

 24.) Devos, J.M., Tomanicek, S.J., Jones, C.E., Nossal, N.G., and Mueser, T.C. (2007). Crystal structure of bacteriophage T4 5' nuclease in complex with a branched DNA reveals how flap endonuclease-1 family nucleases bind their substrates. J Biol Chem 282, 31713-31724. [24]

 25.) Gosavi, R.A., Mueser, T.C., and Schall, C.A. (2008). Optimization of buffer solutions for protein crystallization. Acta Crystallogr D Biol Crystallogr 64, 506-514. [25]

 26.) Kovalevsky AY, Fisher SZ, Seaver S, Mustyakimov M, Sukumar N, Langan P, Mueser TC, Hanson BL. Preliminary neutron and X-ray crystallographic studies of equine cyanomethemoglobin. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Apr 1;66(Pt 4):474-7. [26]

 27.) Timothy C. Mueser, Jennifer M. Hinerman, Juliette M. Devos, Ryan A. Boyer and Kandace J. Williams. Structural analysis of bacteriophage T4 DNA replication: a review in the Virology Journal series on bacteriophage T4 and its relatives. Virology Journal, (2010) 7, 359. [27]

 28.) Timothy C. Mueser and Kandace J. Williams   Alkylation chemotherapy: Mechanistic potential and pitfalls. Novus invited book chapter: “Mutations: Types, Harmful Mutations and Beneficial Mutations” Advances in Genetics Research. (2011) Volume 4; ISBN 978-1-61728-764-0. [28]

 29.) Timothy C. Mueser, Wendell Griffith, Andrey Y. Kovalevsky, Jingshu Guo, Sean Seaver, Paul Langan, and B. Leif Hanson.  Hemoglobin Redux: Combining Neutron and X-ray Diffraction, with Mass Spectrometry to Analyse the Quaternary State of Oxidized Hemoglobins. Acta Crystallogr D Biol Crystallogr. 2010 Nov; 66(Pt 11):1249-56. [29]

 30.) Dignam, J. D., Guo, J., Griffith, W. P., Garbett, N. C., Holloway, A., and Mueser, T. (2011) Allosteric interaction of nucleotides and tRNA(ala) with E. coli alanyl-tRNA synthetase, Biochemistry 50, 9886-9900. [30]

 31.) Xu, S., Mueser, T. C., Marnett, L. J., and Funk, M. O., Jr. (2012) Crystal Structure of 12-Lipoxygenase Catalytic-Domain-Inhibitor Complex Identifies a Substrate-Binding Channel for Catalysis, Structure. Structure, 2012 Sep 5;20(9):1490-7. [31]

 32.) Hinerman, J. M., Dignam, J. D., and Mueser, T. C. (2012) Models for the binary complex of bacteriophage T4 gp59 helicase loading protein: gp32 single-stranded DNA-BINDING protein and ternary complex with pseudo-Y junction DNA, The Journal of Biological Chemistry 287, 18608-18617. [32]

 33.) Dolezal, D., Jones, C. E., Lai, X., Brister, J. R., Mueser, T. C., Nossal, N. G., and Hinton, D. M. (2012) Mutational analysis of the T4 Gp59 helicase loader reveals its sites for interaction with helicase, single stranded binding protein, and DNA, The Journal of Biological Chemistry. 287(22):18608-17. [33]

 34.) Guo, J. S., Uppal, S., Easthon, L. M., Mueser, T. C., and Griffith, W. P. (2012) Complete sequence determination of hemoglobin from endangered feline species using a combined ESI-MS and X-ray crystallography approach, Int J Mass Spectrom 312, 70-77. [34]

 35.) Amato, N. J., Mwai, C. N., Mueser, T. C., and Bryant-Friedrich, A. C. (2013) Thermodynamic and structural analysis of DNA damage architectures related to replication, Journal of Nucleic Acids 2013, 867957. [35]

 36.) Steven Dajnowicz, Sean Seaver, B. Leif Hanson, S. Zoë Fisher, Paul Langan, Andrey Y. Kovalevsky, Timothy C. Mueser. Visualizing the Bohr Effect in Hemoglobin: Neutron Structure of Equine Cyanomethemoglobin in the R-state and Comparison with Human Deoxyhemoglobin in the T-state. Acta Crystallogr D Struct Biol. 2016 Jul 1;72(Pt 7):892-903. [36]

 37.) Steven Dajnowicz, Jerry M. Parks, Xiche Hu, Korie Gesler, Andrey Y. Kovalevsky, Timothy C. Mueser. Extended Hydrogen Bonding Network Influences Activation of Pyridoxal 5’-Phosphate in Aspartate Aminotransferase. J Biol Chem. 2017 Apr 7;292(14):5970-5980. doi: 10.1074/jbc.M116.774588. Epub 2017 Feb 23. [37]

 38.) Steven Dajnowicz, Ryne C. Johnston, Jerry M. Parks, Matthew P. Blakeley, David A. Keen, Kevin L. Weiss, Oksana Gerlits, Andrey Kovalevsky*, Timothy C. Mueser*. Direct visualization of critical hydrogen atoms in a pyridoxal 5’-phosphate enzyme. Nature Communications, In Press, Aug 2017. [38]

Last Updated: 6/30/19